TEN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEN3_HUMAN
• UniProt AC: Q9P273
• Protein Name: Teneurin-3 {ECO:0000305}
• Gene Name: TENM3 {ECO:0000312|HGNC:HGNC:29944}
• Organism: Homo sapiens (Human).
• Sequence Length: 2699
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Cell projection, axon .
• Protein Description: Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes..
• Protein Sequence: MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSENEQPASNQGQSTLQPLPPSHKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENGKVNSDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQQQVARQAKAFLSLGKMAEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	DVKERRPYCSLTKSR CHHHCCCCCCCCHHH	7.89	30266825
11	Phosphorylation	KERRPYCSLTKSRRE HHCCCCCCCCHHHHH	32.98	30266825
13	Phosphorylation	RRPYCSLTKSRREKE CCCCCCCCHHHHHHH	15.64	30266825
23	Phosphorylation	RREKERRYTNSSADN HHHHHHCCCCCCCCC	19.25	23312004
24	Phosphorylation	REKERRYTNSSADNE HHHHHCCCCCCCCCC	27.15	30576142
26	Phosphorylation	KERRYTNSSADNEEC HHHCCCCCCCCCCCC	21.07	30576142
27	Phosphorylation	ERRYTNSSADNEECR HHCCCCCCCCCCCCC	41.53	25850435
41	Phosphorylation	RVPTQKSYSSSETLK CCCCCCCCCCCHHHH	21.43	25884760
43	Phosphorylation	PTQKSYSSSETLKAF CCCCCCCCCHHHHCC	24.78	30576142
55	Phosphorylation	KAFDHDSSRLLYGNR HCCCCCHHHHHHCHH	32.76	26546556
59	Phosphorylation	HDSSRLLYGNRVKDL CCHHHHHHCHHHHHH	19.56	25884760
82	Phosphorylation	TRQGQNFTLRQLGVC HHHCCCEEEHHCCCC	28.69	24719451
110	Phosphorylation	MGLPHRGYSISAGSD CCCCCCCEEECCCCC	11.64	27642862
111	Phosphorylation	GLPHRGYSISAGSDA CCCCCCEEECCCCCC	16.94	23927012
113	Phosphorylation	PHRGYSISAGSDADT CCCCEEECCCCCCCC	22.19	25850435
116	Phosphorylation	GYSISAGSDADTENE CEEECCCCCCCCCCC	29.37	25850435
120	Phosphorylation	SAGSDADTENEAVMS CCCCCCCCCCCCCCC	42.29	25850435
127	Phosphorylation	TENEAVMSPEHAMRL CCCCCCCCHHHHHHH	22.12	25850435
149	Phosphorylation	GRSSCLSSRSNSALT CCHHHCCCCCCCCEE	27.12	-
151	Phosphorylation	SSCLSSRSNSALTLT HHHCCCCCCCCEEEE	36.76	24144214
153	Phosphorylation	CLSSRSNSALTLTDT HCCCCCCCCEEEECC	26.38	21815630
156	Phosphorylation	SRSNSALTLTDTEHE CCCCCCEEEECCCCC	27.59	24144214
158	Phosphorylation	SNSALTLTDTEHENK CCCCEEEECCCCCCC	35.32	21815630
160	Phosphorylation	SALTLTDTEHENKSD CCEEEECCCCCCCCC	33.72	24144214
166	Phosphorylation	DTEHENKSDSENEQP CCCCCCCCCCCCCCC	58.93	24144214
168	Phosphorylation	EHENKSDSENEQPAS CCCCCCCCCCCCCCC	49.79	24144214
175	Phosphorylation	SENEQPASNQGQSTL CCCCCCCCCCCCCCC	36.05	24144214
180	Phosphorylation	PASNQGQSTLQPLPP CCCCCCCCCCCCCCC	37.60	24144214
181	Phosphorylation	ASNQGQSTLQPLPPS CCCCCCCCCCCCCCC	22.86	24144214
188	Phosphorylation	TLQPLPPSHKQHSAQ CCCCCCCCCCCCCCC	41.18	24144214
199	Phosphorylation	HSAQHHPSITSLNRN CCCCCCCCHHHCCHH	33.86	29449344
201	Phosphorylation	AQHHPSITSLNRNSL CCCCCCHHHCCHHHC	31.34	29523821
202	Phosphorylation	QHHPSITSLNRNSLT CCCCCHHHCCHHHCC	23.21	29523821
207	Phosphorylation	ITSLNRNSLTNRRNQ HHHCCHHHCCCCCCC	33.08	29523821
209	Phosphorylation	SLNRNSLTNRRNQSP HCCHHHCCCCCCCCC	26.88	29523821
256	Phosphorylation	SRHFLFKTGTGTTPL CCCEEEECCCCCCCC	32.42	21945579
258	Phosphorylation	HFLFKTGTGTTPLFS CEEEECCCCCCCCCC	36.26	21945579
260	Phosphorylation	LFKTGTGTTPLFSTA EEECCCCCCCCCCCC	25.69	21945579
261	Phosphorylation	FKTGTGTTPLFSTAT EECCCCCCCCCCCCC	21.24	21945579
265	Phosphorylation	TGTTPLFSTATPGYT CCCCCCCCCCCCCCE	25.47	21945579
266	Phosphorylation	GTTPLFSTATPGYTM CCCCCCCCCCCCCEE	27.50	21945579
268	Phosphorylation	TPLFSTATPGYTMAS CCCCCCCCCCCEECC	19.82	21945579
271	Phosphorylation	FSTATPGYTMASGSV CCCCCCCCEECCCCC	8.44	21945579
272	Phosphorylation	STATPGYTMASGSVY CCCCCCCEECCCCCC	16.51	21945579
275	Phosphorylation	TPGYTMASGSVYSPP CCCCEECCCCCCCCC	22.30	21945579
277	Phosphorylation	GYTMASGSVYSPPTR CCEECCCCCCCCCCC	18.52	21945579
279	Phosphorylation	TMASGSVYSPPTRPL EECCCCCCCCCCCCC	19.70	21945579
280	Phosphorylation	MASGSVYSPPTRPLP ECCCCCCCCCCCCCC	23.42	21945579
283	Phosphorylation	GSVYSPPTRPLPRNT CCCCCCCCCCCCCCC	48.59	21945579
345	N-linked_Glycosylation	WQLQQTENDTFENGK CCEEECCCCCCCCCC	57.94	UniProtKB CARBOHYD
355	Phosphorylation	FENGKVNSDTMPTNT CCCCCCCCCCCCCCE	37.13	-
362	Phosphorylation	SDTMPTNTVSLPSGD CCCCCCCEEECCCCC	17.60	-
367	Phosphorylation	TNTVSLPSGDNGKLG CCEEECCCCCCCCCC	65.16	-
380	N-linked_Glycosylation	LGGFTQENNTIDSGE CCCCEECCCEECCCC	40.92	UniProtKB CARBOHYD
419	N-linked_Glycosylation	QPQFLKFNISLQKDA CCCCEEEEEEECCCC	22.73	UniProtKB CARBOHYD
421	Phosphorylation	QFLKFNISLQKDALI CCEEEEEEECCCCEE	26.33	24719451
474	Phosphorylation	RAGRQARSVSLHEAG HHHHHCCCEEHHHHC	21.05	26074081
476	Phosphorylation	GRQARSVSLHEAGFI HHHCCCEEHHHHCHH	25.84	26074081
485	Phosphorylation	HEAGFIQYLDSGIWH HHHCHHHHHHCCCEE	13.99	26074081
554	Phosphorylation	AACPVLCSGNGQYSK CCCCEEECCCCCCCC	31.00	-
559	Phosphorylation	LCSGNGQYSKGRCLC EECCCCCCCCCEEEE	17.47	-
560	Phosphorylation	CSGNGQYSKGRCLCF ECCCCCCCCCEEEEC	22.27	-
670	N-linked_Glycosylation	GSCTCDPNWTGPDCS CCEEECCCCCCCCCC	35.37	UniProtKB CARBOHYD
835	Ubiquitination	SPSQQAAKSFYDRIS CHHHHHHHHHHHHHH	44.08	21906983
860	N-linked_Glycosylation	IPGESPFNKSLASVI CCCCCCCCHHHHHHH	36.07	UniProtKB CARBOHYD
883	N-linked_Glycosylation	GTPLIGVNVSFFHYP CCEEEEEEEEEEECC	20.64	UniProtKB CARBOHYD
889	Phosphorylation	VNVSFFHYPEYGYTI EEEEEEECCCCCEEE	7.81	-
1006	Phosphorylation	GTDLKLSYLSSRAAG CCHHHHHHHHHHCCC	22.50	22817900
1104	Phosphorylation	RTAILQGYELDASNM HHHHHHCCEECCCCC	10.60	-
1130	Phosphorylation	DVQNGILYKGNGENQ EECCCEEEECCCCCC	18.22	-
1187	Phosphorylation	CGIDGSLYVGDFNYV HCCCCEEEECCCCCE	12.23	-
1193	Phosphorylation	LYVGDFNYVRRIFPS EEECCCCCEEEECCC	8.70	-
1202	N-linked_Glycosylation	RRIFPSGNVTSVLEL EEECCCCCEEEEEEE	37.93	UniProtKB CARBOHYD
1210	Phosphorylation	VTSVLELSSNPAHRY EEEEEEECCCCCCEE	20.77	22210691
1211	Phosphorylation	TSVLELSSNPAHRYY EEEEEECCCCCCEEE	60.50	22210691
1217	Phosphorylation	SSNPAHRYYLATDPV CCCCCCEEEEECCCC	7.92	22817900
1218	Phosphorylation	SNPAHRYYLATDPVT CCCCCEEEEECCCCC	6.99	22817900
1225	Phosphorylation	YLATDPVTGDLYVSD EEECCCCCCCEEECC	30.30	24719451
1338	Phosphorylation	CDTSMHISQVRLEWP CCCCEEEEEEEEECC	14.14	23532336
1527	N-linked_Glycosylation	ELYIFDINGTHQYTV EEEEEEECCCEEEEE	51.67	UniProtKB CARBOHYD
1544	N-linked_Glycosylation	VTGDYLYNFSYSNDN EECCEEEEEECCCCC	19.45	UniProtKB CARBOHYD
1579	Phosphorylation	RMPVRVVSPDNQVIW CCCEEEECCCCCEEE	24.55	-
1640	N-linked_Glycosylation	DSEGRLTNVTFPTGV CCCCCEEEEEECCCC	35.11	UniProtKB CARBOHYD
1660	Phosphorylation	GDMDKAITVDIESSS CCCCCEEEEECCCCC	19.58	-
1677	N-linked_Glycosylation	EDVSITSNLSSIDSF CCCCCCCCCCHHHHH	34.98	UniProtKB CARBOHYD
1695	Phosphorylation	VQDQLRNSYQIGYDG HHHHHHHCCCCCCCC	16.39	29759185
1696	Phosphorylation	QDQLRNSYQIGYDGS HHHHHHCCCCCCCCC	14.01	29759185
1735	N-linked_Glycosylation	NPTVAKRNMTLPGEN CCCHHHCCEECCCCC	27.38	UniProtKB CARBOHYD
1782	Phosphorylation	LSVDFDRTTKTEKIY EEEECCCCCCCEECC	34.19	24719451
1785	Phosphorylation	DFDRTTKTEKIYDDH ECCCCCCCEECCHHH	40.18	24719451
1804	Phosphorylation	LRIAYDTSGHPTLWL HHHHHCCCCCCEEEE	32.01	22210691
1820	N-linked_Glycosylation	SSKLMAVNVTYSSTG CCCEEEEEEEECCCC	15.75	UniProtKB CARBOHYD
1822	Phosphorylation	KLMAVNVTYSSTGQI CEEEEEEEECCCCCE	16.69	22210691
1862	Phosphorylation	ADGKTWSYTYLEKSM CCCCEEEEEEHHHHH	7.32	-
1864	Phosphorylation	GKTWSYTYLEKSMVL CCEEEEEEHHHHHHH	12.48	-
1901	Phosphorylation	MPSVARHTMQTIRSI CHHHHHHHHHHHHHH	12.86	-
1921	N-linked_Glycosylation	IYNPPESNASIITDY CCCCCCCCCCCCCCC	35.72	UniProtKB CARBOHYD
1923	O-linked_Glycosylation	NPPESNASIITDYNE CCCCCCCCCCCCCCC	20.83	29351928
1926	O-linked_Glycosylation	ESNASIITDYNEEGL CCCCCCCCCCCCCCC	30.66	29351928
1967	O-linked_Glycosylation	LYDSTRVSFTYDETA HHCCCCEEEEEECCC	14.47	29351928
1969	Phosphorylation	DSTRVSFTYDETAGV CCCCEEEEEECCCCE	23.66	-
1979	Phosphorylation	ETAGVLKTVNLQSDG CCCCEEEEEEECCCC	15.51	23312004
1984	Phosphorylation	LKTVNLQSDGFICTI EEEEEECCCCEEEEE	42.75	23312004
1990	Phosphorylation	QSDGFICTIRYRQIG CCCCEEEEEEEEECH	12.04	23312004
1993	Phosphorylation	GFICTIRYRQIGPLI CEEEEEEEEECHHCC	11.74	23312004
2097	Phosphorylation	IQYEIFRSLMYWITI HHHHHHHHHHHHHHC	13.51	26503514
2100	Phosphorylation	EIFRSLMYWITIQYD HHHHHHHHHHHCCCC	10.04	26503514
2103	Phosphorylation	RSLMYWITIQYDNMG HHHHHHHHCCCCCCC	6.46	26503514
2106	Phosphorylation	MYWITIQYDNMGRVT HHHHHCCCCCCCCEE	12.87	26503514
2124	N-linked_Glycosylation	IKIGPFANTTKYAYE EEEECCCCCCEEEEE	48.97	UniProtKB CARBOHYD
2125	Phosphorylation	KIGPFANTTKYAYEY EEECCCCCCEEEEEE	22.64	-
2126	Phosphorylation	IGPFANTTKYAYEYD EECCCCCCEEEEEEC	23.12	-
2128	Phosphorylation	PFANTTKYAYEYDVD CCCCCCEEEEEECCC	16.60	22817900
2142	Phosphorylation	DGQLQTVYLNEKIMW CCCEEEEEECCEEEE	13.75	22817900
2207	Phosphorylation	RGTEIFEYSSKGLLT CCCEEEEECCCCEEE	13.90	-
2217	Phosphorylation	KGLLTRVYSKGSGWT CCEEEEEEECCCCEE	11.02	-
2227	Phosphorylation	GSGWTVIYRYDGLGR CCCEEEEEEECCCCC	9.97	-
2229	Phosphorylation	GWTVIYRYDGLGRRV CEEEEEEECCCCCEE	9.44	-
2264	N-linked_Glycosylation	TRITHVYNHSSSEIT CEEEEEECCCCCCEE	27.72	UniProtKB CARBOHYD
2385	Phosphorylation	DPAPFNLYMFRNNNP CCCCCCEEEECCCCC	8.70	26552605
2494	Phosphorylation	LWFATVKSLIGKGVM HHHHHHHHHHCCCCE	22.38	-
2505	Phosphorylation	KGVMLAVSQGRVQTN CCCEEEEECCCCCCC	22.70	29496963
2554	Phosphorylation	HYFIKTTTPESDLGT EEEEEECCCHHHCCC	30.23	-
2557	Phosphorylation	IKTTTPESDLGTLRL EEECCCHHHCCCEEE	39.06	-
2561	Phosphorylation	TPESDLGTLRLTSGR CCHHHCCCEEECCHH	18.92	-
2566	Phosphorylation	LGTLRLTSGRKALEN CCCEEECCHHHHHHC	40.99	28387310
2576	N-linked_Glycosylation	KALENGINVTVSQST HHHHCCCEEEEECCE	25.46	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEN3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TEN3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615145: Microphthalmia, isolated, with coloboma, 9 (MCOPCB9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.