RN149_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN149_HUMAN
• UniProt AC: Q8NC42
• Protein Name: E3 ubiquitin-protein ligase RNF149
• Gene Name: RNF149
• Organism: Homo sapiens (Human).
• Sequence Length: 400
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation..
• Protein Sequence: MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRFGDSSPKEGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTFKDKVLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHRKETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPGDVQEMPAPESPPGRDPAANLSLALPDDDGSDDSSPPSASPAESEPQCDPSFKGDAGENTALLEAGRSDSRHGGPIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	N-linked_Glycosylation	EYVDPQTNLTVWSVS EEECCCCCEEEEEEE	28.59	UniProtKB CARBOHYD
80	Ubiquitination	AHGLVGVPWAPGGDL CCCCCCCCCCCCCCC	18.64	23000965
83	Ubiquitination	LVGVPWAPGGDLEGC CCCCCCCCCCCCCCC	43.35	23000965
84	Ubiquitination	VGVPWAPGGDLEGCA CCCCCCCCCCCCCCC	34.20	21890473
95	Ubiquitination	EGCAPDTRFFVPEPG CCCCCCCEEECCCCC	30.31	22817900
99	Ubiquitination	PDTRFFVPEPGGRGA CCCEEECCCCCCCCC	36.59	21963094
127	Ubiquitination	FKDKVLVAARRNASA CCCHHHHEECCCCCE	7.35	23000965
145	N-linked_Glycosylation	YNEERYGNITLPMSH ECCCCCCEEEEECCC	18.35	UniProtKB CARBOHYD
149	Ubiquitination	RYGNITLPMSHAGTG CCCEEEEECCCCCCC	17.36	21963094
154	Ubiquitination	TLPMSHAGTGNIVVI EEECCCCCCCCEEEE	28.82	22817900
164	Phosphorylation	NIVVIMISYPKGREI CEEEEEEEECCCHHH	20.29	24719451
238	Phosphorylation	GSQIGSQSHRKETKK CCCCCCHHHHHHHHH	27.27	28674419
241	Ubiquitination	IGSQSHRKETKKVIG CCCHHHHHHHHHHHH	65.40	23000965
244	Ubiquitination	QSHRKETKKVIGQLL HHHHHHHHHHHHHHH	46.24	23000965
245	Ubiquitination	SHRKETKKVIGQLLL HHHHHHHHHHHHHHH	46.64	23000965
254	Phosphorylation	IGQLLLHTVKHGEKG HHHHHHHHHHCCCCC	31.08	28555341
256	Ubiquitination	QLLLHTVKHGEKGID HHHHHHHHCCCCCCC	47.23	33845483
260	Ubiquitination	HTVKHGEKGIDVDAE HHHHCCCCCCCCCHH	66.80	21963094
277	Ubiquitination	AVCIENFKVKDIIRI EEEECCCCHHHEEEE	61.02	32015554
279	Ubiquitination	CIENFKVKDIIRILP EECCCCHHHEEEEEE	43.74	-
288	Ubiquitination	IIRILPCKHIFHRIC EEEEEECCCHHHHHH	37.48	23000965
310	Ubiquitination	HRTCPMCKLDVIKAL CCCCCCCCHHHHHHH	41.28	21963094
315	Ubiquitination	MCKLDVIKALGYWGE CCCHHHHHHHCCCCC	37.09	21906983
319	Phosphorylation	DVIKALGYWGEPGDV HHHHHHCCCCCCCCC	15.87	25884760
334	Phosphorylation	QEMPAPESPPGRDPA CCCCCCCCCCCCCCC	35.02	21815630
345	Phosphorylation	RDPAANLSLALPDDD CCCCCCEEEECCCCC	16.05	-
383	Phosphorylation	KGDAGENTALLEAGR CCCCCCCCEEHHCCC	17.87	21815630
393	Phosphorylation	LEAGRSDSRHGGPIS HHCCCCCCCCCCCCC	27.68	28787133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN149_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN149_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN149_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RN149_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.