CTBP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTBP1_RAT
• UniProt AC: Q9Z2F5
• Protein Name: C-terminal-binding protein 1
• Gene Name: Ctbp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 430
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation..
• Protein Sequence: MSGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYSRYPPGVVSVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHTTDQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Phosphorylation	REGTRVQSVEQIREV HHCCCCCCHHHHHHH	25.43	22366688
289	Phosphorylation	ESEPFSFSQGPLKDA CCCCCCCCCCCCCCC	32.79	-
412	Phosphorylation	AHPPHAPSPGQTVKP CCCCCCCCCCCCCCC	42.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
147	S	Phosphorylation	Kinase	PAK1	Q13153	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
412	S	Phosphorylation	Phosphorylation by HIPK2 on Ser-412 induces proteasomal degradation (By similarity).	-
418	K	Sumoylation	Sumoylation on Lys-418 is promoted by the E3 SUMO-protein ligase CBX4.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTBP1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOS1_RAT	Nos1	physical	11590170

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.