PF2R_HUMAN - dbPTM
PF2R_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PF2R_HUMAN
UniProt AC P43088
Protein Name Prostaglandin F2-alpha receptor
Gene Name PTGFR
Organism Homo sapiens (Human).
Sequence Length 359
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost..
Protein Sequence MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4N-linked_Glycosylation----MSMNNSKQLVS
----CCCCCHHHCCC		42.17UniProtKB CARBOHYD
19N-linked_GlycosylationPAAALLSNTTCQTEN
HHHHHHCCCCCCCCH		39.10UniProtKB CARBOHYD
177PhosphorylationPILGHRDYKIQASRT
HHCCCCCHHEEECCE		15.2222817900
294PhosphorylationLFALRMATWNQILDP
HHHHHHHHHHHHHCH		18.6630257219
336PhosphorylationSLHIWELSSIKNSLK
HHHHHHHHHCHHHCH		20.6424719451
341PhosphorylationELSSIKNSLKVAAIS
HHHHCHHHCHHHEEE		25.2728787133
350PhosphorylationKVAAISESPVAEKSA
HHHEEECCCCCHHHC		20.2029514088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PF2R_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PF2R_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PF2R_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PF2R_HUMANPTGFRphysical
18587449
NFIP2_HUMANNDFIP2physical
26186194
MBOA7_HUMANMBOAT7physical
26186194
AT12A_HUMANATP12Aphysical
26186194
AT2B2_HUMANATP2B2physical
26186194
AT2B3_HUMANATP2B3physical
26186194
S20A2_HUMANSLC20A2physical
26186194
DNJC5_HUMANDNAJC5physical
26186194
ALG6_HUMANALG6physical
26186194
RHBD3_HUMANRHBDD3physical
26186194
NFIP1_HUMANNDFIP1physical
26186194
AGTR1_HUMANAGTR1physical
25512374
DNJC5_HUMANDNAJC5physical
28514442
AT2B3_HUMANATP2B3physical
28514442
AT2B2_HUMANATP2B2physical
28514442
NFIP1_HUMANNDFIP1physical
28514442
AT12A_HUMANATP12Aphysical
28514442
S20A2_HUMANSLC20A2physical
28514442
MBOA7_HUMANMBOAT7physical
28514442
YIPF4_HUMANYIPF4physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00081 Dinoprost (JP16/USAN/INN); Prosmon (TN)
D00356 Latanoprost (JAN/USAN/INN); Xalatan (TN)
D00682 Carboprost tromethamine (USP); Hemabate (TN)
D01352 Dinoprost tromethamine (JAN/USP); Prostin F2 alpha (TN)
D01452 Isopropyl unoprostone (JAN); Unoprostone isopropyl; Rescula (TN)
D01964 Travoprost (JAN/USAN/INN); Travatan (TN)
D02343 Carboprost (USAN/INN)
D02719 Rosaprostol (INN)
D02724 Bimatoprost (JAN/USAN/INN); Lumigan (TN)
D03399 Carboprost methyl (USAN)
D06274 Tafluprost (JAN/USAN/INN)
D08591 Tiaprost (INN); Iliren [veterinary] (TN)
D08661 Unoprostone (INN); Rescula (TN)
D10441 Latanoprostene bunod (USAN/INN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PF2R_HUMAN

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Related Literatures of Post-Translational Modification

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