PPAL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPAL_HUMAN
• UniProt AC: P11117
• Protein Name: Lysosomal acid phosphatase
• Gene Name: ACP2
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Subcellular Localization: Lysosome membrane ; Single-pass membrane protein ; Lumenal side . Lysosome lumen. The soluble form arises by proteolytic processing of the membrane-bound form.
• Protein Sequence: MAGKRSGWSRAALLQLLLGVNLVVMPPTRARSLRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	LYRHGDRSPVKTYPK HHHCCCCCCCCCCCC	38.49	30576142
50	Phosphorylation	GDRSPVKTYPKDPYQ CCCCCCCCCCCCCCC	45.34	30576142
53	Ubiquitination	SPVKTYPKDPYQEEE CCCCCCCCCCCCCCC	62.00	-
92	N-linked_Glycosylation	QRYHGFLNTSYHRQE HHHHCCCCCCCCCEE	25.39	19159218
133	N-linked_Glycosylation	GMQRFNPNISWQPIP CCCCCCCCCCCCCCC	41.87	19159218
143	O-linked_Glycosylation	WQPIPVHTVPITEDR CCCCCCEEEECCCCC	28.36	OGP
153	Ubiquitination	ITEDRLLKFPLGPCP CCCCCCCCCCCCCCC	49.91	-
162	Phosphorylation	PLGPCPRYEQLQNET CCCCCCCHHHHHHHC	7.99	30576142
167	N-linked_Glycosylation	PRYEQLQNETRQTPE CCHHHHHHHCCCCHH	62.29	19159218
175	Phosphorylation	ETRQTPEYQNESSRN HCCCCHHHCCHHHHH	20.17	30576142
177	N-linked_Glycosylation	RQTPEYQNESSRNAQ CCCHHHCCHHHHHHH	50.66	19159218
179	Phosphorylation	TPEYQNESSRNAQFL CHHHCCHHHHHHHHH	41.99	30576142
180	Phosphorylation	PEYQNESSRNAQFLD HHHCCHHHHHHHHHH	24.31	30576142
191	N-linked_Glycosylation	QFLDMVANETGLTDL HHHHHHHHHCCCCCC	35.63	3056714
236	2-Hydroxyisobutyrylation	MQRLSRLKDFSFRFL HHHHHHHHHHHHHHH	56.47	-
239	Phosphorylation	LSRLKDFSFRFLFGI HHHHHHHHHHHHHHH	26.16	24719451
267	N-linked_Glycosylation	LLAQIRKNLTLMATT HHHHHHHCCEEEEEC	28.54	19159218
269	Phosphorylation	AQIRKNLTLMATTSQ HHHHHCCEEEEECCC	24.71	29978859
273	Phosphorylation	KNLTLMATTSQLPKL HCCEEEEECCCCCCC	17.02	29978859
274	Phosphorylation	NLTLMATTSQLPKLL CCEEEEECCCCCCCH	12.63	29978859
275	Phosphorylation	LTLMATTSQLPKLLV CEEEEECCCCCCCHH	25.93	24706070
322	N-linked_Glycosylation	LYQEDSGNFSVEMYF EEECCCCCEEEEEEE	29.94	3056714
331	N-linked_Glycosylation	SVEMYFRNESDKAPW EEEEEEECCCCCCCC	43.13	19159218

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPAL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPAL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPAL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UCRI_HUMAN	UQCRFS1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• H01113: Acid phosphatase deficiency
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-92; ASN-133; ASN-167;ASN-177; ASN-267 AND ASN-331, AND MASS SPECTROMETRY.
PubMed: 19159218