PGH2_HUMAN - dbPTM
PGH2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PGH2_HUMAN
UniProt AC P35354
Protein Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Organism Homo sapiens (Human).
Sequence Length 604
Subcellular Localization Microsome membrane
Peripheral membrane protein. Endoplasmic reticulum membrane
Peripheral membrane protein.
Protein Description Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. [PubMed: 26859324]
Protein Sequence MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationMSVGFDQYKCDCTRT
EEECCCEEEECCCCE		18.5430576142
53N-linked_GlycosylationRTGFYGENCSTPEFL
CEECCCCCCCCHHHH		22.2226859324
55PhosphorylationGFYGENCSTPEFLTR
ECCCCCCCCHHHHHH		59.5930576142
56PhosphorylationFYGENCSTPEFLTRI
CCCCCCCCHHHHHHE		29.1030576142
100PhosphorylationFLRNAIMSYVLTSRS
HHHHHHHHHHHHCCH		13.1328111955
101PhosphorylationLRNAIMSYVLTSRSH
HHHHHHHHHHHCCHH		5.1028111955
104PhosphorylationAIMSYVLTSRSHLID
HHHHHHHHCCHHCCC		16.4328111955
105PhosphorylationIMSYVLTSRSHLIDS
HHHHHHHCCHHCCCC		27.8528111955
107PhosphorylationSYVLTSRSHLIDSPP
HHHHHCCHHCCCCCC		23.5528111955
112PhosphorylationSRSHLIDSPPTYNAD
CCHHCCCCCCCCCCC		26.2828111955
115PhosphorylationHLIDSPPTYNADYGY
HCCCCCCCCCCCCCC		32.5628111955
116PhosphorylationLIDSPPTYNADYGYK
CCCCCCCCCCCCCCC		17.7128111955
120PhosphorylationPPTYNADYGYKSWEA
CCCCCCCCCCCCHHH		21.6828111955
122PhosphorylationTYNADYGYKSWEAFS
CCCCCCCCCCHHHHH		8.8128111955
130N-linked_GlycosylationKSWEAFSNLSYYTRA
CCHHHHHCCCHHHCC		26.9326859324
152UbiquitinationCPTPLGVKGKKQLPD
CCCCCCCCCCCCCCC		64.3133845483
155UbiquitinationPLGVKGKKQLPDSNE
CCCCCCCCCCCCHHH		66.7829967540
166UbiquitinationDSNEIVEKLLLRRKF
CHHHHHHHHHHHCCC		33.2829967540
2392-HydroxyisobutyrylationLFKDGKMKYQIIDGE
EEECCCCEEEEECCC		37.17-
240PhosphorylationFKDGKMKYQIIDGEM
EECCCCEEEEECCCC		11.0522210691
248PhosphorylationQIIDGEMYPPTVKDT
EEECCCCCCCCCCCC		11.1922210691
251PhosphorylationDGEMYPPTVKDTQAE
CCCCCCCCCCCCCEE		35.3722210691
346UbiquitinationSGYHFKLKFDPELLF
CCCCEEECCCHHHHC		48.5929967540
371NitrationAAEFNTLYHWHPLLP
HHHHHHHHCCCCCCC		10.79-
396N-linked_GlycosylationNYQQFIYNNSILLEH
CCHHHEECCHHHHHC		30.8426859324
434PhosphorylationPPAVQKVSQASIDQS
CHHHHHHHHHHCHHH		27.3721964256
437PhosphorylationVQKVSQASIDQSRQM
HHHHHHHHCHHHHHH		21.0421964256
445UbiquitinationIDQSRQMKYQSFNEY
CHHHHHHHHHCHHHH		31.6229967540
446PhosphorylationDQSRQMKYQSFNEYR
HHHHHHHHHCHHHHH		12.2122817900
526S-nitrosocysteineGLMGNVICSPAYWKP
HHCCCEEEECCCCCC		3.29-
526S-nitrosylationGLMGNVICSPAYWKP
HHCCCEEEECCCCCC		3.2916373578
565AcetylationVKGCPFTSFSVPDPE
CCCCCCCCCCCCCHH		18.86-
580N-linked_GlycosylationLIKTVTINASSSRSG
HEEEEEEECCCCCCC		25.1417113084
598UbiquitinationINPTVLLKERSTEL-
CCCCEEEECCCCCC-		47.0933845483
601PhosphorylationTVLLKERSTEL----
CEEEECCCCCC----		27.59-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
120YPhosphorylationKinaseLYNP07948
PSP
446YPhosphorylationKinaseFYNP06241
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
526CS-nitrosylation

16373578
565SAcetylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PGH2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAV1_HUMANCAV1physical
11432874
CSN5_HUMANCOPS5physical
17429597
CSN3_HUMANCOPS3physical
17429597
CUL1_HUMANCUL1physical
17429597
CUL4A_HUMANCUL4Aphysical
17429597
RBX1_HUMANRBX1physical
17429597
PSMD1_HUMANPSMD1physical
17429597
PRS8_HUMANPSMC5physical
17429597
NOS2_MOUSENos2physical
16373578
PTGIS_HUMANPTGISphysical
21035466
PGH2_HUMANPTGS2physical
23955344
PGH2_HUMANPTGS2physical
16606823
DERL1_HUMANDERL1physical
24089527
SELS_HUMANVIMPphysical
24089527
TERA_HUMANVCPphysical
24089527
CAV1_HUMANCAV1physical
24089527
P53_HUMANTP53physical
19465063
ELMO1_HUMANELMO1physical
20732417
PGH1_HUMANPTGS1physical
18838483
NUCB1_HUMANNUCB1physical
18493301
P53_HUMANTP53physical
16928824
EP300_HUMANEP300physical
16928824
PGH2_HUMANPTGS2physical
21467029
P53_HUMANTP53physical
21187340
EP300_HUMANEP300physical
21187340
CSKP_HUMANCASKphysical
24722188
UBP22_HUMANUSP22physical
25817787
A4_HUMANAPPphysical
14724276
P53_HUMANTP53physical
15707991
PGH2_HUMANPTGS2physical
27226593
AGTR1_HUMANAGTR1physical
25231994
PE2R1_HUMANPTGER1physical
24614038
Drug and Disease Associations
Kegg Disease
H00017 Esophageal cancer
H00025 Penile cancer
H00046 Cholangiocarcinoma
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00109 Aspirin (JP16/USP); Aspalon (JAN); Acetylsalicylic acid; Easprin (TN)
D00118 Naproxen (JP16/USP/INN); Naprosyn (TN)
D00120 Sulindac (JP16/USP/INN); Clinoril (TN)
D00126 Ibuprofen (JP16/USP/INN); Advil (TN); Motrin (TN)
D00127 Piroxicam (JP16/USP/INN); Feldene (TN)
D00130 Diflunisal (JAN/USP/INN); Dolobid (TN)
D00132 Ketoprofen (JP16/USP/INN); Orudis (TN)
D00141 Indometacin (JP16/INN); Indomethacin (USP); Aconip (TN); Indocin (TN)
D00151 Mefenamic acid (JP16/USP/INN); Ponstel (TN)
D00158 Tolmetin sodium (JAN/USP); Tolmetin sodium dihydrate; Tolectin (TN)
D00169 Meclofenamate sodium (USP); Meclofenamate sodium monohydrate; Meclomen (TN)
D00315 Etodolac (JP16/USP/INN); Lodine (TN)
D00330 Flurbiprofen (JP16/USP/INN); Ansaid (TN)
D00425 Nabumetone (JP16/USP/INN); Relafen (TN)
D00428 Sasapyrine (JAN); Salsalate (USP/INN); Disalcid (TN)
D00463 Oxaprozin (JP16/USAN/INN); Daypro (TN)
D00510 Phenylbutazone (JP16/USP/INN); Azolid (TN)
D00566 Sodium salicylate (JP16/USP); Salsonin (TN)
D00567 Celecoxib (JAN/USAN/INN); Celebrex (TN)
D00568 Rofecoxib (JAN/USAN/INN); Vioxx (TN)
D00810 Choline salicylate (JAN/USAN/INN); Arthropan (TN)
D00813 Ketorolac tromethamine (USP); Acular (TN); Toradol (TN)
D00827 Magnesium salicylate (USP); Magnesium salicylate tetrahydrate; Magan (TN)
D00903 Diclofenac potassium (USAN); Cambia (TN); Cataflam (TN); Zipsor (TN)
D00904 Diclofenac sodium (JP16/USP); Solaraze (TN); Voltaren (TN)
D00968 Fenoprofen calcium (JAN/USP); Nalfon (TN)
D00969 Meloxicam (JAN/USAN/INN); Mobic (TN)
D00970 Naproxen sodium (USP); Anaprox (TN)
D01049 Nimesulide (JAN/INN)
D01122 Ibuprofen piconol (JP16/USAN); Staderm (TN)
D01183 Tolfenamic acid (JAN/INN); Clotam (TN)
D01267 Floctafenine (JAN/USAN/INN); Idarac (TN)
D01325 Tiaprofenic acid (JAN/INN); Surgam (TN)
D01397 Ampiroxicam (JAN/INN); Flucam (TN)
D01410 Benzydamine hydrochloride (JAN/USAN); Tantum (TN)
D01475 Flurbiprofen axetil (JAN); FP 83; Ropion (TN)
D01513 Alminoprofen (JP16/INN); Minalfen (TN)
D01545 Aceclofenac (JAN/INN); Aceclofenac (TN)
D01547 Zaltoprofen (JP16/INN); CN 100; Peon (TN)
D01565 Indometacin farnesil (JAN); Infree (TN)
D01578 Pranoprofen (JP16/INN); Elicapric (TN)
D01581 Flufenamic acid (JAN/USAN/INN); Arlef (TN)
D01582 Acemetacin (JP16/INN); Rantudil (TN)
D01675 Felbinac (JP16/USAN/INN); Dolinac (TN); Felbinac (TN)
D01709 Loxoprofen sodium hydrate (JP16); Lorfenamin (TN); Loxonin (TN)
D01765 Proglumetacin maleate (JAN); Miridacin (TN)
D01767 Tenoxicam (JAN/USAN/INN); Tilcotil (TN)
D01788 Amfenac sodium hydrate (JAN); Amfenac sodium (USAN); Fenazox (TN)
D01811 Salicylamide (JAN/USP/INN); Salicylamide (TN)
D01841 Felbinac ethyl (JAN); LM 001
D01866 Lornoxicam (JAN/USAN/INN); Lorcam (TN)
D01974 Tilmacoxib (JAN/USAN/INN)
D02110 Indometacin sodium (JAN); Indomethacin sodium (USP); Indomethacin sodium trihydrate; Indocin I.V. (T
D02290 Flurbiprofen sodium (USP); Ocufen (TN)
D02341 Meclofenamic acid (USAN/INN)
D02350 Fenoprofen (USAN/INN)
D02355 Tolmetin (USAN/INN)
D02709 Valdecoxib (USAN/INN); Bextra (TN)
D03163 Bromfenac sodium hydrate (JAN); Bromfenac sodium (USAN); Bromday (TN); Prolensa (TN); Xibrom (TN)
D03254 Flufenamate aluminum (JAN); Flufenamic acid aluminum; Opyrin (TN)
D03410 Carprofen (USAN/INN); Rimadyl (TN)
D03652 Darbufelone mesylate (USAN)
D03689 Deracoxib (USAN)
D03710 Etoricoxib (USAN/INN)
D03712 Firocoxib (USAN/INN); Equioxx (TN) [veterinary]
D03714 Lumiracoxib (USAN/INN)
D03715 Dexibuprofen (USAN/INN)
D03716 Parecoxib (USAN/INN)
D03717 Parecoxib sodium (USAN)
D03718 Dexibuprofen lysine (USAN); Doctrin (TN)
D04102 Etofenamate (USAN/INN)
D04490 Ibuprofen aluminum (USAN)
D04863 Mavacoxib (USAN)
D05143 Nepafenac (JAN/USAN/INN); Nevanac (TN)
D05181 Aspirin aluminum (JP16)
D05319 Oxyphenbutazone hydrate; Tandearil (TN)
D05451 Phenbutazone sodium glycerate (USAN)
D05511 Piroxicam betadex (USAN)
D05512 Piroxicam cinnamate (USAN)
D05513 Piroxicam olamine (USAN)
D05598 Pravadoline maleate (USAN)
D06606 Ibuprofen lysine (USAN); Solufenum; Neoprofen (TN)
D07141 Indobufen (INN)
D07269 Dexketoprofen (INN)
D07421 Aloxiprin (INN); Superpyrin (TN)
D07443 Amfenac (INN)
D07516 Benzydamine (INN); Apo-Benzydamine (TN)
D07517 Benzydamine salicylate; Fulgium (TN)
D07541 Bromfenac (INN)
D07579 Aspirin calcium salt; Notras (TN)
D07580 Aspirin DL-lysine (JAN); Aspirin lysine salt; Aspegic (TN)
D07581 Aspirin magnesium salt; Mobidin (TN)
D07582 Aspirin sodium; Sodium acetylsalicylate; Catalgine (TN)
D07816 Diclofenac (INN); Solaraze (TN)
D07817 Diclofenac diethylamine; Voltaren Emulgel (TN)
D07818 Diclofenac hydroxyethylpyrrolidine; Flector (TN)
D07819 Diclofenac calcium; Voltaren Actingo Extra (TN)
D07888 Eltenac (INN); Telzenac (TN)
D08058 Ibuprofen arginine salt; Zafen (TN)
D08059 Ibuprofen sodium; Ibuprofen sodium anhydrous; Esprenit (TN)
D08102 Ketoprofen lysine; Artrosilene (TN)
D08103 Ketoprofen sodium; Orudis (TN)
D08104 Ketorolac (INN); Toradol (TN)
D08149 Loxoprofen (INN)
D08162 Meclofenamate sodium; Meclomen (TN)
D08275 Niflumic acid (INN); Niflugel (TN)
D08324 Oxyphenbutazone (INN); Reozon (TN); Oxyphenbutazone (TN)
D08363 Phenylbutazone calcium; Peralgin (TN)
D08364 Phenylbutazone sodium; Ambene (TN)
D08374 Piketoprofen (INN); Calmatel (TN)
D08375 Piketoprofen hydrochloride; Triparsean (TN)
D08427 Proglumetacin (INN); Bruxel (TN)
D08657 Apricoxib (USAN/INN)
D09760 Ibuprofen sodium (USAN); Ibuprofen sodium hydrate
D10017 Naproxen etemesil (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PGH2_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycosylation regulates turnover of cyclooxygenase-2.";
Sevigny M.B., Li C.F., Alas M., Hughes-Fulford M.;
FEBS Lett. 580:6533-6536(2006).
Cited for: GLYCOSYLATION AT ASN-580.

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