SC6A8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC6A8_HUMAN
• UniProt AC: P48029
• Protein Name: Sodium- and chloride-dependent creatine transporter 1
• Gene Name: SLC6A8
• Organism: Homo sapiens (Human).
• Sequence Length: 635
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Required for the uptake of creatine in muscles and brain..
• Protein Sequence: MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MAKKSAENGIY ----CCCCCCCCCCE	45.41	21906983
5	Phosphorylation	---MAKKSAENGIYS ---CCCCCCCCCCEE	39.86	21945579
11	Phosphorylation	KSAENGIYSVSGDEK CCCCCCCEECCCCCC	12.38	21945579
12	Phosphorylation	SAENGIYSVSGDEKK CCCCCCEECCCCCCC	14.11	21945579
14	Phosphorylation	ENGIYSVSGDEKKGP CCCCEECCCCCCCCC	34.29	21945579
18	Acetylation	YSVSGDEKKGPLIAP EECCCCCCCCCEECC	68.70	7481353
18	Ubiquitination	YSVSGDEKKGPLIAP EECCCCCCCCCEECC	68.70	21906983
19	Acetylation	SVSGDEKKGPLIAPG ECCCCCCCCCEECCC	64.81	12429819
19	Ubiquitination	SVSGDEKKGPLIAPG ECCCCCCCCCEECCC	64.81	1906983
33	Acetylation	GPDGAPAKGDGPVGL CCCCCCCCCCCCCCC	57.38	12429829
33	Ubiquitination	GPDGAPAKGDGPVGL CCCCCCCCCCCCCCC	57.38	21906983
42	Phosphorylation	DGPVGLGTPGGRLAV CCCCCCCCCCCCCCC	24.65	29255136
54	Phosphorylation	LAVPPRETWTRQMDF CCCCCHHHHHHHHHH	33.16	30576142
56	Phosphorylation	VPPRETWTRQMDFIM CCCHHHHHHHHHHHH	20.60	30576142
94 (in isoform 2)	Phosphorylation	-	10.82	28450419
95 (in isoform 2)	Phosphorylation	-	2.33	28450419
192	N-linked_Glycosylation	FRHEDCANASLANLT HCCHHHCCHHHCCCC	36.07	UniProtKB CARBOHYD
197	N-linked_Glycosylation	CANASLANLTCDQLA HCCHHHCCCCHHHHH	40.97	UniProtKB CARBOHYD
217	Ubiquitination	VIEFWENKVLRLSGG CHHHHHCCEEEECCC	31.00	21906983
361	Phosphorylation	FAGFVVFSILGFMAA HHHHHHHHHHHHHHH	12.80	22210691
548	N-linked_Glycosylation	YYEPLVYNNTYVYPW EECCEEECCEEEECC	27.21	UniProtKB CARBOHYD
614	Methylation	RAQDADVRGLTTLTP HCCCCCCCCCEEEEE	34.64	115917129
617	Phosphorylation	DADVRGLTTLTPVSE CCCCCCCEEEEECCC	23.68	30266825
618	Phosphorylation	ADVRGLTTLTPVSES CCCCCCEEEEECCCC	33.41	20363803
620	Phosphorylation	VRGLTTLTPVSESSK CCCCEEEEECCCCCE	21.39	30266825
623	Phosphorylation	LTTLTPVSESSKVVV CEEEEECCCCCEEEE	32.72	30266825
623	O-linked_Glycosylation	LTTLTPVSESSKVVV CEEEEECCCCCEEEE	32.72	28657654
625	Phosphorylation	TLTPVSESSKVVVVE EEEECCCCCEEEEEE	28.14	30266825
626	Phosphorylation	LTPVSESSKVVVVES EEECCCCCEEEEEEE	25.97	30266825
627	Ubiquitination	TPVSESSKVVVVESV EECCCCCEEEEEEEC	48.61	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC6A8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC6A8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC6A8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SC6A8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00480: Non-syndromic X-linked mental retardation
• H00577: Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Part
• H00849: Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT defici
• OMIM Disease
• 300352: Cerebral creatine deficiency syndrome 1 (CCDS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00148: Creatine

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-620, AND MASSSPECTROMETRY.
PubMed: 18691976