MFAP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFAP3_HUMAN
• UniProt AC: P55082
• Protein Name: Microfibril-associated glycoprotein 3
• Gene Name: MFAP3
• Organism: Homo sapiens (Human).
• Sequence Length: 362
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Component of the elastin-associated microfibrils..
• Protein Sequence: MKLHCCLFTLVASIIVPAAFVLEDVDFDQMVSLEANRSSYNASFPSSFELSASSHSDDDVIIAKEGTSVSIECLLTASHYEDVHWHNSKGQQLDGRSRGGKWLVSDNFLNITNVAFDDRGLYTCFVTSPIRASYSVTLRVIFTSGDMSVYYMIVCLIAFTITLILNVTRLCMMSSHLRKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLILNCRAFVEEMFEAVRVDDPDDLGERIKERPALNAQGGIYVINPEMGRSNSPGGDSDDGSLNEQGQEIAVQVSVHLQSETKSIDTESQGSSHFSPPDDIGSAESNCNYKDGAYENCQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	VDFDQMVSLEANRSS CCHHHEEEEEECHHC	18.36	-
33	Ubiquitination	DFDQMVSLEANRSSY CHHHEEEEEECHHCC	4.98	23000965
36	Ubiquitination	QMVSLEANRSSYNAS HEEEEEECHHCCCCC	34.68	23000965
36	N-linked_Glycosylation	QMVSLEANRSSYNAS HEEEEEECHHCCCCC	34.68	UniProtKB CARBOHYD
41	N-linked_Glycosylation	EANRSSYNASFPSSF EECHHCCCCCCCCCE	30.93	UniProtKB CARBOHYD
49	Ubiquitination	ASFPSSFELSASSHS CCCCCCEEEECCCCC	43.70	23000965
52	Ubiquitination	PSSFELSASSHSDDD CCCEEEECCCCCCCC	27.90	21890473
52	Ubiquitination	PSSFELSASSHSDDD CCCEEEECCCCCCCC	27.90	23000965
58	Ubiquitination	SASSHSDDDVIIAKE ECCCCCCCCEEEECC	55.90	23000965
67	Ubiquitination	VIIAKEGTSVSIECL EEEECCCCEEEEEEE	27.35	21890473
67	Ubiquitination	VIIAKEGTSVSIECL EEEECCCCEEEEEEE	27.35	23000965
73	Ubiquitination	GTSVSIECLLTASHY CCEEEEEEEEECHHC	3.44	23000965
73	Ubiquitination	GTSVSIECLLTASHY CCEEEEEEEEECHHC	3.44	21890473
78	Ubiquitination	IECLLTASHYEDVHW EEEEEECHHCCCCCC	22.74	23000965
78	Ubiquitination	IECLLTASHYEDVHW EEEEEECHHCCCCCC	22.74	21890473
110	N-linked_Glycosylation	LVSDNFLNITNVAFD EECCCEECEEEEEEC	34.60	UniProtKB CARBOHYD
137	Phosphorylation	IRASYSVTLRVIFTS CEECEEEEEEEEEEC	11.69	24719451
143	Phosphorylation	VTLRVIFTSGDMSVY EEEEEEEECCCHHHH	22.22	24043423
144	Phosphorylation	TLRVIFTSGDMSVYY EEEEEEECCCHHHHH	23.26	24043423
148	Phosphorylation	IFTSGDMSVYYMIVC EEECCCHHHHHHHHH	16.23	24043423
150	Phosphorylation	TSGDMSVYYMIVCLI ECCCHHHHHHHHHHH	4.68	24043423
151	Phosphorylation	SGDMSVYYMIVCLIA CCCHHHHHHHHHHHH	4.35	24043423
160	Phosphorylation	IVCLIAFTITLILNV HHHHHHHHHHHHHHH	12.20	24043423
162	Phosphorylation	CLIAFTITLILNVTR HHHHHHHHHHHHHHH	12.51	24043423
168	Phosphorylation	ITLILNVTRLCMMSS HHHHHHHHHHHHHHH	19.49	24043423
174	Phosphorylation	VTRLCMMSSHLRKTE HHHHHHHHHHHHHHH	6.42	24043423
175	Phosphorylation	TRLCMMSSHLRKTEK HHHHHHHHHHHHHHH	14.51	24043423
179	Ubiquitination	MMSSHLRKTEKAINE HHHHHHHHHHHHHHH	68.35	23000965
182	Ubiquitination	SHLRKTEKAINEFFR HHHHHHHHHHHHHHH	60.85	23000965
195	Ubiquitination	FRTEGAEKLQKAFEI HHHHHHHHHHHHHHH	56.54	23000965
198	Ubiquitination	EGAEKLQKAFEIAKR HHHHHHHHHHHHHHH	66.53	23000965
204	Ubiquitination	QKAFEIAKRIPIITS HHHHHHHHHCCEEEC	57.43	23000965
210	Phosphorylation	AKRIPIITSAKTLEL HHHCCEEECCCHHHH	24.29	26471730
211	Phosphorylation	KRIPIITSAKTLELA HHCCEEECCCHHHHH	19.84	26471730
213	Ubiquitination	IPIITSAKTLELAKV CCEEECCCHHHHHHH	54.10	23000965
219	Ubiquitination	AKTLELAKVTQFKTM CCHHHHHHHHCCCHH	59.44	23000965
224	Ubiquitination	LAKVTQFKTMEFARY HHHHHCCCHHHHHHH	36.82	23000965
272	Ubiquitination	DDLGERIKERPALNA CHHHHHHHHCCCCCC	54.62	-
284	Phosphorylation	LNAQGGIYVINPEMG CCCCCCEEEECCCCC	9.88	21945579
293	Phosphorylation	INPEMGRSNSPGGDS ECCCCCCCCCCCCCC	35.61	26471730
295	Phosphorylation	PEMGRSNSPGGDSDD CCCCCCCCCCCCCCC	26.60	26471730
300	Phosphorylation	SNSPGGDSDDGSLNE CCCCCCCCCCCCCCH	40.66	26471730
326	Phosphorylation	HLQSETKSIDTESQG EEEECCEECCCCCCC	32.87	28450419
329	Phosphorylation	SETKSIDTESQGSSH ECCEECCCCCCCCCC	35.55	28450419
331	Phosphorylation	TKSIDTESQGSSHFS CEECCCCCCCCCCCC	41.77	28450419
334	Phosphorylation	IDTESQGSSHFSPPD CCCCCCCCCCCCCCC	17.01	28450419
335	Phosphorylation	DTESQGSSHFSPPDD CCCCCCCCCCCCCCC	35.06	28450419
338	Phosphorylation	SQGSSHFSPPDDIGS CCCCCCCCCCCCCCC	30.05	28450419
357	Phosphorylation	CNYKDGAYENCQL-- CCCCCCCCCCCCC--	17.13	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MFAP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFAP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFAP3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MFAP3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.