ADRM1_MOUSE - dbPTM
ADRM1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADRM1_MOUSE
UniProt AC Q9JKV1
Protein Name Proteasomal ubiquitin receptor ADRM1
Gene Name Adrm1
Organism Mus musculus (Mouse).
Sequence Length 407
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex..
Protein Sequence MTTSGALFPSLVPGSRGSSTKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGTVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNECLNNPPMPGSLGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPASSSSSSSRSQSAAVTPSSSTSSARATPAPSAPAAASATSPSPAPSSGNGTSTAASPTQPIQLSDLQSILATMNVPAGPGGSQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKSDPKEGDTKDKKDEEEDMSLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTTSGALFP
------CCCCCCCCC		29.6629472430
2Acetylation------MTTSGALFP
------CCCCCCCCC		29.66-
3Phosphorylation-----MTTSGALFPS
-----CCCCCCCCCC		24.7029472430
4Phosphorylation----MTTSGALFPSL
----CCCCCCCCCCC		16.9529472430
10PhosphorylationTSGALFPSLVPGSRG
CCCCCCCCCCCCCCC		34.36357211719
15PhosphorylationFPSLVPGSRGSSTKY
CCCCCCCCCCCCCEE		27.6527566939
18PhosphorylationLVPGSRGSSTKYLVE
CCCCCCCCCCEEEEE		33.4526643407
19PhosphorylationVPGSRGSSTKYLVEF
CCCCCCCCCEEEEEE		31.5726643407
20PhosphorylationPGSRGSSTKYLVEFR
CCCCCCCCEEEEEEE		25.9626643407
21UbiquitinationGSRGSSTKYLVEFRA
CCCCCCCEEEEEEEC		38.2422790023
34UbiquitinationRAGKMSLKGTTVTPD
ECCCCEEECEEECCC		47.0722790023
42UbiquitinationGTTVTPDKRKGLVYI
CEEECCCCCCCEEEE		58.16-
83AcetylationFPDDCEFKRVPQCPS
CCCCCCCCCCCCCCC		30.147662993
88S-nitrosylationEFKRVPQCPSGRVYV
CCCCCCCCCCCCEEE		2.0721278135
88S-nitrosocysteineEFKRVPQCPSGRVYV
CCCCCCCCCCCCEEE		2.07-
140PhosphorylationMPGSLGASGSSGHEL
CCCCCCCCCCCCCHH		37.09-
211PhosphorylationSSSSSSRSQSAAVTP
CCCCCCCCCCCCCCC		30.3625521595
211O-linked_GlycosylationSSSSSSRSQSAAVTP
CCCCCCCCCCCCCCC		30.3630059200
213PhosphorylationSSSSRSQSAAVTPSS
CCCCCCCCCCCCCCC		21.3123684622
213O-linked_GlycosylationSSSSRSQSAAVTPSS
CCCCCCCCCCCCCCC		21.3130059200
217PhosphorylationRSQSAAVTPSSSTSS
CCCCCCCCCCCCCCC		16.8423527152
219PhosphorylationQSAAVTPSSSTSSAR
CCCCCCCCCCCCCCC		27.7923684622
220PhosphorylationSAAVTPSSSTSSARA
CCCCCCCCCCCCCCC		38.5525619855
221O-linked_GlycosylationAAVTPSSSTSSARAT
CCCCCCCCCCCCCCC		36.3230059200
221PhosphorylationAAVTPSSSTSSARAT
CCCCCCCCCCCCCCC		36.3225619855
222O-linked_GlycosylationAVTPSSSTSSARATP
CCCCCCCCCCCCCCC		28.7530059200
222PhosphorylationAVTPSSSTSSARATP
CCCCCCCCCCCCCCC		28.7525619855
223PhosphorylationVTPSSSTSSARATPA
CCCCCCCCCCCCCCC		24.7725619855
224PhosphorylationTPSSSTSSARATPAP
CCCCCCCCCCCCCCC		23.1225619855
238PhosphorylationPSAPAAASATSPSPA
CCCCCHHCCCCCCCC		27.6123649490
290PhosphorylationSQQVDLASVLTPEIM
CCCCCHHHHCCHHHH		25.5923649490
379UbiquitinationGDVEAFAKAMQNNAK
CCHHHHHHHHHHCCC		37.6322790023
395UbiquitinationDPKEGDTKDKKDEEE
CCCCCCCCCCHHHHH		72.75-
398UbiquitinationEGDTKDKKDEEEDMS
CCCCCCCHHHHHHCC		79.21-
405PhosphorylationKDEEEDMSLD-----
HHHHHHCCCC-----		41.5325521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADRM1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADRM1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADRM1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PSMD4_HUMANPSMD4physical
17139257
UBC_MOUSEUbcphysical
18497817
PRKN_HUMANPARK2physical
25666615
UBC_HUMANUBCphysical
25666615
SGTA_HUMANSGTAphysical
26169395
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADRM1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND MASSSPECTROMETRY.

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