GHITM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GHITM_HUMAN
• UniProt AC: Q9H3K2
• Protein Name: Growth hormone-inducible transmembrane protein
• Gene Name: GHITM
• Organism: Homo sapiens (Human).
• Sequence Length: 345
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c..
• Protein Sequence: MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKIDQMGRWFVAGGAAVGLGALCYYGLGLSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSAIAISRTPVLMNFMMRGSWVTIGVTFAAMVGAGMLVRSIPYDQSPGPKHLAWLLHSGVMGAVVAPLTILGGPLLIRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFVSSLGSMFLPPTTVAGATLYSVAMYGGLVLFSMFLLYDTQKVIKRAEVSPMYGVQKYDPINSMLSIYMDTLNIFMRVATMLATGGNRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	VFHPAFTKASPVVKN HCCCCCCCCCCCCCC	40.17	27667366
29	Ubiquitination	TKASPVVKNSITKNQ CCCCCCCCCCCCCCC	45.25	32142685
34	Ubiquitination	VVKNSITKNQWLLTP CCCCCCCCCCEEECC	45.53	32142685
40	Phosphorylation	TKNQWLLTPSREYAT CCCCEEECCCHHHHC	19.63	25159151
49	Phosphorylation	SREYATKTRIGIRRG CHHHHCHHCCCCCCC	24.14	24719451
58	O-linked_Glycosylation	IGIRRGRTGQELKEA CCCCCCCCHHHHHHH	46.14	30379171
63	Ubiquitination	GRTGQELKEAALEPS CCCHHHHHHHHHCHH	44.55	29967540
70	Phosphorylation	KEAALEPSMEKIFKI HHHHHCHHHHHHHHH	30.14	-
73	Ubiquitination	ALEPSMEKIFKIDQM HHCHHHHHHHHHHHC	44.81	23503661
73	Acetylation	ALEPSMEKIFKIDQM HHCHHHHHHHHHHHC	44.81	26051181
73	2-Hydroxyisobutyrylation	ALEPSMEKIFKIDQM HHCHHHHHHHHHHHC	44.81	-
76	Ubiquitination	PSMEKIFKIDQMGRW HHHHHHHHHHHCCCE	49.17	24816145
121	2-Hydroxyisobutyrylation	VIWPQYVKDRIHSTY CCCHHHHHHHHHHHH	36.03	-
121	Acetylation	VIWPQYVKDRIHSTY CCCHHHHHHHHHHHH	36.03	27452117
129	Sulfoxidation	DRIHSTYMYLAGSIG HHHHHHHHHHHHHHH	1.93	28183972
185	Phosphorylation	RSIPYDQSPGPKHLA ECCCCCCCCCHHHHH	29.00	-
308	Nitration	RAEVSPMYGVQKYDP HHHCCCCCCCCCCCH	19.96	-
313	Phosphorylation	PMYGVQKYDPINSML CCCCCCCCCHHHHHH	15.17	-
336	Sulfoxidation	IFMRVATMLATGGNR HHHHHHHHHHHCCCC	1.40	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GHITM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GHITM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GHITM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SARM1_HUMAN	SARM1	physical	28514442
CL073_HUMAN	C12orf73	physical	28514442
MFN2_HUMAN	MFN2	physical	28514442
ANKL2_HUMAN	ANKLE2	physical	28514442
MFR1L_HUMAN	MTFR1L	physical	28514442
5NT3A_HUMAN	NT5C3A	physical	28514442
SG196_HUMAN	POMK	physical	28514442
GLPK_HUMAN	GK	physical	28514442
SELH_HUMAN	C11orf31	physical	28514442
CCNB2_HUMAN	CCNB2	physical	28514442
F162A_HUMAN	FAM162A	physical	28514442
PTN1_HUMAN	PTPN1	physical	28514442
SLTM_HUMAN	SLTM	physical	28514442
CGL_HUMAN	CTH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.