dbPTM

BKRB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BKRB2_HUMAN
UniProt AC	P30411
Protein Name	B2 bradykinin receptor
Gene Name	BDKRB2
Organism	Homo sapiens (Human).
Sequence Length	391
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system..
Protein Sequence	MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	WKISMFLSVREDSVP CEEEEEEEECCCCCC	14.09	25219547
17	Phosphorylation	FLSVREDSVPTTASF EEEECCCCCCCEEEE	25.83	-
30	N-linked_Glycosylation	SFSADMLNVTLQGPT EEECCCCCEEEECCC	20.35	UniProtKB CARBOHYD
39	N-linked_Glycosylation	TLQGPTLNGTFAQSK EEECCCCCCCCCCCC	50.35	UniProtKB CARBOHYD
156	Phosphorylation	MLVSIDRYLALVKTM HHHHHHHHHHHHHHH	7.80	10085087
162	Phosphorylation	RYLALVKTMSMGRMR HHHHHHHHHCCCCCC	13.65	22817900
177	Phosphorylation	GVRWAKLYSLVIWGC CHHHHHHHHHHHHHH	10.15	16226010
178	Phosphorylation	VRWAKLYSLVIWGCT HHHHHHHHHHHHHHH	26.96	-
207	N-linked_Glycosylation	EYSDEGHNVTACVIS HHCCCCCCEEEEEEC	43.63	UniProtKB CARBOHYD
260	Ubiquitination	NNEMQKFKEIQTERR HCCHHHHHHHHHHHH	62.03	33845483
324	S-palmitoylation	ASFMAYSNSCLNPLV HHHHHHCCCCCCCEE	24.86	11747451
329	S-palmitoylation	YSNSCLNPLVYVIVG HCCCCCCCEEEEEEC	15.39	11747451
332	Phosphorylation	SCLNPLVYVIVGKRF CCCCCEEEEEECCHH	7.67	22817900
347	Phosphorylation	RKKSWEVYQGVCQKG HHCCHHHHHHHCCCC	6.50	16226010
351	S-palmitoylation	WEVYQGVCQKGGCRS HHHHHHHCCCCCCCC	4.41	-
358	Phosphorylation	CQKGGCRSEPIQMEN CCCCCCCCCCEECCC	52.37	10085087
366	Phosphorylation	EPIQMENSMGTLRTS CCEECCCCCCCHHHH	12.79	29396449
369	Phosphorylation	QMENSMGTLRTSISV ECCCCCCCHHHHHHH	12.39	29396449
372	Phosphorylation	NSMGTLRTSISVERQ CCCCCHHHHHHHHHH	33.26	26699800
373	Phosphorylation	SMGTLRTSISVERQI CCCCHHHHHHHHHHH	13.36	23927012
375	Phosphorylation	GTLRTSISVERQIHK CCHHHHHHHHHHHHH	20.07	8394991
382	Ubiquitination	SVERQIHKLQDWAGS HHHHHHHHHHHHHCC	49.85	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
177	Y	Phosphorylation	Kinase	SRC	P12931	PSP
177	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
347	Y	Phosphorylation	Kinase	SRC	P12931	PSP
347	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
366	S	Phosphorylation	Kinase	GRK4	P32298	PSP
373	S	Phosphorylation	Kinase	GRK4	P32298	PSP
373	S	Phosphorylation	Kinase	GRK6	P43250	Uniprot
373	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
373	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
373	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
375	S	Phosphorylation	Kinase	GRK4	P32298	PSP
375	S	Phosphorylation	Kinase	GRK6	P43250	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BKRB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BKRB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NOS1_HUMAN	NOS1	physical	10681501
ACE_HUMAN	ACE	physical	17077303

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D03677	Deltibant (USAN/INN)
D04492	Icatibant acetate (USAN); Firazyr (TN)
D08937	Labradimil (INN/USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BKRB2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Determination of bradykinin B2 receptor in vivo phosphorylation sitesand their role in receptor function."; Blaukat A., Pizard A., Breit A., Wernstedt C., Alhenc-Gelas F.,Muller-Esterl W., Dikic I.; J. Biol. Chem. 276:40431-40440(2001). Cited for: PHOSPHORYLATION AT SER-373 AND SER-375.	11517230 [Abstract]