PGH1_HUMAN - dbPTM
PGH1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PGH1_HUMAN
UniProt AC P23219
Protein Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Organism Homo sapiens (Human).
Sequence Length 599
Subcellular Localization Microsome membrane
Peripheral membrane protein. Endoplasmic reticulum membrane
Peripheral membrane protein.
Protein Description Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells..
Protein Sequence MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
54PhosphorylationVRFGLDRYQCDCTRT
EEECCCEEEECCCCC
17.11-
67N-linked_GlycosylationRTGYSGPNCTIPGLW
CCCCCCCCCCCCCHH
38.80UniProtKB CARBOHYD
84PhosphorylationLRNSLRPSPSFTHFL
HHHCCCCCCCCHHHH
27.0922210691
86PhosphorylationNSLRPSPSFTHFLLT
HCCCCCCCCHHHHHH
47.3022210691
88PhosphorylationLRPSPSFTHFLLTHG
CCCCCCCHHHHHHCC
18.9622210691
93PhosphorylationSFTHFLLTHGRWFWE
CCHHHHHHCCHHHHH
25.1622210691
103N-linked_GlycosylationRWFWEFVNATFIREM
HHHHHHHCHHHHHHH
38.29UniProtKB CARBOHYD
117PhosphorylationMLMRLVLTVRSNLIP
HHHHHHHHHHHCCCC
13.3428290473
143N-linked_GlycosylationISWESFSNVSYYTRI
CCHHHCCCCCEEEEE
25.41UniProtKB CARBOHYD
143N-linked_GlycosylationISWESFSNVSYYTRI
CCHHHCCCCCEEEEE
25.418121489
145PhosphorylationWESFSNVSYYTRILP
HHHCCCCCEEEEECC
19.3722210691
146PhosphorylationESFSNVSYYTRILPS
HHCCCCCEEEEECCC
12.4622210691
220PhosphorylationGKMGPGFTKALGHGV
CCCCCCHHHHHCCCC
22.7123532336
233PhosphorylationGVDLGHIYGDNLERQ
CCCHHHHCCCCHHHH
16.8623532336
384NitrationAMEFNHLYHWHPLMP
EECCCCHHCCCCCCC
8.70-
409N-linked_GlycosylationSYEQFLFNTSMLVDY
EHHHHHCCHHHHHHH
33.138121489
409N-linked_GlycosylationSYEQFLFNTSMLVDY
EHHHHHCCHHHHHHH
33.13-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PGH1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PGH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PGH1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTGIS_HUMANPTGISphysical
21035466
CAV1_HUMANCAV1physical
15230350
CAV2_HUMANCAV2physical
15230350
PGH2_HUMANPTGS2physical
18838483

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00109 Aspirin (JP16/USP); Aspalon (JAN); Acetylsalicylic acid; Easprin (TN)
D00118 Naproxen (JP16/USP/INN); Naprosyn (TN)
D00120 Sulindac (JP16/USP/INN); Clinoril (TN)
D00126 Ibuprofen (JP16/USP/INN); Advil (TN); Motrin (TN)
D00127 Piroxicam (JP16/USP/INN); Feldene (TN)
D00130 Diflunisal (JAN/USP/INN); Dolobid (TN)
D00132 Ketoprofen (JP16/USP/INN); Orudis (TN)
D00141 Indometacin (JP16/INN); Indomethacin (USP); Aconip (TN); Indocin (TN)
D00151 Mefenamic acid (JP16/USP/INN); Ponstel (TN)
D00158 Tolmetin sodium (JAN/USP); Tolmetin sodium dihydrate; Tolectin (TN)
D00169 Meclofenamate sodium (USP); Meclofenamate sodium monohydrate; Meclomen (TN)
D00330 Flurbiprofen (JP16/USP/INN); Ansaid (TN)
D00428 Sasapyrine (JAN); Salsalate (USP/INN); Disalcid (TN)
D00463 Oxaprozin (JP16/USAN/INN); Daypro (TN)
D00510 Phenylbutazone (JP16/USP/INN); Azolid (TN)
D00566 Sodium salicylate (JP16/USP); Salsonin (TN)
D00810 Choline salicylate (JAN/USAN/INN); Arthropan (TN)
D00813 Ketorolac tromethamine (USP); Acular (TN); Toradol (TN)
D00827 Magnesium salicylate (USP); Magnesium salicylate tetrahydrate; Magan (TN)
D00903 Diclofenac potassium (USAN); Cambia (TN); Cataflam (TN); Zipsor (TN)
D00904 Diclofenac sodium (JP16/USP); Solaraze (TN); Voltaren (TN)
D00968 Fenoprofen calcium (JAN/USP); Nalfon (TN)
D00970 Naproxen sodium (USP); Anaprox (TN)
D01122 Ibuprofen piconol (JP16/USAN); Staderm (TN)
D01183 Tolfenamic acid (JAN/INN); Clotam (TN)
D01325 Tiaprofenic acid (JAN/INN); Surgam (TN)
D01397 Ampiroxicam (JAN/INN); Flucam (TN)
D01410 Benzydamine hydrochloride (JAN/USAN); Tantum (TN)
D01475 Flurbiprofen axetil (JAN); FP 83; Ropion (TN)
D01513 Alminoprofen (JP16/INN); Minalfen (TN)
D01547 Zaltoprofen (JP16/INN); CN 100; Peon (TN)
D01565 Indometacin farnesil (JAN); Infree (TN)
D01578 Pranoprofen (JP16/INN); Elicapric (TN)
D01581 Flufenamic acid (JAN/USAN/INN); Arlef (TN)
D01582 Acemetacin (JP16/INN); Rantudil (TN)
D01675 Felbinac (JP16/USAN/INN); Dolinac (TN); Felbinac (TN)
D01709 Loxoprofen sodium hydrate (JP16); Lorfenamin (TN); Loxonin (TN)
D01718 Mofezolac (JAN/INN); Mofezolac (TN)
D01765 Proglumetacin maleate (JAN); Miridacin (TN)
D01767 Tenoxicam (JAN/USAN/INN); Tilcotil (TN)
D01788 Amfenac sodium hydrate (JAN); Amfenac sodium (USAN); Fenazox (TN)
D01811 Salicylamide (JAN/USP/INN); Salicylamide (TN)
D01841 Felbinac ethyl (JAN); LM 001
D01866 Lornoxicam (JAN/USAN/INN); Lorcam (TN)
D02110 Indometacin sodium (JAN); Indomethacin sodium (USP); Indomethacin sodium trihydrate; Indocin I.V. (T
D02290 Flurbiprofen sodium (USP); Ocufen (TN)
D02341 Meclofenamic acid (USAN/INN)
D02350 Fenoprofen (USAN/INN)
D02355 Tolmetin (USAN/INN)
D03254 Flufenamate aluminum (JAN); Flufenamic acid aluminum; Opyrin (TN)
D03410 Carprofen (USAN/INN); Rimadyl (TN)
D03712 Firocoxib (USAN/INN); Equioxx (TN) [veterinary]
D03715 Dexibuprofen (USAN/INN)
D03718 Dexibuprofen lysine (USAN); Doctrin (TN)
D04102 Etofenamate (USAN/INN)
D04490 Ibuprofen aluminum (USAN)
D05143 Nepafenac (JAN/USAN/INN); Nevanac (TN)
D05181 Aspirin aluminum (JP16)
D05319 Oxyphenbutazone hydrate; Tandearil (TN)
D05451 Phenbutazone sodium glycerate (USAN)
D05511 Piroxicam betadex (USAN)
D05512 Piroxicam cinnamate (USAN)
D05513 Piroxicam olamine (USAN)
D05598 Pravadoline maleate (USAN)
D06606 Ibuprofen lysine (USAN); Solufenum; Neoprofen (TN)
D07141 Indobufen (INN)
D07142 Triflusal (INN)
D07269 Dexketoprofen (INN)
D07421 Aloxiprin (INN); Superpyrin (TN)
D07443 Amfenac (INN)
D07516 Benzydamine (INN); Apo-Benzydamine (TN)
D07517 Benzydamine salicylate; Fulgium (TN)
D07579 Aspirin calcium salt; Notras (TN)
D07580 Aspirin DL-lysine (JAN); Aspirin lysine salt; Aspegic (TN)
D07581 Aspirin magnesium salt; Mobidin (TN)
D07582 Aspirin sodium; Sodium acetylsalicylate; Catalgine (TN)
D07816 Diclofenac (INN); Solaraze (TN)
D07817 Diclofenac diethylamine; Voltaren Emulgel (TN)
D07818 Diclofenac hydroxyethylpyrrolidine; Flector (TN)
D07819 Diclofenac calcium; Voltaren Actingo Extra (TN)
D08058 Ibuprofen arginine salt; Zafen (TN)
D08059 Ibuprofen sodium; Ibuprofen sodium anhydrous; Esprenit (TN)
D08102 Ketoprofen lysine; Artrosilene (TN)
D08103 Ketoprofen sodium; Orudis (TN)
D08104 Ketorolac (INN); Toradol (TN)
D08149 Loxoprofen (INN)
D08162 Meclofenamate sodium; Meclomen (TN)
D08324 Oxyphenbutazone (INN); Reozon (TN); Oxyphenbutazone (TN)
D08363 Phenylbutazone calcium; Peralgin (TN)
D08364 Phenylbutazone sodium; Ambene (TN)
D08374 Piketoprofen (INN); Calmatel (TN)
D08375 Piketoprofen hydrochloride; Triparsean (TN)
D08427 Proglumetacin (INN); Bruxel (TN)
D09760 Ibuprofen sodium (USAN); Ibuprofen sodium hydrate
D10017 Naproxen etemesil (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PGH1_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP