CA112_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CA112_HUMAN
• UniProt AC: Q9NSG2
• Protein Name: Uncharacterized protein C1orf112
• Gene Name: C1orf112
• Organism: Homo sapiens (Human).
• Sequence Length: 853
• Protein Sequence: MFLPHMNHLTLEQTFFSQVLPKTVKLFDDMMYELTSQARGLSSQNLEIQTTLRNILQTMVQLLGALTGCVQHICATQESIILENIQSLPSSVLHIIKSTFVHCKNSESVYSGCLHLVSDLLQALFKEAYSLQKQLMELLDMVCMDPLVDDNDDILNMVIVIHSLLDICSVISSMDHAFHANTWKFIIKQSLKHQSIIKSQLKHKDIITSLCEDILFSFHSCLQLAEQMTQSDAQDNADYRLFQKTLKLCRFFANSLLHYAKEFLPFLSDSCCTLHQLYLQIHSKFPPSLYATRISKAHQEEIAGAFLVTLDPLISQLLTFQPFMQVVLDSKLDLPCELQFPQCLLLVVVMDKLPSQPKEVQTLWCTDSQVSETTTRISLLKAVFYSFEQCSGELSLPVHLQGLKSKGKAEVAVTLYQHVCVHLCTFITSFHPSLFAELDAALLNAVLSANMITSLLAMDAWCFLARYGTAELCAHHVTIVAHLIKSCPGECYQLINLSILLKRLFFFMAPPHQLEFIQKFSPKEAENLPLWQHISFQALPPELREQTVHEVTTVGTAECRKWLSRSRTLGELESLNTVLSALLAVCNSAGEALDTGKQTAIIEVVSQLWAFLNIKQVADQPYVQQTFSLLLPLLGFFIQTLDPKLILQAVTLQTSLLKLELPDYVRLAMLDFVSSLGKLFIPEAIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKNKVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEFPWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Ubiquitination	QVLPKTVKLFDDMMY HHHHHHCHHHHHHHH	48.98	21890473
25 (in isoform 1)	Ubiquitination	-	48.98	21890473
42	Phosphorylation	TSQARGLSSQNLEIQ HHHHCCCCCCCHHHH	32.47	20068231
43	Phosphorylation	SQARGLSSQNLEIQT HHHCCCCCCCHHHHH	28.29	20068231
51	Phosphorylation	QNLEIQTTLRNILQT CCHHHHHHHHHHHHH	13.82	23186163
129	Phosphorylation	QALFKEAYSLQKQLM HHHHHHHHHHHHHHH	15.82	24114839
188	Ubiquitination	NTWKFIIKQSLKHQS CHHHHHHHHHHHHHH	29.08	-
192	Ubiquitination	FIIKQSLKHQSIIKS HHHHHHHHHHHHHHH	44.86	-
195	Phosphorylation	KQSLKHQSIIKSQLK HHHHHHHHHHHHHHC	26.46	24719451
198	Ubiquitination	LKHQSIIKSQLKHKD HHHHHHHHHHHCCHH	30.40	-
244	Ubiquitination	ADYRLFQKTLKLCRF HHHHHHHHHHHHHHH	48.79	-
288	Phosphorylation	IHSKFPPSLYATRIS HHHHCCHHHHHHHCC	33.96	-
290	Phosphorylation	SKFPPSLYATRISKA HHCCHHHHHHHCCHH	15.40	-
292	Phosphorylation	FPPSLYATRISKAHQ CCHHHHHHHCCHHHH	18.25	-
373	Phosphorylation	TDSQVSETTTRISLL CCCCCCHHHHHHHHH	26.43	22210691
374	Phosphorylation	DSQVSETTTRISLLK CCCCCHHHHHHHHHH	15.27	22210691
378	Phosphorylation	SETTTRISLLKAVFY CHHHHHHHHHHHHHH	25.10	24719451
521	Phosphorylation	LEFIQKFSPKEAENL HHHHHHCCHHHHHCC	41.94	24719451
523	Ubiquitination	FIQKFSPKEAENLPL HHHHCCHHHHHCCCC	69.25	-
651	Phosphorylation	KLILQAVTLQTSLLK HHHHHHHHHCHHHHH	19.03	24961811
655	Phosphorylation	QAVTLQTSLLKLELP HHHHHCHHHHHCCCC	20.81	24719451
744	Phosphorylation	ETKNKVVSFLEKTGF HHHHHHHHHHHHCCC	27.40	24719451
748	Ubiquitination	KVVSFLEKTGFVDET HHHHHHHHCCCCCHH	56.97	-
759	Ubiquitination	VDETEAAKVERVKQE CCHHHHHHHHHHHHH	52.23	-
767	Ubiquitination	VERVKQEKGIFWEPF HHHHHHHCCCCCCCC	55.61	-
783	Ubiquitination	NVTVEEAKRSSLQPY CCCHHHHHHHCCHHH	56.97	-
785	Phosphorylation	TVEEAKRSSLQPYAK CHHHHHHHCCHHHHH	34.39	26270265
786	Phosphorylation	VEEAKRSSLQPYAKR HHHHHHHCCHHHHHH	34.75	25159151
790	Phosphorylation	KRSSLQPYAKRARQE HHHCCHHHHHHHHHH	16.28	26270265
792	Acetylation	SSLQPYAKRARQEFP HCCHHHHHHHHHHCC	40.52	19608861
792	Ubiquitination	SSLQPYAKRARQEFP HCCHHHHHHHHHHCC	40.52	19608861
818	Phosphorylation	IAGALEATESLLQKG HHHHHHHHHHHHHHC	19.41	29396449
820	Phosphorylation	GALEATESLLQKGPA HHHHHHHHHHHHCCC	29.99	29396449

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CA112_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CA112_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CA112_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
AL3A2_HUMAN	ALDH3A2	physical	26496610
TSSC4_HUMAN	TSSC4	physical	26496610
DEN4C_HUMAN	DENND4C	physical	26496610
FIGL1_HUMAN	FIGNL1	physical	26496610
SPA5L_HUMAN	SPATA5L1	physical	26496610
CE030_HUMAN	C5orf30	physical	26496610
TM263_HUMAN	TMEM263	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-792, AND MASS SPECTROMETRY.
PubMed: 19608861