dbPTM

CNCG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CNCG_HUMAN
UniProt AC	Q13956
Protein Name	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Gene Name	PDE6H
Organism	Homo sapiens (Human).
Sequence Length	83
Subcellular Localization
Protein Description	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones..
Protein Sequence	MSDNTTLPAPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDNTTLPA ------CCCCCCCCC	39.30	25072903
5	Phosphorylation	---MSDNTTLPAPAS ---CCCCCCCCCCCC	34.40	25072903
6	Phosphorylation	--MSDNTTLPAPASN --CCCCCCCCCCCCC	36.68	25072903
12	Phosphorylation	TTLPAPASNQGPTTP CCCCCCCCCCCCCCC	28.73	25072903
17	Phosphorylation	PASNQGPTTPRKGPP CCCCCCCCCCCCCCC	57.14	25072903
18	Phosphorylation	ASNQGPTTPRKGPPK CCCCCCCCCCCCCCC	24.99	25072903
32	Dimethylation	KFKQRQTRQFKSKPP CHHHHHHHHHCCCCC	31.44	-
32	Methylation	KFKQRQTRQFKSKPP CHHHHHHHHHCCCCC	31.44	24390065
58	Phosphorylation	PGMEGLGTDITVICP CCCCCCCCCEEEEEC	29.30	12624098

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CNCG_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CNCG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CNCG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049
COTL1_HUMAN	COTL1	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CNCG_HUMAN

Related Literatures of Post-Translational Modification