| UniProt ID | AT2B4_HUMAN | |
|---|---|---|
| UniProt AC | P23634 | |
| Protein Name | Plasma membrane calcium-transporting ATPase 4 {ECO:0000305} | |
| Gene Name | ATP2B4 {ECO:0000312|HGNC:HGNC:817} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1241 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cell projection, cilium, flagellum membrane Multi-pass membrane protein . |
|
| Protein Description | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. [PubMed: 8530416 By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity] | |
| Protein Sequence | MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTNPSDRVL ------CCCHHHCCC | 68.11 | 24719451 | |
| 5 | Phosphorylation | ---MTNPSDRVLPAN ---CCCHHHCCCCCH | 39.87 | 29083192 | |
| 13 | Phosphorylation | DRVLPANSMAESREG HCCCCCHHCCHHCCC | 22.83 | 29255136 | |
| 14 | Sulfoxidation | RVLPANSMAESREGD CCCCCHHCCHHCCCC | 4.87 | 21406390 | |
| 17 | Phosphorylation | PANSMAESREGDFGC CCHHCCHHCCCCCCC | 26.54 | 29255136 | |
| 27 | Sulfoxidation | GDFGCTVMELRKLME CCCCCHHHHHHHHHH | 1.85 | 21406390 | |
| 31 | Ubiquitination | CTVMELRKLMELRSR CHHHHHHHHHHHHCC | 65.88 | - | |
| 31 (in isoform 6) | Ubiquitination | - | 65.88 | - | |
| 59 | Ubiquitination | QNLCSRLKTSPVEGL HHHHHHCCCCCCCCC | 45.93 | 21906983 | |
| 59 (in isoform 1) | Ubiquitination | - | 45.93 | 21890473 | |
| 59 (in isoform 2) | Ubiquitination | - | 45.93 | 21890473 | |
| 59 (in isoform 3) | Ubiquitination | - | 45.93 | 21890473 | |
| 59 (in isoform 4) | Ubiquitination | - | 45.93 | 21890473 | |
| 59 (in isoform 5) | Ubiquitination | - | 45.93 | 21890473 | |
| 59 (in isoform 6) | Ubiquitination | - | 45.93 | 21890473 | |
| 59 (in isoform 7) | Ubiquitination | - | 45.93 | 21890473 | |
| 59 (in isoform 8) | Ubiquitination | - | 45.93 | 21890473 | |
| 67 | Phosphorylation | TSPVEGLSGNPADLE CCCCCCCCCCHHHHH | 47.59 | - | |
| 75 | Ubiquitination | GNPADLEKRRQVFGH CCHHHHHHHHHHHCC | 61.24 | 21906983 | |
| 75 (in isoform 1) | Ubiquitination | - | 61.24 | 21890473 | |
| 75 (in isoform 2) | Ubiquitination | - | 61.24 | 21890473 | |
| 75 (in isoform 3) | Ubiquitination | - | 61.24 | 21890473 | |
| 75 (in isoform 4) | Ubiquitination | - | 61.24 | 21890473 | |
| 75 (in isoform 5) | Ubiquitination | - | 61.24 | 21890473 | |
| 75 (in isoform 6) | Ubiquitination | - | 61.24 | 21890473 | |
| 75 (in isoform 7) | Ubiquitination | - | 61.24 | 21890473 | |
| 75 (in isoform 8) | Ubiquitination | - | 61.24 | 21890473 | |
| 189 | Ubiquitination | CRIEQEQKFSIIRNG CCCCHHHCEEEEECC | 40.08 | - | |
| 189 (in isoform 6) | Ubiquitination | - | 40.08 | - | |
| 191 | Phosphorylation | IEQEQKFSIIRNGQL CCHHHCEEEEECCEE | 24.92 | 25599653 | |
| 216 | Phosphorylation | GDIAQVKYGDLLPAD CCHHHCCCCCEECCC | 19.60 | 27196784 | |
| 237 | Phosphorylation | NDLKIDESSLTGESD CCEEECHHHCCCCCH | 27.22 | 25850435 | |
| 238 | Phosphorylation | DLKIDESSLTGESDH CEEECHHHCCCCCHH | 28.09 | 25849741 | |
| 240 | Phosphorylation | KIDESSLTGESDHVK EECHHHCCCCCHHHH | 40.63 | 25850435 | |
| 249 | Phosphorylation | ESDHVKKSLDKDPML CCHHHHHHCCCCCCE | 35.76 | 23322592 | |
| 252 | Ubiquitination | HVKKSLDKDPMLLSG HHHHHCCCCCCEEEC | 69.86 | 21890473 | |
| 252 | Ubiquitination | HVKKSLDKDPMLLSG HHHHHCCCCCCEEEC | 69.86 | 21890473 | |
| 252 (in isoform 1) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 (in isoform 2) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 (in isoform 3) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 (in isoform 4) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 (in isoform 5) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 (in isoform 6) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 (in isoform 7) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 (in isoform 8) | Ubiquitination | - | 69.86 | 21890473 | |
| 252 | Ubiquitination | HVKKSLDKDPMLLSG HHHHHCCCCCCEEEC | 69.86 | 21890473 | |
| 272 | Phosphorylation | GSGRMVVTAVGVNSQ CCCCEEEEEEEECCC | 12.29 | - | |
| 302 (in isoform 3) | Ubiquitination | - | 51.29 | 21890473 | |
| 302 (in isoform 5) | Ubiquitination | - | 51.29 | 21890473 | |
| 302 (in isoform 7) | Ubiquitination | - | 51.29 | 21890473 | |
| 302 (in isoform 8) | Ubiquitination | - | 51.29 | 21890473 | |
| 314 | Ubiquitination | PENRNKAKTQDGVAL CCCCCCCCCCCCEEE | 48.61 | 21906983 | |
| 314 (in isoform 1) | Ubiquitination | - | 48.61 | 21890473 | |
| 314 (in isoform 2) | Ubiquitination | - | 48.61 | 21890473 | |
| 314 (in isoform 4) | Ubiquitination | - | 48.61 | 21890473 | |
| 314 (in isoform 6) | Ubiquitination | - | 48.61 | 21890473 | |
| 315 | Phosphorylation | ENRNKAKTQDGVALE CCCCCCCCCCCEEEE | 36.43 | 28111955 | |
| 325 (in isoform 3) | Ubiquitination | - | 38.89 | 21890473 | |
| 325 (in isoform 5) | Ubiquitination | - | 38.89 | 21890473 | |
| 325 (in isoform 7) | Ubiquitination | - | 38.89 | 21890473 | |
| 325 (in isoform 8) | Ubiquitination | - | 38.89 | 21890473 | |
| 328 | Phosphorylation | LEIQPLNSQEGIDNE EEEEECCCCCCCCCH | 36.97 | 30266825 | |
| 337 | Ubiquitination | EGIDNEEKDKKAVKV CCCCCHHHHHHCCCC | 69.53 | 21906983 | |
| 337 (in isoform 1) | Ubiquitination | - | 69.53 | 21890473 | |
| 337 (in isoform 2) | Ubiquitination | - | 69.53 | 21890473 | |
| 337 (in isoform 4) | Ubiquitination | - | 69.53 | 21890473 | |
| 337 (in isoform 6) | Ubiquitination | - | 69.53 | 21890473 | |
| 339 | Ubiquitination | IDNEEKDKKAVKVPK CCCHHHHHHCCCCCH | 54.41 | - | |
| 339 (in isoform 6) | Ubiquitination | - | 54.41 | - | |
| 340 | Ubiquitination | DNEEKDKKAVKVPKK CCHHHHHHCCCCCHH | 69.42 | - | |
| 340 (in isoform 6) | Ubiquitination | - | 69.42 | - | |
| 355 | Ubiquitination | EKSVLQGKLTRLAVQ HHHHHHHHHHHHHHH | 33.45 | - | |
| 355 (in isoform 6) | Ubiquitination | - | 33.45 | - | |
| 357 | Phosphorylation | SVLQGKLTRLAVQIG HHHHHHHHHHHHHHH | 27.42 | 23532336 | |
| 415 | Phosphorylation | KFFIIGITVLVVAVP HHHHHCEEEEEEECC | 11.54 | - | |
| 430 (in isoform 3) | Ubiquitination | - | 10.15 | 21890473 | |
| 430 (in isoform 5) | Ubiquitination | - | 10.15 | 21890473 | |
| 430 (in isoform 7) | Ubiquitination | - | 10.15 | 21890473 | |
| 430 (in isoform 8) | Ubiquitination | - | 10.15 | 21890473 | |
| 435 | Phosphorylation | AVTISLAYSVKKMMK HHHHHHHHHHHHHHC | 21.20 | - | |
| 436 | Phosphorylation | VTISLAYSVKKMMKD HHHHHHHHHHHHHCC | 23.12 | - | |
| 442 | Ubiquitination | YSVKKMMKDNNLVRH HHHHHHHCCCCHHHH | 54.53 | - | |
| 442 (in isoform 1) | Ubiquitination | - | 54.53 | 21890473 | |
| 442 (in isoform 2) | Ubiquitination | - | 54.53 | 21890473 | |
| 442 (in isoform 4) | Ubiquitination | - | 54.53 | 21890473 | |
| 442 (in isoform 6) | Ubiquitination | - | 54.53 | 21890473 | |
| 464 | Phosphorylation | GNATAICSDKTGTLT CCCEEEECCCCCCEE | 35.71 | - | |
| 466 | 2-Hydroxyisobutyrylation | ATAICSDKTGTLTMN CEEEECCCCCCEEEC | 32.34 | - | |
| 467 | Phosphorylation | TAICSDKTGTLTMNR EEEECCCCCCEEECC | 40.15 | - | |
| 469 | Phosphorylation | ICSDKTGTLTMNRMT EECCCCCCEEECCHH | 25.04 | - | |
| 471 | Phosphorylation | SDKTGTLTMNRMTVV CCCCCCEEECCHHHE | 16.55 | 27470641 | |
| 476 | Phosphorylation | TLTMNRMTVVQAYIG CEEECCHHHEEEEEC | 17.81 | 26434776 | |
| 481 | Phosphorylation | RMTVVQAYIGGIHYR CHHHEEEEECCCCCC | 5.30 | 26434776 | |
| 487 | Phosphorylation | AYIGGIHYRQIPSPD EEECCCCCCCCCCCC | 11.42 | 26434776 | |
| 509 | Phosphorylation | DLIVNGISINSAYTS HHHHCCCCCCCHHHC | 19.67 | 27251275 | |
| 511 (in isoform 3) | Ubiquitination | - | 17.50 | 21890473 | |
| 511 (in isoform 5) | Ubiquitination | - | 17.50 | 21890473 | |
| 511 (in isoform 7) | Ubiquitination | - | 17.50 | 21890473 | |
| 511 (in isoform 8) | Ubiquitination | - | 17.50 | 21890473 | |
| 512 | Phosphorylation | VNGISINSAYTSKIL HCCCCCCCHHHCCCC | 22.45 | 27251275 | |
| 514 | Phosphorylation | GISINSAYTSKILPP CCCCCCHHHCCCCCC | 16.03 | 27251275 | |
| 515 | Phosphorylation | ISINSAYTSKILPPE CCCCCHHHCCCCCCH | 24.22 | 27251275 | |
| 516 | Phosphorylation | SINSAYTSKILPPEK CCCCHHHCCCCCCHH | 12.67 | 27251275 | |
| 523 | Ubiquitination | SKILPPEKEGGLPRQ CCCCCCHHCCCCCCC | 68.39 | 21890473 | |
| 523 | Ubiquitination | SKILPPEKEGGLPRQ CCCCCCHHCCCCCCC | 68.39 | 21890473 | |
| 523 (in isoform 1) | Ubiquitination | - | 68.39 | 21890473 | |
| 523 (in isoform 2) | Ubiquitination | - | 68.39 | 21890473 | |
| 523 (in isoform 4) | Ubiquitination | - | 68.39 | 21890473 | |
| 523 (in isoform 6) | Ubiquitination | - | 68.39 | 21890473 | |
| 523 | Ubiquitination | SKILPPEKEGGLPRQ CCCCCCHHCCCCCCC | 68.39 | 21890473 | |
| 535 | Phosphorylation | PRQVGNKTECALLGF CCCCCCHHHHHHHHH | 40.05 | - | |
| 547 | Ubiquitination | LGFVTDLKQDYQAVR HHHHHCHHHHHHHHH | 43.89 | - | |
| 549 (in isoform 3) | Ubiquitination | - | 35.60 | 21890473 | |
| 549 (in isoform 5) | Ubiquitination | - | 35.60 | 21890473 | |
| 549 (in isoform 7) | Ubiquitination | - | 35.60 | 21890473 | |
| 549 (in isoform 8) | Ubiquitination | - | 35.60 | 21890473 | |
| 561 | Ubiquitination | RNEVPEEKLYKVYTF HCCCCHHHHHEEEEH | 56.29 | 21906983 | |
| 561 (in isoform 1) | Ubiquitination | - | 56.29 | 21890473 | |
| 561 (in isoform 2) | Ubiquitination | - | 56.29 | 21890473 | |
| 561 (in isoform 4) | Ubiquitination | - | 56.29 | 21890473 | |
| 561 (in isoform 6) | Ubiquitination | - | 56.29 | 21890473 | |
| 563 | Phosphorylation | EVPEEKLYKVYTFNS CCCHHHHHEEEEHHH | 14.96 | 26552605 | |
| 564 | Ubiquitination | VPEEKLYKVYTFNSV CCHHHHHEEEEHHHH | 38.92 | - | |
| 566 | Phosphorylation | EEKLYKVYTFNSVRK HHHHHEEEEHHHHHH | 11.06 | 26657352 | |
| 567 | Phosphorylation | EKLYKVYTFNSVRKS HHHHEEEEHHHHHHH | 21.23 | 25332170 | |
| 570 | Phosphorylation | YKVYTFNSVRKSMST HEEEEHHHHHHHHCE | 21.07 | 25159151 | |
| 572 | Dimethylation | VYTFNSVRKSMSTVI EEEHHHHHHHHCEEE | 25.75 | - | |
| 572 | Methylation | VYTFNSVRKSMSTVI EEEHHHHHHHHCEEE | 25.75 | 24376755 | |
| 574 | Phosphorylation | TFNSVRKSMSTVIRN EHHHHHHHHCEEEEC | 13.85 | 26657352 | |
| 576 | Phosphorylation | NSVRKSMSTVIRNPN HHHHHHHCEEEECCC | 26.98 | 24719451 | |
| 577 | Phosphorylation | SVRKSMSTVIRNPNG HHHHHHCEEEECCCC | 16.00 | 24719451 | |
| 590 | Phosphorylation | NGGFRMYSKGASEII CCCCEEECCCCHHHH | 18.44 | 24719451 | |
| 608 | Ubiquitination | CNRILDRKGEAVPFK HHHHHCCCCCCCCCC | 61.85 | - | |
| 686 | Ubiquitination | PDAIAKCKQAGITVR CHHHHHHHHCCCEEE | 42.34 | - | |
| 686 (in isoform 6) | Ubiquitination | - | 42.34 | - | |
| 691 | Phosphorylation | KCKQAGITVRMVTGD HHHHCCCEEEEECCC | 10.92 | - | |
| 709 | Ubiquitination | TARAIATKCGILTPG HHHHHHHHCCCCCCC | 22.80 | - | |
| 709 (in isoform 6) | Ubiquitination | - | 22.80 | - | |
| 723 (in isoform 3) | Ubiquitination | - | 68.19 | 21890473 | |
| 723 (in isoform 5) | Ubiquitination | - | 68.19 | 21890473 | |
| 723 (in isoform 7) | Ubiquitination | - | 68.19 | 21890473 | |
| 723 (in isoform 8) | Ubiquitination | - | 68.19 | 21890473 | |
| 725 | Ubiquitination | DFLCLEGKEFNRLIR CEEEECCHHHHHHHH | 50.16 | - | |
| 725 (in isoform 6) | Ubiquitination | - | 50.16 | - | |
| 733 (in isoform 3) | Ubiquitination | - | 48.62 | 21890473 | |
| 733 (in isoform 5) | Ubiquitination | - | 48.62 | 21890473 | |
| 733 (in isoform 7) | Ubiquitination | - | 48.62 | 21890473 | |
| 733 (in isoform 8) | Ubiquitination | - | 48.62 | 21890473 | |
| 735 | Ubiquitination | NRLIRNEKGEVEQEK HHHHHCCCCCCCHHH | 65.01 | 21906983 | |
| 735 (in isoform 1) | Ubiquitination | - | 65.01 | 21890473 | |
| 735 (in isoform 2) | Ubiquitination | - | 65.01 | 21890473 | |
| 735 (in isoform 4) | Ubiquitination | - | 65.01 | 21890473 | |
| 735 (in isoform 6) | Ubiquitination | - | 65.01 | 21890473 | |
| 742 | Ubiquitination | KGEVEQEKLDKIWPK CCCCCHHHHHHHHHH | 62.77 | - | |
| 745 | Ubiquitination | VEQEKLDKIWPKLRV CCHHHHHHHHHHHHH | 58.04 | 21890473 | |
| 745 | Malonylation | VEQEKLDKIWPKLRV CCHHHHHHHHHHHHH | 58.04 | 26320211 | |
| 745 | Ubiquitination | VEQEKLDKIWPKLRV CCHHHHHHHHHHHHH | 58.04 | 21890473 | |
| 745 (in isoform 1) | Ubiquitination | - | 58.04 | 21890473 | |
| 745 (in isoform 2) | Ubiquitination | - | 58.04 | 21890473 | |
| 745 (in isoform 4) | Ubiquitination | - | 58.04 | 21890473 | |
| 745 (in isoform 6) | Ubiquitination | - | 58.04 | 21890473 | |
| 745 | Ubiquitination | VEQEKLDKIWPKLRV CCHHHHHHHHHHHHH | 58.04 | 21890473 | |
| 756 | Phosphorylation | KLRVLARSSPTDKHT HHHHHHCCCCCCHHH | 34.75 | 29514088 | |
| 757 | Phosphorylation | LRVLARSSPTDKHTL HHHHHCCCCCCHHHH | 26.68 | 29514088 | |
| 759 | Phosphorylation | VLARSSPTDKHTLVK HHHCCCCCCHHHHHH | 60.68 | 29514088 | |
| 761 | 2-Hydroxyisobutyrylation | ARSSPTDKHTLVKGI HCCCCCCHHHHHHHH | 40.75 | - | |
| 763 | Phosphorylation | SSPTDKHTLVKGIID CCCCCHHHHHHHHHH | 38.70 | 23911959 | |
| 771 | Phosphorylation | LVKGIIDSTVGEHRQ HHHHHHHCCCCCCCC | 18.00 | 23401153 | |
| 772 | Phosphorylation | VKGIIDSTVGEHRQV HHHHHHCCCCCCCCE | 28.87 | 30576142 | |
| 782 (in isoform 3) | Ubiquitination | - | 4.09 | 21890473 | |
| 782 (in isoform 5) | Ubiquitination | - | 4.09 | 21890473 | |
| 782 (in isoform 7) | Ubiquitination | - | 4.09 | 21890473 | |
| 782 (in isoform 8) | Ubiquitination | - | 4.09 | 21890473 | |
| 783 | Phosphorylation | HRQVVAVTGDGTNDG CCCEEEEECCCCCCC | 21.59 | - | |
| 787 | Phosphorylation | VAVTGDGTNDGPALK EEEECCCCCCCHHHH | 34.57 | - | |
| 794 | Ubiquitination | TNDGPALKKADVGFA CCCCHHHHHCCCEEE | 48.28 | 21890473 | |
| 794 | 2-Hydroxyisobutyrylation | TNDGPALKKADVGFA CCCCHHHHHCCCEEE | 48.28 | - | |
| 794 | Ubiquitination | TNDGPALKKADVGFA CCCCHHHHHCCCEEE | 48.28 | 21890473 | |
| 794 (in isoform 1) | Ubiquitination | - | 48.28 | 21890473 | |
| 794 (in isoform 2) | Ubiquitination | - | 48.28 | 21890473 | |
| 794 (in isoform 4) | Ubiquitination | - | 48.28 | 21890473 | |
| 794 (in isoform 6) | Ubiquitination | - | 48.28 | 21890473 | |
| 794 | Ubiquitination | TNDGPALKKADVGFA CCCCHHHHHCCCEEE | 48.28 | 21890473 | |
| 897 (in isoform 3) | Ubiquitination | - | 45.20 | 21890473 | |
| 897 (in isoform 5) | Ubiquitination | - | 45.20 | 21890473 | |
| 897 (in isoform 7) | Ubiquitination | - | 45.20 | 21890473 | |
| 897 (in isoform 8) | Ubiquitination | - | 45.20 | 21890473 | |
| 898 | Phosphorylation | ATEPPTESLLKRRPY CCCCCCHHHHHCCCC | 41.29 | 24719451 | |
| 905 | Phosphorylation | SLLKRRPYGRNKPLI HHHHCCCCCCCCCCC | 27.23 | - | |
| 909 | Ubiquitination | RRPYGRNKPLISRTM CCCCCCCCCCCCHHH | 39.58 | - | |
| 909 (in isoform 1) | Ubiquitination | - | 39.58 | 21890473 | |
| 909 (in isoform 2) | Ubiquitination | - | 39.58 | 21890473 | |
| 909 (in isoform 4) | Ubiquitination | - | 39.58 | 21890473 | |
| 909 (in isoform 6) | Ubiquitination | - | 39.58 | 21890473 | |
| 987 (in isoform 5) | Phosphorylation | - | 6.30 | 27174698 | |
| 992 (in isoform 5) | Phosphorylation | - | 10.92 | 27174698 | |
| 999 (in isoform 4) | Phosphorylation | - | 12.43 | 27174698 | |
| 999 (in isoform 5) | Phosphorylation | - | 12.43 | 27174698 | |
| 1003 (in isoform 5) | Phosphorylation | - | 13.63 | 27174698 | |
| 1004 (in isoform 4) | Phosphorylation | - | 12.98 | 27174698 | |
| 1005 (in isoform 5) | Phosphorylation | - | 5.09 | 27174698 | |
| 1011 (in isoform 4) | Phosphorylation | - | 2.87 | 27174698 | |
| 1015 (in isoform 4) | Phosphorylation | - | 29.70 | 27174698 | |
| 1017 (in isoform 4) | Phosphorylation | - | 43.18 | 27174698 | |
| 1023 (in isoform 5) | Ubiquitination | - | 21.93 | 21890473 | |
| 1035 (in isoform 4) | Ubiquitination | - | 2.25 | 21890473 | |
| 1051 | O-linked_Glycosylation | QFISAIPTRSLKFLK HHHHHCCHHHHHHHH | 27.12 | 28510447 | |
| 1055 (in isoform 6) | Ubiquitination | - | 50.31 | - | |
| 1059 (in isoform 3) | Ubiquitination | - | 63.13 | 21890473 | |
| 1059 (in isoform 7) | Ubiquitination | - | 63.13 | 21890473 | |
| 1059 (in isoform 8) | Ubiquitination | - | 63.13 | 21890473 | |
| 1070 | Phosphorylation | GTTKEEITKDAEGLD CCCHHHHCCCCCCCC | 26.59 | 30622161 | |
| 1071 | Ubiquitination | TTKEEITKDAEGLDE CCHHHHCCCCCCCCC | 61.68 | 21906983 | |
| 1071 (in isoform 1) | Ubiquitination | - | 61.68 | 21890473 | |
| 1071 (in isoform 2) | Ubiquitination | - | 61.68 | 21890473 | |
| 1071 (in isoform 6) | Ubiquitination | - | 61.68 | 21890473 | |
| 1088 (in isoform 5) | Phosphorylation | - | 54.73 | 29978859 | |
| 1089 (in isoform 5) | Phosphorylation | - | 16.67 | 29978859 | |
| 1090 (in isoform 5) | Phosphorylation | - | 26.28 | 26657352 | |
| 1090 (in isoform 7) | Phosphorylation | - | 26.28 | - | |
| 1091 (in isoform 5) | Phosphorylation | - | 4.02 | 26657352 | |
| 1093 (in isoform 7) | Ubiquitination | - | 5.19 | 21890473 | |
| 1100 (in isoform 4) | Phosphorylation | - | 5.17 | 29978859 | |
| 1101 (in isoform 4) | Phosphorylation | - | 24.90 | 29978859 | |
| 1101 (in isoform 7) | Phosphorylation | - | 24.90 | 25056879 | |
| 1102 | Phosphorylation | RGLNRIQTQIDVINT HCCCCCHHHHHHHHH | 25.72 | 29083192 | |
| 1102 (in isoform 4) | Phosphorylation | - | 25.72 | 26657352 | |
| 1102 (in isoform 6) | Phosphorylation | - | 25.72 | - | |
| 1103 (in isoform 4) | Phosphorylation | - | 17.32 | 26657352 | |
| 1103 (in isoform 5) | Phosphorylation | - | 17.32 | - | |
| 1104 (in isoform 5) | Phosphorylation | - | 5.33 | - | |
| 1105 (in isoform 6) | Ubiquitination | - | 25.98 | 21890473 | |
| 1108 (in isoform 6) | Ubiquitination | - | 34.39 | - | |
| 1108 (in isoform 7) | Ubiquitination | - | 34.39 | 21890473 | |
| 1109 | Phosphorylation | TQIDVINTFQTGASF HHHHHHHHHCCCCCH | 13.14 | 29083192 | |
| 1112 | Phosphorylation | DVINTFQTGASFKGV HHHHHHCCCCCHHHH | 30.44 | 29083192 | |
| 1113 (in isoform 6) | Phosphorylation | - | 14.40 | 25056879 | |
| 1115 | Phosphorylation | NTFQTGASFKGVLRR HHHCCCCCHHHHHHH | 28.92 | 29083192 | |
| 1115 (in isoform 4) | Phosphorylation | - | 28.92 | - | |
| 1116 (in isoform 4) | Phosphorylation | - | 8.72 | - | |
| 1117 (in isoform 5) | Phosphorylation | - | 45.69 | - | |
| 1120 (in isoform 5) | Phosphorylation | - | 5.21 | - | |
| 1120 (in isoform 6) | Ubiquitination | - | 5.21 | 21890473 | |
| 1120 (in isoform 8) | Ubiquitination | - | 5.21 | 21890473 | |
| 1120 | Ubiquitination | GASFKGVLRRQNMGQ CCCHHHHHHHCCCCC | 5.21 | 21890473 | |
| 1124 (in isoform 3) | Phosphorylation | - | 34.44 | 29978859 | |
| 1125 (in isoform 3) | Phosphorylation | - | 4.07 | 29978859 | |
| 1126 (in isoform 3) | Phosphorylation | - | 21.21 | 26657352 | |
| 1127 (in isoform 3) | Phosphorylation | - | 24.17 | 26657352 | |
| 1129 (in isoform 4) | Phosphorylation | - | 6.60 | - | |
| 1132 | Phosphorylation | MGQHLDVKLVPSSSY CCCCCEEEEECCHHH | 43.35 | 17081983 | |
| 1132 | Ubiquitination | MGQHLDVKLVPSSSY CCCCCEEEEECCHHH | 43.35 | 21906983 | |
| 1132 (in isoform 1) | Ubiquitination | - | 43.35 | 21890473 | |
| 1132 (in isoform 4) | Phosphorylation | - | 43.35 | - | |
| 1136 (in isoform 2) | Phosphorylation | - | 25.16 | 29978859 | |
| 1137 (in isoform 2) | Phosphorylation | - | 22.53 | 29978859 | |
| 1138 (in isoform 2) | Phosphorylation | - | 34.90 | 26657352 | |
| 1139 (in isoform 2) | Phosphorylation | - | 13.50 | 26657352 | |
| 1139 (in isoform 3) | Phosphorylation | - | 13.50 | - | |
| 1140 (in isoform 3) | Phosphorylation | - | 2.70 | - | |
| 1144 | Ubiquitination | SSYIKVVKAFHSSLH HHHHHHHHHHHHHHH | 48.61 | - | |
| 1144 (in isoform 8) | Ubiquitination | - | 48.61 | 21890473 | |
| 1146 (in isoform 7) | Ubiquitination | - | 4.81 | 21890473 | |
| 1148 | Phosphorylation | KVVKAFHSSLHESIQ HHHHHHHHHHHHHCC | 28.30 | 28857561 | |
| 1149 | Phosphorylation | VVKAFHSSLHESIQK HHHHHHHHHHHHCCC | 25.77 | 26307563 | |
| 1151 (in isoform 2) | Phosphorylation | - | 28.80 | - | |
| 1152 (in isoform 2) | Phosphorylation | - | 55.63 | - | |
| 1153 | Phosphorylation | FHSSLHESIQKPYNQ HHHHHHHHCCCCCCC | 21.41 | 26074081 | |
| 1153 (in isoform 3) | Phosphorylation | - | 21.41 | - | |
| 1156 | Ubiquitination | SLHESIQKPYNQKSI HHHHHCCCCCCCCCH | 48.04 | 21890473 | |
| 1156 (in isoform 1) | Ubiquitination | - | 48.04 | 21890473 | |
| 1156 (in isoform 3) | Phosphorylation | - | 48.04 | - | |
| 1158 | Phosphorylation | HESIQKPYNQKSIHS HHHCCCCCCCCCHHH | 36.94 | 26074081 | |
| 1158 (in isoform 6) | Ubiquitination | - | 36.94 | 21890473 | |
| 1161 (in isoform 6) | Ubiquitination | - | 47.98 | - | |
| 1162 | Phosphorylation | QKPYNQKSIHSFMTH CCCCCCCCHHHHHCC | 18.77 | 22617229 | |
| 1165 | Phosphorylation | YNQKSIHSFMTHPEF CCCCCHHHHHCCHHH | 18.29 | 21712546 | |
| 1165 (in isoform 2) | Phosphorylation | - | 18.29 | - | |
| 1168 | Phosphorylation | KSIHSFMTHPEFAIE CCHHHHHCCHHHHHC | 32.06 | 21712546 | |
| 1168 (in isoform 2) | Phosphorylation | - | 32.06 | - | |
| 1176 | Phosphorylation | HPEFAIEEELPRTPL CHHHHHCCCCCCCCC | 59.74 | 12540962 | |
| 1181 | Phosphorylation | IEEELPRTPLLDEEE HCCCCCCCCCCCHHH | 19.15 | 27273156 | |
| 1182 (in isoform 8) | Ubiquitination | - | 32.00 | 21890473 | |
| 1194 | Ubiquitination | EEEENPDKASKFGTR HHHHCCCHHHHCCCE | 56.68 | 2190698 | |
| 1194 (in isoform 1) | Ubiquitination | - | 56.68 | 21890473 | |
| 1196 | Phosphorylation | EENPDKASKFGTRVL HHCCCHHHHCCCEEE | 33.97 | 29083192 | |
| 1197 | Ubiquitination | ENPDKASKFGTRVLL HCCCHHHHCCCEEEE | 53.31 | - | |
| 1203 | Phosphorylation | SKFGTRVLLLDGEVT HHCCCEEEEECCEEE | 3.37 | 20068231 | |
| 1210 | Phosphorylation | LLLDGEVTPYANTNN EEECCEEECCCCCCC | 13.28 | 20068231 | |
| 1212 | Phosphorylation | LDGEVTPYANTNNNA ECCEEECCCCCCCCC | 11.78 | 12540962 | |
| 1215 | Phosphorylation | EVTPYANTNNNAVDC EEECCCCCCCCCCCC | 31.02 | 20068231 | |
| 1230 | Phosphorylation | NQVQLPQSDSSLQSL CCCCCCCCCHHHHHH | 37.20 | 20068231 | |
| 1232 | Phosphorylation | VQLPQSDSSLQSLET CCCCCCCHHHHHHHH | 37.89 | 20068231 | |
| 1233 | Phosphorylation | QLPQSDSSLQSLETS CCCCCCHHHHHHHHC | 35.10 | 20068231 | |
| 1236 | Phosphorylation | QSDSSLQSLETSV-- CCCHHHHHHHHCC-- | 33.20 | 20068231 | |
| 1239 | Phosphorylation | SSLQSLETSV----- HHHHHHHHCC----- | 39.83 | 20068231 | |
| 1240 | Phosphorylation | SLQSLETSV------ HHHHHHHCC------ | 19.22 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 1102 | T | Phosphorylation | Kinase | PKC | - | Uniprot |
| 1115 | S | Phosphorylation | Kinase | PRKCA | P05696 | GPS |
| 1176 | Y | Phosphorylation | Kinase | PTK2 | Q05397 | GPS |
| 1212 | Y | Phosphorylation | Kinase | SRC-FAMILY | - | GPS |
| 1212 | Y | Phosphorylation | Kinase | SRC_GROUP | - | PhosphoELM |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AT2B4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AT2B4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DLG1_HUMAN | DLG1 | physical | 12511555 | |
| CSKP_HUMAN | CASK | physical | 12511555 | |
| DLG4_RAT | Dlg4 | physical | 11274188 | |
| DLG1_RAT | Dlg1 | physical | 11274188 | |
| DLG2_RAT | Dlg2 | physical | 11274188 | |
| DLG2_HUMAN | DLG2 | physical | 11274188 | |
| DLG3_HUMAN | DLG3 | physical | 11274188 | |
| AT1A1_HUMAN | ATP1A1 | physical | 26344197 | |
| ATP5J_HUMAN | ATP5J | physical | 26344197 | |
| CALX_HUMAN | CANX | physical | 26344197 | |
| CLGN_HUMAN | CLGN | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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