AGTR1_HUMAN - dbPTM
AGTR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AGTR1_HUMAN
UniProt AC P30556
Protein Name Type-1 angiotensin II receptor
Gene Name AGTR1
Organism Homo sapiens (Human).
Sequence Length 359
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system..
Protein Sequence MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4N-linked_Glycosylation----MILNSSTEDGI
----CCCCCCCHHHH		24.0019139490
5Phosphorylation---MILNSSTEDGIK
---CCCCCCCHHHHH		34.8824043423
6Phosphorylation--MILNSSTEDGIKR
--CCCCCCCHHHHHH		34.4424043423
7Phosphorylation-MILNSSTEDGIKRI
-CCCCCCCHHHHHHH		37.6124043423
26PhosphorylationPKAGRHNYIFVMIPT
CCCCCCCCEEEECCH		6.93-
127PhosphorylationTCLSIDRYLAIVHPM
HHHCHHHHHHHHCCC		9.2028509920
136PhosphorylationAIVHPMKSRLRRTML
HHHCCCCHHHHHHHH		30.2323403867
176N-linked_GlycosylationVFFIENTNITVCAFH
EEEEECCCEEEEEEE		39.24UniProtKB CARBOHYD
188N-linked_GlycosylationAFHYESQNSTLPIGL
EEEECCCCCCCCCCC		46.36UniProtKB CARBOHYD
230UbiquitinationKKAYEIQKNKPRNDD
HHHHHHHCCCCCCHH		73.01-
265UbiquitinationIFTFLDVLIQLGIIR
HHHHHHHHHHCCCCC		1.74-
289S-nitrosylationTAMPITICIAYFNNC
CCCCHHHHHHHHHCC		0.7922178444
289S-nitrosocysteineTAMPITICIAYFNNC
CCCCHHHHHHHHHCC		0.79-
302PhosphorylationNCLNPLFYGFLGKKF
CCCCHHHHHHHHHHH		18.0412436935
312PhosphorylationLGKKFKRYFLQLLKY
HHHHHHHHHHHHHHH		14.8326074081
319PhosphorylationYFLQLLKYIPPKAKS
HHHHHHHHCCCCCCC		20.739516477
326PhosphorylationYIPPKAKSHSNLSTK
HCCCCCCCCCCCCHH		36.6926074081
328PhosphorylationPPKAKSHSNLSTKMS
CCCCCCCCCCCHHHC		46.7026074081
331PhosphorylationAKSHSNLSTKMSTLS
CCCCCCCCHHHCEEC		30.1726074081
332PhosphorylationKSHSNLSTKMSTLSY
CCCCCCCHHHCEECC		33.6526074081
335PhosphorylationSNLSTKMSTLSYRPS
CCCCHHHCEECCCCC		27.9630242111
336PhosphorylationNLSTKMSTLSYRPSD
CCCHHHCEECCCCCC		19.0730242111
337PhosphorylationLSTKMSTLSYRPSDN
CCHHHCEECCCCCCC		3.1212436935
338PhosphorylationSTKMSTLSYRPSDNV
CHHHCEECCCCCCCC		21.1330242111
339PhosphorylationTKMSTLSYRPSDNVS
HHHCEECCCCCCCCC		29.6527251275
342PhosphorylationSTLSYRPSDNVSSST
CEECCCCCCCCCCCC		32.5827251275
346PhosphorylationYRPSDNVSSSTKKPA
CCCCCCCCCCCCCCC		25.4830242111
347PhosphorylationRPSDNVSSSTKKPAP
CCCCCCCCCCCCCCC		37.4327251275
348PhosphorylationPSDNVSSSTKKPAPC
CCCCCCCCCCCCCCC		36.4224719451
349PhosphorylationSDNVSSSTKKPAPCF
CCCCCCCCCCCCCCC		45.0627251275
354PhosphorylationSSTKKPAPCFEVE--
CCCCCCCCCCCCC--		31.6812522132
355S-palmitoylationSTKKPAPCFEVE---
CCCCCCCCCCCC---		5.02-
367Phosphorylation---------------
---------------		-
370Phosphorylation------------------
------------------		27251275
371Phosphorylation-------------------
-------------------		-
373Phosphorylation---------------------
---------------------		-
377Phosphorylation-------------------------
-------------------------		27251275
382Phosphorylation------------------------------
------------------------------		27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
319YPhosphorylationKinaseSRCP12931
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AGTR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AGTR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARBK1_HUMANADRBK1physical
9211925
GRK5_HUMANGRK5physical
9211925
BKRB2_HUMANBDKRB2physical
10993080
ATRAP_HUMANAGTRAPphysical
11733189
MK01_HUMANMAPK1physical
11226259
ARRB2_HUMANARRB2physical
11226259
JAK2_HUMANJAK2physical
11152457
ARRB1_HUMANARRB1physical
15611106
ARRB2_HUMANARRB2physical
15611106
RACK1_HUMANGNB2L1physical
18088317
CNCG_HUMANPDE6Hphysical
25416956
VKORL_HUMANVKORC1L1physical
26186194
AT12A_HUMANATP12Aphysical
26186194
AT2B4_HUMANATP2B4physical
26186194
AT2B3_HUMANATP2B3physical
26186194
PIGU_HUMANPIGUphysical
26186194
CLCC1_HUMANCLCC1physical
26186194
THOC7_HUMANTHOC7physical
26186194
SETD7_HUMANSETD7physical
26186194
SC6A8_HUMANSLC6A8physical
26186194
AG10A_HUMANALG10physical
26186194
CAV1_HUMANCAV1physical
26186194
S19A2_HUMANSLC19A2physical
26186194
CA112_HUMANC1orf112physical
26186194
TMM11_HUMANTMEM11physical
26186194
TSN15_HUMANTSPAN15physical
26186194
RAF1_HUMANRAF1physical
11226259
PF2R_HUMANPTGFRphysical
25512374
PGH2_HUMANPTGS2physical
25231994
SC6A8_HUMANSLC6A8physical
28514442
AT2B3_HUMANATP2B3physical
28514442
TMM11_HUMANTMEM11physical
28514442
CAV1_HUMANCAV1physical
28514442
DCX_HUMANDCXphysical
28514442
AT2B4_HUMANATP2B4physical
28514442
S19A2_HUMANSLC19A2physical
28514442
AT12A_HUMANATP12Aphysical
28514442
TSN15_HUMANTSPAN15physical
28514442
Drug and Disease Associations
Kegg Disease
H00575 Renal tubular dysgenesis
OMIM Disease
267430Renal tubular dysgenesis (RTD)
Kegg Drug
D00150 Angiotensin II (INN)
D00357 Losartan potassium (JP16/USAN); Cozaar (TN)
D00400 Valsartan (JP16/USAN/INN); Diovan (TN)
D00522 Candesartan (USAN/INN)
D00523 Irbesartan (JAN/USAN/INN); Avapro (TN)
D00626 Candesartan cilexetil (JP16/USAN); Atacand (TN)
D00627 Telmisartan (JAN/USAN/INN); Micardis (TN)
D01204 Olmesartan medoxomil (JAN/USAN); Benicar (TN); Olmetec (TN)
D01922 Pratosartan (JAN/INN); KD 3-671
D02014 Angiotensin II (human type) (JAN); Delivert (TN)
D02082 Eprosartan mesylate (USAN); Teveten (TN)
D02939 Angiotensin amide (USAN); Angiotensinamide (INN)
D04040 Eprosartan (USAN/INN)
D04126 Saralasin acetate (USAN); Sarenin (TN)
D04243 Forasartan (USAN/INN)
D05246 Olmesartan (USAN/INN)
D08067 Azilsartan medoxomil (USAN); Edarbi (TN)
D08146 Losartan (INN); Losartic (TN)
D08864 Azilsartan (JAN/USAN/INN); Azilva (TN)
D08865 Azilsartan kamedoxomil (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AGTR1_HUMAN

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Related Literatures of Post-Translational Modification

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