dbPTM

PSMD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSMD1_HUMAN
UniProt AC	Q99460
Protein Name	26S proteasome non-ATPase regulatory subunit 1
Gene Name	PSMD1
Organism	Homo sapiens (Human).
Sequence Length	953
Subcellular Localization
Protein Description	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
Protein Sequence	MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MITSAAGI -------CCCCHHHH	7.32	22223895
20	Ubiquitination	DEDEPQLKEFALHKL CCCCHHHHHHHHHHH	45.60	21906983
20 (in isoform 1)	Ubiquitination	-	45.60	21890473
20 (in isoform 2)	Ubiquitination	-	45.60	21890473
26	Ubiquitination	LKEFALHKLNAVVND HHHHHHHHHHHHHHH	44.26	23503661
49	Phosphorylation	VDKIEVLYEDEGFRS CCEEEEEECCCCCCH	26.89	16097034
110	Acetylation	KCIDHYTKQCVENAD HHHHHHHHHHHHCCC	34.24	26051181
110	Ubiquitination	KCIDHYTKQCVENAD HHHHHHHHHHHHCCC	34.24	21963094
110 (in isoform 2)	Ubiquitination	-	34.24	-
123	Ubiquitination	ADLPEGEKKPIDQRL CCCCCCCCCCHHHHH	74.77	22817900
124	Ubiquitination	DLPEGEKKPIDQRLE CCCCCCCCCHHHHHH	42.79	21906983
124 (in isoform 1)	Ubiquitination	-	42.79	21890473
124 (in isoform 2)	Ubiquitination	-	42.79	21890473
136	Acetylation	RLEGIVNKMFQRCLD HHHHHHHHHHHHHHC	30.14	25953088
136	Ubiquitination	RLEGIVNKMFQRCLD HHHHHHHHHHHHHHC	30.14	23000965
136 (in isoform 1)	Ubiquitination	-	30.14	21890473
136 (in isoform 2)	Ubiquitination	-	30.14	21890473
146	Acetylation	QRCLDDHKYKQAIGI HHHHCCHHHHHHHHH	62.22	25953088
146	Ubiquitination	QRCLDDHKYKQAIGI HHHHCCHHHHHHHHH	62.22	29967540
147	Phosphorylation	RCLDDHKYKQAIGIA HHHCCHHHHHHHHHH	12.62	-
148	2-Hydroxyisobutyrylation	CLDDHKYKQAIGIAL HHCCHHHHHHHHHHH	37.75	-
157	Phosphorylation	AIGIALETRRLDVFE HHHHHHHHHCCCCHH	23.18	20068231
166	Phosphorylation	RLDVFEKTILESNDV CCCCHHHHHHHCCCC	24.48	20068231
170	Phosphorylation	FEKTILESNDVPGML HHHHHHHCCCCCHHH	34.58	20068231
179	Phosphorylation	DVPGMLAYSLKLCMS CCCHHHHHHHHHHHH	15.58	20068231
180	Phosphorylation	VPGMLAYSLKLCMSL CCHHHHHHHHHHHHH	17.27	24719451
191	Ubiquitination	CMSLMQNKQFRNKVL HHHHHCCHHHHHHHH	33.64	23000965
196	Ubiquitination	QNKQFRNKVLRVLVK CCHHHHHHHHHHHHH	38.09	23000965
199	Dimethylation	QFRNKVLRVLVKIYM HHHHHHHHHHHHHHH	23.78	-
199	Methylation	QFRNKVLRVLVKIYM HHHHHHHHHHHHHHH	23.78	30762955
205	Phosphorylation	LRVLVKIYMNLEKPD HHHHHHHHHCCCCCC	3.68	27067055
210	Ubiquitination	KIYMNLEKPDFINVC HHHHCCCCCCCEEEE	53.72	16196087
235	Ubiquitination	AVSDILEKLVKEDNL HHHHHHHHHHHHCCH	55.95	16196087
270	Phosphorylation	SVIQNLRTVGTPIAS HHHHHHHCCCCCCCC	26.84	29255136
273	Phosphorylation	QNLRTVGTPIASVPG HHHHCCCCCCCCCCC	13.74	19664994
277	Phosphorylation	TVGTPIASVPGSTNT CCCCCCCCCCCCCCC	29.57	30266825
281	Phosphorylation	PIASVPGSTNTGTVP CCCCCCCCCCCCCCC	16.65	30266825
282	Phosphorylation	IASVPGSTNTGTVPG CCCCCCCCCCCCCCC	42.59	30266825
284	Phosphorylation	SVPGSTNTGTVPGSE CCCCCCCCCCCCCCC	34.03	30266825
286	Phosphorylation	PGSTNTGTVPGSEKD CCCCCCCCCCCCCCC	22.84	23927012
290	Phosphorylation	NTGTVPGSEKDSDSM CCCCCCCCCCCCCCC	35.09	30278072
292	Acetylation	GTVPGSEKDSDSMET CCCCCCCCCCCCCCC	65.32	23236377
292	Ubiquitination	GTVPGSEKDSDSMET CCCCCCCCCCCCCCC	65.32	21906983
292 (in isoform 1)	Ubiquitination	-	65.32	21890473
292 (in isoform 2)	Ubiquitination	-	65.32	21890473
294	Phosphorylation	VPGSEKDSDSMETEE CCCCCCCCCCCCCCC	42.53	29255136
296	Phosphorylation	GSEKDSDSMETEEKT CCCCCCCCCCCCCHH	23.59	29255136
297	Sulfoxidation	SEKDSDSMETEEKTS CCCCCCCCCCCCHHH	9.91	30846556
299	Phosphorylation	KDSDSMETEEKTSSA CCCCCCCCCCHHHHH	40.58	29255136
302	Ubiquitination	DSMETEEKTSSAFVG CCCCCCCHHHHHCCC	47.69	27667366
302 (in isoform 1)	Ubiquitination	-	47.69	21890473
302 (in isoform 2)	Ubiquitination	-	47.69	21890473
303	Phosphorylation	SMETEEKTSSAFVGK CCCCCCHHHHHCCCC	31.06	30266825
304	Phosphorylation	METEEKTSSAFVGKT CCCCCHHHHHCCCCC	30.64	30266825
305	Phosphorylation	ETEEKTSSAFVGKTP CCCCHHHHHCCCCCC	30.84	30266825
310	Acetylation	TSSAFVGKTPEASPE HHHHCCCCCCCCCCC	56.45	19608861
310	Malonylation	TSSAFVGKTPEASPE HHHHCCCCCCCCCCC	56.45	26320211
310	Sumoylation	TSSAFVGKTPEASPE HHHHCCCCCCCCCCC	56.45	19608861
310	Ubiquitination	TSSAFVGKTPEASPE HHHHCCCCCCCCCCC	56.45	27667366
310 (in isoform 1)	Ubiquitination	-	56.45	21890473
310 (in isoform 2)	Ubiquitination	-	56.45	21890473
311	Phosphorylation	SSAFVGKTPEASPEP HHHCCCCCCCCCCCC	22.04	19664994
315	Phosphorylation	VGKTPEASPEPKDQT CCCCCCCCCCCCHHH	28.30	19664994
319	Ubiquitination	PEASPEPKDQTLKMI CCCCCCCCHHHHHHH	61.89	21906983
319 (in isoform 1)	Ubiquitination	-	61.89	21890473
319 (in isoform 2)	Ubiquitination	-	61.89	21890473
322	Phosphorylation	SPEPKDQTLKMIKIL CCCCCHHHHHHHHHH	38.18	23403867
324	Ubiquitination	EPKDQTLKMIKILSG CCCHHHHHHHHHHCC	41.80	21906983
324 (in isoform 1)	Ubiquitination	-	41.80	21890473
324 (in isoform 2)	Ubiquitination	-	41.80	21890473
327	Ubiquitination	DQTLKMIKILSGEMA HHHHHHHHHHCCHHH	33.81	22817900
348	Phosphorylation	FLIRNNNTDLMILKN HHHHCCCCCEEEEEC	32.41	-
351	Sulfoxidation	RNNNTDLMILKNTKD HCCCCCEEEEECHHH	3.62	21406390
354	Acetylation	NTDLMILKNTKDAVR CCCEEEEECHHHHHH	52.20	27452117
354	Ubiquitination	NTDLMILKNTKDAVR CCCEEEEECHHHHHH	52.20	21906983
354 (in isoform 1)	Ubiquitination	-	52.20	21890473
354 (in isoform 2)	Ubiquitination	-	52.20	21890473
357	Ubiquitination	LMILKNTKDAVRNSV EEEEECHHHHHHHCH	53.75	22817900
363	Phosphorylation	TKDAVRNSVCHTATV HHHHHHHCHHHHHHH	18.63	28348404
367	Phosphorylation	VRNSVCHTATVIANS HHHCHHHHHHHHHHC	20.92	27251275
401	Acetylation	ARATNWAKFTATASL HHHCCHHHHHHEEEE	34.56	7467763
407	Phosphorylation	AKFTATASLGVIHKG HHHHHEEEEEEEECC	22.69	20068231
413	Acetylation	ASLGVIHKGHEKEAL EEEEEEECCCHHHHH	51.33	7467775
413	Ubiquitination	ASLGVIHKGHEKEAL EEEEEEECCCHHHHH	51.33	16196087
417	Acetylation	VIHKGHEKEALQLMA EEECCCHHHHHHHHH	42.48	7467787
417	Ubiquitination	VIHKGHEKEALQLMA EEECCCHHHHHHHHH	42.48	29967540
425	Phosphorylation	EALQLMATYLPKDTS HHHHHHHHHCCCCCC	16.18	28851738
426	Phosphorylation	ALQLMATYLPKDTSP HHHHHHHHCCCCCCC	16.09	28851738
429	Ubiquitination	LMATYLPKDTSPGSA HHHHHCCCCCCCCCC	71.67	16196087
488	Phosphorylation	LGLAAMGTARQDVYD HHHHHHHHHHHHHHH	12.94	22817900
494	Phosphorylation	GTARQDVYDLLKTNL HHHHHHHHHHHHCCC	14.79	-
498	Ubiquitination	QDVYDLLKTNLYQDD HHHHHHHHCCCCCCC	42.54	16196087
524	Ubiquitination	GLVMLGSKNAQAIED HHHHHCCCCHHHHHH	55.28	16196087
543	2-Hydroxyisobutyrylation	AQETQHEKILRGLAV HHHHHHHHHHHHHHH	44.94	-
543	Acetylation	AQETQHEKILRGLAV HHHHHHHHHHHHHHH	44.94	25953088
543	Ubiquitination	AQETQHEKILRGLAV HHHHHHHHHHHHHHH	44.94	21906983
543 (in isoform 1)	Ubiquitination	-	44.94	21890473
543 (in isoform 2)	Ubiquitination	-	44.94	21890473
560	Sulfoxidation	ALVMYGRMEEADALI HHHHHCCHHHHHHHH	4.79	21406390
571	Glutathionylation	DALIESLCRDKDPIL HHHHHHHCCCCCHHH	8.02	22555962
574	2-Hydroxyisobutyrylation	IESLCRDKDPILRRS HHHHCCCCCHHHHHC	46.16	-
574	Acetylation	IESLCRDKDPILRRS HHHHCCCCCHHHHHC	46.16	25953088
574	Ubiquitination	IESLCRDKDPILRRS HHHHCCCCCHHHHHC	46.16	24816145
597	Ubiquitination	YCGSGNNKAIRRLLH ECCCCCHHHHHHHHH	49.55	21963094
608	Phosphorylation	RLLHVAVSDVNDDVR HHHHHHHHCCCHHHH	26.55	-
633	Glutathionylation	LFRTPEQCPSVVSLL EECCHHHCCCHHHHH	2.30	22555962
633	S-palmitoylation	LFRTPEQCPSVVSLL EECCHHHCCCHHHHH	2.30	29575903
641	Phosphorylation	PSVVSLLSESYNPHV CCHHHHHCCCCCCCC	29.77	28152594
643	Phosphorylation	VVSLLSESYNPHVRY HHHHHCCCCCCCCCH	27.17	28152594
644	Phosphorylation	VSLLSESYNPHVRYG HHHHCCCCCCCCCHH	28.76	28152594
666	Ubiquitination	CCAGTGNKEAINLLE HCCCCCCHHHHHHHH	50.28	16196087
675	Sulfoxidation	AINLLEPMTNDPVNY HHHHHHCCCCCCCHH	3.90	30846556
713	Phosphorylation	VNQFRQLYSKVINDK HHHHHHHHHHHHCCC	9.71	22461510
715	Ubiquitination	QFRQLYSKVINDKHD HHHHHHHHHHCCCHH	33.31	32015554
720	Acetylation	YSKVINDKHDDVMAK HHHHHCCCHHHHHHH	44.43	25825284
720	Ubiquitination	YSKVINDKHDDVMAK HHHHHCCCHHHHHHH	44.43	21906983
720 (in isoform 1)	Ubiquitination	-	44.43	21890473
720 (in isoform 2)	Ubiquitination	-	44.43	21890473
725	Sulfoxidation	NDKHDDVMAKFGAIL CCCHHHHHHHHHHHH	4.28	30846556
727	Ubiquitination	KHDDVMAKFGAILAQ CHHHHHHHHHHHHHC	26.66	16196087
796	Ubiquitination	IGLNKDLKMPKVQYK EECCCCCCCCCCCCC	64.39	27667366
799	Ubiquitination	NKDLKMPKVQYKSNC CCCCCCCCCCCCCCC	38.17	29967540
803	Acetylation	KMPKVQYKSNCKPST CCCCCCCCCCCCCCC	20.36	25953088
803	Ubiquitination	KMPKVQYKSNCKPST CCCCCCCCCCCCCCC	20.36	33845483
806	Glutathionylation	KVQYKSNCKPSTFAY CCCCCCCCCCCCCCC	9.89	22555962
806	S-palmitoylation	KVQYKSNCKPSTFAY CCCCCCCCCCCCCCC	9.89	29575903
807	Acetylation	VQYKSNCKPSTFAYP CCCCCCCCCCCCCCC	46.37	26051181
807	Ubiquitination	VQYKSNCKPSTFAYP CCCCCCCCCCCCCCC	46.37	27667366
807 (in isoform 2)	Ubiquitination	-	46.37	21890473
809	Phosphorylation	YKSNCKPSTFAYPAP CCCCCCCCCCCCCCC	22.96	28152594
809	Ubiquitination	YKSNCKPSTFAYPAP CCCCCCCCCCCCCCC	22.96	22817900
810	Phosphorylation	KSNCKPSTFAYPAPL CCCCCCCCCCCCCCC	22.32	28152594
810	Ubiquitination	KSNCKPSTFAYPAPL CCCCCCCCCCCCCCC	22.32	22817900
811	Ubiquitination	SNCKPSTFAYPAPLE CCCCCCCCCCCCCCC	7.81	22817900
813	Phosphorylation	CKPSTFAYPAPLEVP CCCCCCCCCCCCCCC	8.85	28152594
813	Ubiquitination	CKPSTFAYPAPLEVP CCCCCCCCCCCCCCC	8.85	23503661
817	Ubiquitination	TFAYPAPLEVPKEKE CCCCCCCCCCCCHHH	12.92	22817900
818	Ubiquitination	FAYPAPLEVPKEKEK CCCCCCCCCCCHHHH	56.57	33845483
821	Acetylation	PAPLEVPKEKEKEKV CCCCCCCCHHHHHCC	83.22	26051181
821	Ubiquitination	PAPLEVPKEKEKEKV CCCCCCCCHHHHHCC	83.22	21890473
821 (in isoform 1)	Ubiquitination	-	83.22	21890473
822	Ubiquitination	APLEVPKEKEKEKVS CCCCCCCHHHHHCCH	61.45	33845483
822 (in isoform 2)	Ubiquitination	-	61.45	21890473
823	Ubiquitination	PLEVPKEKEKEKVST CCCCCCHHHHHCCHH	79.00	22817900
825	Ubiquitination	EVPKEKEKEKVSTAV CCCCHHHHHCCHHHH	74.11	22817900
827	2-Hydroxyisobutyrylation	PKEKEKEKVSTAVLS CCHHHHHCCHHHHHH	53.18	-
827	Ubiquitination	PKEKEKEKVSTAVLS CCHHHHHCCHHHHHH	53.18	21906983
827 (in isoform 1)	Ubiquitination	-	53.18	21890473
829	Phosphorylation	EKEKEKVSTAVLSIT HHHHHCCHHHHHHHH	23.01	20068231
830	Phosphorylation	KEKEKVSTAVLSITA HHHHCCHHHHHHHHH	24.63	25159151
830	Ubiquitination	KEKEKVSTAVLSITA HHHHCCHHHHHHHHH	24.63	27667366
830 (in isoform 2)	Ubiquitination	-	24.63	21890473
831	Ubiquitination	EKEKVSTAVLSITAK HHHCCHHHHHHHHHH	7.86	22817900
831 (in isoform 2)	Ubiquitination	-	7.86	21890473
834	Phosphorylation	KVSTAVLSITAKAKK CCHHHHHHHHHHHHH	15.99	23879269
834	Ubiquitination	KVSTAVLSITAKAKK CCHHHHHHHHHHHHH	15.99	22817900
834 (in isoform 2)	Ubiquitination	-	15.99	21890473
836	Phosphorylation	STAVLSITAKAKKKE HHHHHHHHHHHHHHH	20.80	20068231
836	Ubiquitination	STAVLSITAKAKKKE HHHHHHHHHHHHHHH	20.80	22817900
837	Ubiquitination	TAVLSITAKAKKKEK HHHHHHHHHHHHHHH	14.24	22817900
838	Acetylation	AVLSITAKAKKKEKE HHHHHHHHHHHHHHH	52.68	25953088
838	Ubiquitination	AVLSITAKAKKKEKE HHHHHHHHHHHHHHH	52.68	21906983
838 (in isoform 1)	Ubiquitination	-	52.68	21890473
838 (in isoform 2)	Ubiquitination	-	52.68	21890473
840	Ubiquitination	LSITAKAKKKEKEKE HHHHHHHHHHHHHHH	64.77	22817900
841	Ubiquitination	SITAKAKKKEKEKEK HHHHHHHHHHHHHHH	71.65	22817900
842	Ubiquitination	ITAKAKKKEKEKEKK HHHHHHHHHHHHHHH	73.62	22817900
844	Ubiquitination	AKAKKKEKEKEKKEE HHHHHHHHHHHHHHH	80.91	23503661
848	Ubiquitination	KKEKEKEKKEEEKME HHHHHHHHHHHHHHH	76.25	22817900
849	Acetylation	KEKEKEKKEEEKMEV HHHHHHHHHHHHHHH	72.02	7851319
849	Ubiquitination	KEKEKEKKEEEKMEV HHHHHHHHHHHHHHH	72.02	33845483
853	Ubiquitination	KEKKEEEKMEVDEAE HHHHHHHHHHHHHHH	43.57	21906983
853 (in isoform 1)	Ubiquitination	-	43.57	21890473
859	Ubiquitination	EKMEVDEAEKKEEKE HHHHHHHHHHHHHHH	29.46	23000965
859 (in isoform 2)	Ubiquitination	-	29.46	21890473
861	Ubiquitination	MEVDEAEKKEEKEKK HHHHHHHHHHHHHHH	72.96	21906983
861 (in isoform 1)	Ubiquitination	-	72.96	21890473
862	Ubiquitination	EVDEAEKKEEKEKKK HHHHHHHHHHHHHHC	63.71	21906983
862 (in isoform 1)	Ubiquitination	-	63.71	21890473
865	Ubiquitination	EAEKKEEKEKKKEPE HHHHHHHHHHHCCCC	75.76	22817900
865 (in isoform 1)	Ubiquitination	-	75.76	21890473
867	Ubiquitination	EKKEEKEKKKEPEPN HHHHHHHHHCCCCCC	79.00	22817900
868	Ubiquitination	KKEEKEKKKEPEPNF HHHHHHHHCCCCCCC	64.56	27667366
869	Ubiquitination	KEEKEKKKEPEPNFQ HHHHHHHCCCCCCCC	84.94	21906983
869 (in isoform 1)	Ubiquitination	-	84.94	21890473
873	Ubiquitination	EKKKEPEPNFQLLDN HHHCCCCCCCCCCCC	58.62	33845483
884	Ubiquitination	LLDNPARVMPAQLKV CCCCHHHCCHHHCEE	6.14	33845483
890	Ubiquitination	RVMPAQLKVLTMPET HCCHHHCEEECCCCC	24.10	23000965
890 (in isoform 1)	Ubiquitination	-	24.10	21890473
898	Glutathionylation	VLTMPETCRYQPFKP EECCCCCCCCCCCCC	3.48	22555962
900	Phosphorylation	TMPETCRYQPFKPLS CCCCCCCCCCCCCCE	23.76	-
903	Ubiquitination	ETCRYQPFKPLSIGG CCCCCCCCCCCEEEE	8.21	22817900
903 (in isoform 2)	Ubiquitination	-	8.21	21890473
904	Ubiquitination	TCRYQPFKPLSIGGI CCCCCCCCCCEEEEE	52.29	33845483
915	Ubiquitination	IGGIIILKDTSEDIE EEEEEEEECCCHHHH	48.85	33845483
934	Sumoylation	PVAAHGPKIEEEEQE HHHHHCCCCCHHCCC	68.30	-
934	Ubiquitination	PVAAHGPKIEEEEQE HHHHHCCCCCHHCCC	68.30	22817900
934 (in isoform 1)	Ubiquitination	-	68.30	21890473
950	Phosphorylation	EPPEPFEYIDD---- CCCCCCCCCCC----	15.27	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
273	T	Phosphorylation	Kinase	MAPK14	P47811	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSMD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSMD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS8_HUMAN	PSMC5	physical	11361004
ADRM1_HUMAN	ADRM1	physical	16990800
PRS4_HUMAN	PSMC1	physical	19589775
PSMD5_HUMAN	PSMD5	physical	19589775
PRS7_HUMAN	PSMC2	physical	19589775
PSMD6_HUMAN	PSMD6	physical	22939629
PSMD2_HUMAN	PSMD2	physical	22939629
PSMD3_HUMAN	PSMD3	physical	22939629
PSMD4_HUMAN	PSMD4	physical	22939629
PSMD8_HUMAN	PSMD8	physical	22939629
PSMD5_HUMAN	PSMD5	physical	22939629
PSME1_HUMAN	PSME1	physical	22939629
PSME2_HUMAN	PSME2	physical	22939629
PSME3_HUMAN	PSME3	physical	22939629
RD23B_HUMAN	RAD23B	physical	22939629
TBA4A_HUMAN	TUBA4A	physical	22939629
ECD_HUMAN	ECD	physical	22939629
SF3A1_HUMAN	SF3A1	physical	22939629
SC24A_HUMAN	SEC24A	physical	22939629
PYR1_HUMAN	CAD	physical	22939629
TBA1B_HUMAN	TUBA1B	physical	22939629
RBM12_HUMAN	RBM12	physical	22939629
SC24C_HUMAN	SEC24C	physical	22939629
TPM4_HUMAN	TPM4	physical	22939629
TBA1A_HUMAN	TUBA1A	physical	22939629
ADRM1_HUMAN	ADRM1	physical	22863883
LIPA1_HUMAN	PPFIA1	physical	22863883
PRS4_HUMAN	PSMC1	physical	22863883
PRS7_HUMAN	PSMC2	physical	22863883
PRS6B_HUMAN	PSMC4	physical	22863883
PRS8_HUMAN	PSMC5	physical	22863883
PRS10_HUMAN	PSMC6	physical	22863883
PSD11_HUMAN	PSMD11	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
PSMD4_HUMAN	PSMD4	physical	22863883
PSMD6_HUMAN	PSMD6	physical	22863883
PSMD7_HUMAN	PSMD7	physical	22863883
RS15A_HUMAN	RPS15A	physical	22863883
RS28_HUMAN	RPS28	physical	22863883
RS8_HUMAN	RPS8	physical	22863883
UBC_HUMAN	UBC	physical	24743594
ADRM1_MOUSE	Adrm1	physical	25666615
ADRM1_HUMAN	ADRM1	physical	26344197
PSA1_HUMAN	PSMA1	physical	26344197
PSA2_HUMAN	PSMA2	physical	26344197
PSA3_HUMAN	PSMA3	physical	26344197
PSA4_HUMAN	PSMA4	physical	26344197
PSA5_HUMAN	PSMA5	physical	26344197
PSA7_HUMAN	PSMA7	physical	26344197
PSA7L_HUMAN	PSMA8	physical	26344197
PSB2_HUMAN	PSMB2	physical	26344197
PSB3_HUMAN	PSMB3	physical	26344197
PSB4_HUMAN	PSMB4	physical	26344197
PSB5_HUMAN	PSMB5	physical	26344197
PSB6_HUMAN	PSMB6	physical	26344197
PSB7_HUMAN	PSMB7	physical	26344197
PSB8_HUMAN	PSMB8	physical	26344197
PRS4_HUMAN	PSMC1	physical	26344197
PRS7_HUMAN	PSMC2	physical	26344197
PRS6A_HUMAN	PSMC3	physical	26344197
PRS6B_HUMAN	PSMC4	physical	26344197
PRS8_HUMAN	PSMC5	physical	26344197
PRS10_HUMAN	PSMC6	physical	26344197
PSD11_HUMAN	PSMD11	physical	26344197
PSD12_HUMAN	PSMD12	physical	26344197
PSD13_HUMAN	PSMD13	physical	26344197
PSDE_HUMAN	PSMD14	physical	26344197
PSMD2_HUMAN	PSMD2	physical	26344197
PSMD3_HUMAN	PSMD3	physical	26344197
PSMD6_HUMAN	PSMD6	physical	26344197
PSMD7_HUMAN	PSMD7	physical	26344197
PSMD9_HUMAN	PSMD9	physical	26344197
RD23A_HUMAN	RAD23A	physical	26344197
RD23B_HUMAN	RAD23B	physical	26344197
ADRM1_HUMAN	ADRM1	physical	26466095

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00188	Bortezomib

Regulatory Network of PSMD1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-273; THR-311 AND SER-315, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Mass spectrometric characterization of the affinity-purified human26S proteasome complex."; Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.; Biochemistry 46:3553-3565(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-311 AND SER-315,ACETYLATION AT MET-1, AND MASS SPECTROMETRY.	17323924 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-310, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-311 AND SER-315, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-273; THR-311 AND SER-315, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-273; SER-296; THR-311AND SER-315, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Mass spectrometric characterization of the affinity-purified human26S proteasome complex."; Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.; Biochemistry 46:3553-3565(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-311 AND SER-315,ACETYLATION AT MET-1, AND MASS SPECTROMETRY.	17323924 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-311 AND SER-315, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-273; THR-311 ANDSER-315, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Global phosphoproteome analysis on human HepG2 hepatocytes usingreversed-phase diagonal LC."; Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K.,Demol H., Martens L., Goethals M., Vandekerckhove J.; Proteomics 5:3589-3599(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-49, AND MASSSPECTROMETRY.	16097034 [Abstract]