UniProt ID | PGH1_HUMAN | |
---|---|---|
UniProt AC | P23219 | |
Protein Name | Prostaglandin G/H synthase 1 | |
Gene Name | PTGS1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 599 | |
Subcellular Localization |
Microsome membrane Peripheral membrane protein. Endoplasmic reticulum membrane Peripheral membrane protein. |
|
Protein Description | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.. | |
Protein Sequence | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
54 | Phosphorylation | VRFGLDRYQCDCTRT EEECCCEEEECCCCC | 17.11 | - | |
67 | N-linked_Glycosylation | RTGYSGPNCTIPGLW CCCCCCCCCCCCCHH | 38.80 | UniProtKB CARBOHYD | |
84 | Phosphorylation | LRNSLRPSPSFTHFL HHHCCCCCCCCHHHH | 27.09 | 22210691 | |
86 | Phosphorylation | NSLRPSPSFTHFLLT HCCCCCCCCHHHHHH | 47.30 | 22210691 | |
88 | Phosphorylation | LRPSPSFTHFLLTHG CCCCCCCHHHHHHCC | 18.96 | 22210691 | |
93 | Phosphorylation | SFTHFLLTHGRWFWE CCHHHHHHCCHHHHH | 25.16 | 22210691 | |
103 | N-linked_Glycosylation | RWFWEFVNATFIREM HHHHHHHCHHHHHHH | 38.29 | UniProtKB CARBOHYD | |
117 | Phosphorylation | MLMRLVLTVRSNLIP HHHHHHHHHHHCCCC | 13.34 | 28290473 | |
143 | N-linked_Glycosylation | ISWESFSNVSYYTRI CCHHHCCCCCEEEEE | 25.41 | UniProtKB CARBOHYD | |
143 | N-linked_Glycosylation | ISWESFSNVSYYTRI CCHHHCCCCCEEEEE | 25.41 | 8121489 | |
145 | Phosphorylation | WESFSNVSYYTRILP HHHCCCCCEEEEECC | 19.37 | 22210691 | |
146 | Phosphorylation | ESFSNVSYYTRILPS HHCCCCCEEEEECCC | 12.46 | 22210691 | |
220 | Phosphorylation | GKMGPGFTKALGHGV CCCCCCHHHHHCCCC | 22.71 | 23532336 | |
233 | Phosphorylation | GVDLGHIYGDNLERQ CCCHHHHCCCCHHHH | 16.86 | 23532336 | |
384 | Nitration | AMEFNHLYHWHPLMP EECCCCHHCCCCCCC | 8.70 | - | |
409 | N-linked_Glycosylation | SYEQFLFNTSMLVDY EHHHHHCCHHHHHHH | 33.13 | 8121489 | |
409 | N-linked_Glycosylation | SYEQFLFNTSMLVDY EHHHHHCCHHHHHHH | 33.13 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PGH1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PGH1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PGH1_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PTGIS_HUMAN | PTGIS | physical | 21035466 | |
CAV1_HUMAN | CAV1 | physical | 15230350 | |
CAV2_HUMAN | CAV2 | physical | 15230350 | |
PGH2_HUMAN | PTGS2 | physical | 18838483 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
D00109 | Aspirin (JP16/USP); Aspalon (JAN); Acetylsalicylic acid; Easprin (TN) | |||||
D00118 | Naproxen (JP16/USP/INN); Naprosyn (TN) | |||||
D00120 | Sulindac (JP16/USP/INN); Clinoril (TN) | |||||
D00126 | Ibuprofen (JP16/USP/INN); Advil (TN); Motrin (TN) | |||||
D00127 | Piroxicam (JP16/USP/INN); Feldene (TN) | |||||
D00130 | Diflunisal (JAN/USP/INN); Dolobid (TN) | |||||
D00132 | Ketoprofen (JP16/USP/INN); Orudis (TN) | |||||
D00141 | Indometacin (JP16/INN); Indomethacin (USP); Aconip (TN); Indocin (TN) | |||||
D00151 | Mefenamic acid (JP16/USP/INN); Ponstel (TN) | |||||
D00158 | Tolmetin sodium (JAN/USP); Tolmetin sodium dihydrate; Tolectin (TN) | |||||
D00169 | Meclofenamate sodium (USP); Meclofenamate sodium monohydrate; Meclomen (TN) | |||||
D00330 | Flurbiprofen (JP16/USP/INN); Ansaid (TN) | |||||
D00428 | Sasapyrine (JAN); Salsalate (USP/INN); Disalcid (TN) | |||||
D00463 | Oxaprozin (JP16/USAN/INN); Daypro (TN) | |||||
D00510 | Phenylbutazone (JP16/USP/INN); Azolid (TN) | |||||
D00566 | Sodium salicylate (JP16/USP); Salsonin (TN) | |||||
D00810 | Choline salicylate (JAN/USAN/INN); Arthropan (TN) | |||||
D00813 | Ketorolac tromethamine (USP); Acular (TN); Toradol (TN) | |||||
D00827 | Magnesium salicylate (USP); Magnesium salicylate tetrahydrate; Magan (TN) | |||||
D00903 | Diclofenac potassium (USAN); Cambia (TN); Cataflam (TN); Zipsor (TN) | |||||
D00904 | Diclofenac sodium (JP16/USP); Solaraze (TN); Voltaren (TN) | |||||
D00968 | Fenoprofen calcium (JAN/USP); Nalfon (TN) | |||||
D00970 | Naproxen sodium (USP); Anaprox (TN) | |||||
D01122 | Ibuprofen piconol (JP16/USAN); Staderm (TN) | |||||
D01183 | Tolfenamic acid (JAN/INN); Clotam (TN) | |||||
D01325 | Tiaprofenic acid (JAN/INN); Surgam (TN) | |||||
D01397 | Ampiroxicam (JAN/INN); Flucam (TN) | |||||
D01410 | Benzydamine hydrochloride (JAN/USAN); Tantum (TN) | |||||
D01475 | Flurbiprofen axetil (JAN); FP 83; Ropion (TN) | |||||
D01513 | Alminoprofen (JP16/INN); Minalfen (TN) | |||||
D01547 | Zaltoprofen (JP16/INN); CN 100; Peon (TN) | |||||
D01565 | Indometacin farnesil (JAN); Infree (TN) | |||||
D01578 | Pranoprofen (JP16/INN); Elicapric (TN) | |||||
D01581 | Flufenamic acid (JAN/USAN/INN); Arlef (TN) | |||||
D01582 | Acemetacin (JP16/INN); Rantudil (TN) | |||||
D01675 | Felbinac (JP16/USAN/INN); Dolinac (TN); Felbinac (TN) | |||||
D01709 | Loxoprofen sodium hydrate (JP16); Lorfenamin (TN); Loxonin (TN) | |||||
D01718 | Mofezolac (JAN/INN); Mofezolac (TN) | |||||
D01765 | Proglumetacin maleate (JAN); Miridacin (TN) | |||||
D01767 | Tenoxicam (JAN/USAN/INN); Tilcotil (TN) | |||||
D01788 | Amfenac sodium hydrate (JAN); Amfenac sodium (USAN); Fenazox (TN) | |||||
D01811 | Salicylamide (JAN/USP/INN); Salicylamide (TN) | |||||
D01841 | Felbinac ethyl (JAN); LM 001 | |||||
D01866 | Lornoxicam (JAN/USAN/INN); Lorcam (TN) | |||||
D02110 | Indometacin sodium (JAN); Indomethacin sodium (USP); Indomethacin sodium trihydrate; Indocin I.V. (T | |||||
D02290 | Flurbiprofen sodium (USP); Ocufen (TN) | |||||
D02341 | Meclofenamic acid (USAN/INN) | |||||
D02350 | Fenoprofen (USAN/INN) | |||||
D02355 | Tolmetin (USAN/INN) | |||||
D03254 | Flufenamate aluminum (JAN); Flufenamic acid aluminum; Opyrin (TN) | |||||
D03410 | Carprofen (USAN/INN); Rimadyl (TN) | |||||
D03712 | Firocoxib (USAN/INN); Equioxx (TN) [veterinary] | |||||
D03715 | Dexibuprofen (USAN/INN) | |||||
D03718 | Dexibuprofen lysine (USAN); Doctrin (TN) | |||||
D04102 | Etofenamate (USAN/INN) | |||||
D04490 | Ibuprofen aluminum (USAN) | |||||
D05143 | Nepafenac (JAN/USAN/INN); Nevanac (TN) | |||||
D05181 | Aspirin aluminum (JP16) | |||||
D05319 | Oxyphenbutazone hydrate; Tandearil (TN) | |||||
D05451 | Phenbutazone sodium glycerate (USAN) | |||||
D05511 | Piroxicam betadex (USAN) | |||||
D05512 | Piroxicam cinnamate (USAN) | |||||
D05513 | Piroxicam olamine (USAN) | |||||
D05598 | Pravadoline maleate (USAN) | |||||
D06606 | Ibuprofen lysine (USAN); Solufenum; Neoprofen (TN) | |||||
D07141 | Indobufen (INN) | |||||
D07142 | Triflusal (INN) | |||||
D07269 | Dexketoprofen (INN) | |||||
D07421 | Aloxiprin (INN); Superpyrin (TN) | |||||
D07443 | Amfenac (INN) | |||||
D07516 | Benzydamine (INN); Apo-Benzydamine (TN) | |||||
D07517 | Benzydamine salicylate; Fulgium (TN) | |||||
D07579 | Aspirin calcium salt; Notras (TN) | |||||
D07580 | Aspirin DL-lysine (JAN); Aspirin lysine salt; Aspegic (TN) | |||||
D07581 | Aspirin magnesium salt; Mobidin (TN) | |||||
D07582 | Aspirin sodium; Sodium acetylsalicylate; Catalgine (TN) | |||||
D07816 | Diclofenac (INN); Solaraze (TN) | |||||
D07817 | Diclofenac diethylamine; Voltaren Emulgel (TN) | |||||
D07818 | Diclofenac hydroxyethylpyrrolidine; Flector (TN) | |||||
D07819 | Diclofenac calcium; Voltaren Actingo Extra (TN) | |||||
D08058 | Ibuprofen arginine salt; Zafen (TN) | |||||
D08059 | Ibuprofen sodium; Ibuprofen sodium anhydrous; Esprenit (TN) | |||||
D08102 | Ketoprofen lysine; Artrosilene (TN) | |||||
D08103 | Ketoprofen sodium; Orudis (TN) | |||||
D08104 | Ketorolac (INN); Toradol (TN) | |||||
D08149 | Loxoprofen (INN) | |||||
D08162 | Meclofenamate sodium; Meclomen (TN) | |||||
D08324 | Oxyphenbutazone (INN); Reozon (TN); Oxyphenbutazone (TN) | |||||
D08363 | Phenylbutazone calcium; Peralgin (TN) | |||||
D08364 | Phenylbutazone sodium; Ambene (TN) | |||||
D08374 | Piketoprofen (INN); Calmatel (TN) | |||||
D08375 | Piketoprofen hydrochloride; Triparsean (TN) | |||||
D08427 | Proglumetacin (INN); Bruxel (TN) | |||||
D09760 | Ibuprofen sodium (USAN); Ibuprofen sodium hydrate | |||||
D10017 | Naproxen etemesil (USAN) | |||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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