ALG6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALG6_HUMAN
• UniProt AC: Q9Y672
• Protein Name: Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
• Gene Name: ALG6
• Organism: Homo sapiens (Human).
• Sequence Length: 507
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol..
• Protein Sequence: MEKWYLMTVVVLIGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITFNLPVKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILLYPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFSISVRKYLPCFTFLSRIIQYLFLISVITMVLLTLMTVTLDPPQKLPDLFSVLVCFVSCLNFLFFLVYFNIIIMWDSKSGRNQKKIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Ubiquitination	GYESQAHKLFMRTTV CHHHHHHHHHHHHHH	46.57	-
289	2-Hydroxyisobutyrylation	FNVFLKIKDILPRHI HHHHHHHHHHHHHHH	36.81	-
422	Phosphorylation	ELQLKSFSISVRKYL HHCHHEEEEHHHHHH	22.50	27251275
424	Phosphorylation	QLKSFSISVRKYLPC CHHEEEEHHHHHHHH	18.05	27251275
428	Phosphorylation	FSISVRKYLPCFTFL EEEHHHHHHHHHHHH	12.81	46162305
433	Phosphorylation	RKYLPCFTFLSRIIQ HHHHHHHHHHHHHHH	30.31	46162299
441	Phosphorylation	FLSRIIQYLFLISVI HHHHHHHHHHHHHHH	6.76	24043423
446	Phosphorylation	IQYLFLISVITMVLL HHHHHHHHHHHHHHH	15.04	24043423
449	Phosphorylation	LFLISVITMVLLTLM HHHHHHHHHHHHHHH	10.08	24043423
454	Phosphorylation	VITMVLLTLMTVTLD HHHHHHHHHHHCCCC	15.43	24043423
457	Phosphorylation	MVLLTLMTVTLDPPQ HHHHHHHHCCCCCCC	17.28	24043423
459	Phosphorylation	LLTLMTVTLDPPQKL HHHHHHCCCCCCCCC	19.10	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALG6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALG6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALG6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ALG6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.