| UniProt ID | PE2R1_HUMAN | |
|---|---|---|
| UniProt AC | P34995 | |
| Protein Name | Prostaglandin E2 receptor EP1 subtype | |
| Gene Name | PTGER1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 402 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.. | |
| Protein Sequence | MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | N-linked_Glycosylation | MSPCGPLNLSLAGEA CCCCCCCCCCCCCCC | 30.62 | UniProtKB CARBOHYD | |
| 25 | N-linked_Glycosylation | CAAPWVPNTSAVPPS CCCCCCCCCCCCCCC | 36.73 | UniProtKB CARBOHYD | |
| 262 | Phosphorylation | AHGPRSASASSASSI CCCCCCCCHHHHHHH | 29.90 | 30576142 | |
| 268 | Phosphorylation | ASASSASSIASASTF CCHHHHHHHHHHHCC | 23.14 | 30576142 | |
| 279 | Phosphorylation | ASTFFGGSRSSGSAR HHCCCCCCCCCCCCH | 29.39 | 30576142 | |
| 389 | Phosphorylation | TPSAWEASSLRSSRH CHHHHHHHHHHHHCC | 20.56 | 28857561 | |
| 390 | Phosphorylation | PSAWEASSLRSSRHS HHHHHHHHHHHHCCC | 34.55 | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PE2R1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PE2R1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PE2R1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PE2R1_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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