PTGIS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTGIS_HUMAN
• UniProt AC: Q16647
• Protein Name: Prostacyclin synthase
• Gene Name: PTGIS
• Organism: Homo sapiens (Human).
• Sequence Length: 500
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein .
• Protein Description: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)..
• Protein Sequence: MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	LLLSRRRTRRPGEPP HHHHHHCCCCCCCCC	29.26	22468782
52	Phosphorylation	DFGKDAASFLTRMKE HCCHHHHHHHHHHHH	23.62	-
83	Nitration	VLLDPHSYDAVVWEP EEECCCCCCEEEECC	12.60	-
116	Phosphorylation	DVQLPHYSPSDEKAR CCCCCCCCCCHHHHH	18.20	26657352
118	Phosphorylation	QLPHYSPSDEKARMK CCCCCCCCHHHHHHH	53.08	23312004
127	Phosphorylation	EKARMKLTLLHRELQ HHHHHHHHHHHHHHH	23.04	29396449
170	Phosphorylation	GLLDFSYSFLLRAGY CCCCCCHHHHHHCCC	14.28	24719451
200	Phosphorylation	QAQDRVHSADVFHTF HHHHHHHHHHHHHHH	24.25	-
221	Phosphorylation	LPKLARGSLSVGDKD HHHHHCCCCCCCCCC	16.36	28355574
390	Phosphorylation	LLLFPFLSPQRDPEI EEEEECCCCCCCCCC	21.26	24719451
398	Phosphorylation	PQRDPEIYTDPEVFK CCCCCCCCCCHHHHC	11.93	-
399	Phosphorylation	QRDPEIYTDPEVFKY CCCCCCCCCHHHHCC	51.22	-
421	Nitration	GSEKKDFYKDGKRLK CCCCCCCCCCCCCCC	20.50	-
430	Nitrated tyrosine	DGKRLKNYNMPWGAG CCCCCCCCCCCCCCC	15.96	-
430	Nitration	DGKRLKNYNMPWGAG CCCCCCCCCCCCCCC	15.96	12562775

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTGIS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTGIS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTGIS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CAV1_HUMAN	CAV1	physical	11339822

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 145500: Essential hypertension (EHT)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01240: Epoprostenol
• DB00812: Phenylbutazone