NOS1_HUMAN - dbPTM
NOS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOS1_HUMAN
UniProt AC P29475
Protein Name Nitric oxide synthase, brain
Gene Name NOS1
Organism Homo sapiens (Human).
Sequence Length 1434
Subcellular Localization Cell membrane, sarcolemma
Peripheral membrane protein. Cell projection, dendritic spine. In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enri
Protein Description Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR..
Protein Sequence MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQVDRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24AcetylationSVRLFKRKVGGLGFL
EEEEEEEECCCEEEE		45.9118415985
33AcetylationGGLGFLVKERVSKPP
CCEEEEEECCCCCCC		41.7818415985
38AcetylationLVKERVSKPPVIISD
EEECCCCCCCEEEHH		50.9518415985
116PhosphorylationTTFTGDGTPKTIRVT
EEECCCCCCCEEEEE		26.7626437602
131AcetylationQPLGPPTKAVDLSHQ
ECCCCCCCEEECCCC		52.7918415985
195PhosphorylationAKKATRVSLQGRGEN
HHHCCEEEECCCCCC		16.2226437602
234AcetylationAPAKAEMKDMGIQVD
CCCCHHHHHCCCEEC		35.7518415985
248PhosphorylationDRDLDGKSHKPLPLG
CCCCCCCCCCCCCCC		42.1230622161
250AcetylationDLDGKSHKPLPLGVE
CCCCCCCCCCCCCCC		56.1718415985
292PhosphorylationPPTSGKQSPTKNGSP
CCCCCCCCCCCCCCC		37.7122496350
294PhosphorylationTSGKQSPTKNGSPSK
CCCCCCCCCCCCCCC		42.2522617229
320 (in isoform 4)Phosphorylation-15.7322468782
324 (in isoform 4)Phosphorylation-30.5522468782
327 (in isoform 4)Phosphorylation-7.7728634120
329 (in isoform 4)Phosphorylation-40.4428634120
356UbiquitinationRPEDVRTKGQLFPLA
CCHHHHCHHHHHHHH		33.81-
370PhosphorylationAKEFIDQYYSSIKRF
HHHHHHHHHHHHHHH		11.1030576142
372PhosphorylationEFIDQYYSSIKRFGS
HHHHHHHHHHHHHCC		22.2030576142
378 (in isoform 4)Phosphorylation-32.0625690035
395PhosphorylationEVNKEIDTTSTYQLK
HHHHHCCCCCEEECC		28.45-
396PhosphorylationVNKEIDTTSTYQLKD
HHHHCCCCCEEECCC		18.4718452278
397PhosphorylationNKEIDTTSTYQLKDT
HHHCCCCCEEECCCH		27.49-
453PhosphorylationYICNHVKYATNKGNL
HHHHHHHHHCCCCCC		19.98-
603PhosphorylationTEIGVRDYCDNSRYN
CEEECCCCCCCCCHH		7.3722210691
607PhosphorylationVRDYCDNSRYNILEE
CCCCCCCCCHHHHHH		23.9222210691
609PhosphorylationDYCDNSRYNILEEVA
CCCCCCCHHHHHHHH		13.3316690617
662PhosphorylationDHHSATESFIKHMEN
CCCHHHHHHHHHHHH		28.1124719451
724PhosphorylationNTHVWKGTNGTPTKR
CCCEECCCCCCCCCC		27.09-
746PhosphorylationLAEAVKFSAKLMGQA
HHHHHHHHHHHHHHH		20.8315251453
759AcetylationQAMAKRVKATILYAT
HHHHHHHHEEEEEEC		43.7918415985
766PhosphorylationKATILYATETGKSQA
HEEEEEECCCCCCHH		22.11-
768PhosphorylationTILYATETGKSQAYA
EEEEECCCCCCHHHH		45.62-
852PhosphorylationSYKVRFNSVSSYSDS
HCEEEECCCCCCCCC		22.2126657352
854PhosphorylationKVRFNSVSSYSDSQK
EEEECCCCCCCCCCC		24.3124719451
855PhosphorylationVRFNSVSSYSDSQKS
EEECCCCCCCCCCCC		26.8822617229
857PhosphorylationFNSVSSYSDSQKSSG
ECCCCCCCCCCCCCC		32.5022617229
859PhosphorylationSVSSYSDSQKSSGDG
CCCCCCCCCCCCCCC		33.3022617229
861AcetylationSSYSDSQKSSGDGPD
CCCCCCCCCCCCCCC		51.0118415985
862PhosphorylationSYSDSQKSSGDGPDL
CCCCCCCCCCCCCCH		31.73-
863PhosphorylationYSDSQKSSGDGPDLR
CCCCCCCCCCCCCHH		48.19-
885PhosphorylationPLANVRFSVFGLGSR
CCCCCEEEEECCCCC		13.13-
888PhosphorylationNVRFSVFGLGSRAYP
CCEEEEECCCCCCCC		27.2924719451
994AcetylationQGLSNVHKKRVSAAR
HHCCHHHHHHHHHHH		37.6818415985
1010PhosphorylationLSRQNLQSPKSSRST
HHHCCCCCCCCCCCE		37.1426091039
1106PhosphorylationFKYYLDITTPPTPLQ
HHHHHCCCCCCCHHH		32.6826074081
1107PhosphorylationKYYLDITTPPTPLQL
HHHHCCCCCCCHHHH		27.8326074081
1110PhosphorylationLDITTPPTPLQLQQF
HCCCCCCCHHHHHHH		37.5226074081
1305AcetylationREETLQAKNKGVFRE
HHHHHHHHHHHHHHH		46.3518415985
1326AcetylationREPDKPKKYVQDILQ
CCCCCCHHHHHHHHH		60.2118415985
1358PhosphorylationIYVCGDVTMAADVLK
EEEECCHHHHHHHHH		13.06-
1376AcetylationRIMTQQGKLSAEDAG
HHHHHCCCCCHHHHC		34.6218415985
1378PhosphorylationMTQQGKLSAEDAGVF
HHHCCCCCHHHHCEE		32.85-
1387PhosphorylationEDAGVFISRMRDDNR
HHHCEEEEEECCCCC		14.46-
1415PhosphorylationEVTNRLRSESIAFIE
HHHHHHHHCEEEEEH		40.0423312004
1417PhosphorylationTNRLRSESIAFIEES
HHHHHHCEEEEEHHH		22.0626657352
1424PhosphorylationSIAFIEESKKDTDEV
EEEEEHHHHCCHHHH		32.0123312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
852SPhosphorylationKinaseCAMK2AQ9UQM7
GPS
-KUbiquitinationE3 ubiquitin ligaseSTUB1Q9UNE7
PMID:15466472
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CTBP1_RATCtbp1physical
11590170
CAPON_HUMANNOS1APphysical
9459447
DLG4_HUMANDLG4physical
9459447
DLG4_HUMANDLG4physical
8625413
DLG2_HUMANDLG2physical
8625413
CHIP_HUMANSTUB1physical
15466472
HSP74_HUMANHSPA4physical
15466472
BKRB2_HUMANBDKRB2physical
10681501
KPCD1_HUMANPRKD1physical
24740233
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D09018 Tilarginine acetate (USAN)
DrugBank
DB00997Doxorubicin
DB03147Flavin adenine dinucleotide
DB00155L-Citrulline
Regulatory Network of NOS1_HUMAN

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Related Literatures of Post-Translational Modification

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