| UniProt ID | TSN15_HUMAN | |
|---|---|---|
| UniProt AC | O95858 | |
| Protein Name | Tetraspanin-15 | |
| Gene Name | TSPAN15 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 294 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Late endosome membrane . |
|
| Protein Description | Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.. | |
| Protein Sequence | MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGALVLSVGIYAEVERQKYKTLESAFLAPAIILILLGVVMFMVSFIGVLASLRDNLYLLQAFMYILGICLIMELIGGVVALTFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSAPGPLACGVPYTCCIRNTTEVVNTMCGYKTIDKERFSVQDVIYVRGCTNAVIIWFMDNYTIMAGILLGILLPQFLGVLLTLLYITRVEDIIMEHSVTDGLLGPGAKPSVEAAGTGCCLCYPN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Phosphorylation | SYLWLKFSLIIYSTV HHHHHHHHHHHHHHH | 19.64 | - | |
| 29 | Phosphorylation | FSLIIYSTVFWLIGA HHHHHHHHHHHHHHH | 11.62 | - | |
| 84 | Phosphorylation | SFIGVLASLRDNLYL HHHHHHHHHHHHHHH | 21.56 | 24719451 | |
| 97 | Phosphorylation | YLLQAFMYILGICLI HHHHHHHHHHHHHHH | 6.12 | 22817900 | |
| 115 | Phosphorylation | IGGVVALTFRNQTID HCHHHHHHCCCCHHH | 15.71 | - | |
| 118 | N-linked_Glycosylation | VVALTFRNQTIDFLN HHHHHCCCCHHHHHH | 38.87 | UniProtKB CARBOHYD | |
| 189 | N-linked_Glycosylation | PYTCCIRNTTEVVNT CEEEEECCCHHHHHH | 31.29 | 17660510 | |
| 209 | Phosphorylation | TIDKERFSVQDVIYV CCCCCCCCCCCEEEE | 25.70 | 28842319 | |
| 215 | Phosphorylation | FSVQDVIYVRGCTNA CCCCCEEEECCCCCE | 5.50 | 28842319 | |
| 230 | N-linked_Glycosylation | VIIWFMDNYTIMAGI EEEEECCCHHHHHHH | 24.86 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TSN15_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TSN15_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TSN15_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SYNE4_HUMAN | SYNE4 | physical | 25416956 | |
| ADA10_HUMAN | ADAM10 | physical | 23091066 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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