GLPK_HUMAN - dbPTM
GLPK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLPK_HUMAN
UniProt AC P32189
Protein Name Glycerol kinase
Gene Name GK
Organism Homo sapiens (Human).
Sequence Length 559
Subcellular Localization Mitochondrion outer membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasm. In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
Protein Description Key enzyme in the regulation of glycerol uptake and metabolism..
Protein Sequence MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAASKKAVLGP
----CCCCCHHHHHC		25.7522673903
5Ubiquitination---MAASKKAVLGPL
---CCCCCHHHHHCC		39.7721890473
5Ubiquitination---MAASKKAVLGPL
---CCCCCHHHHHCC		39.7721890473
5 (in isoform 1)Ubiquitination-39.7721890473
5Ubiquitination---MAASKKAVLGPL
---CCCCCHHHHHCC		39.7721890473
5 (in isoform 3)Ubiquitination-39.7721890473
6 (in isoform 3)Ubiquitination-41.0321890473
6Ubiquitination--MAASKKAVLGPLV
--CCCCCHHHHHCCC		41.0321890473
6 (in isoform 2)Ubiquitination-41.0321890473
6Ubiquitination--MAASKKAVLGPLV
--CCCCCHHHHHCCC		41.0321890473
6Ubiquitination--MAASKKAVLGPLV
--CCCCCHHHHHCCC		41.0321890473
6 (in isoform 1)Ubiquitination-41.0321890473
20PhosphorylationVGAVDQGTSSTRFLV
CCCCCCCCCCCEEEE		17.5528857561
21PhosphorylationGAVDQGTSSTRFLVF
CCCCCCCCCCEEEEE		36.2128857561
22PhosphorylationAVDQGTSSTRFLVFN
CCCCCCCCCEEEEEC		24.3628857561
23PhosphorylationVDQGTSSTRFLVFNS
CCCCCCCCEEEEECH		25.8028857561
31 (in isoform 3)Ubiquitination-53.5121890473
31 (in isoform 2)Ubiquitination-53.5121890473
31UbiquitinationRFLVFNSKTAELLSH
EEEEECHHHHHHHHC		53.5121890473
31UbiquitinationRFLVFNSKTAELLSH
EEEEECHHHHHHHHC		53.5121890473
31 (in isoform 1)Ubiquitination-53.5121890473
31UbiquitinationRFLVFNSKTAELLSH
EEEEECHHHHHHHHC		53.5121890473
83PhosphorylationGQLNIDISNIKAIGV
CCCEEEHHCEEEEEE		28.8428857561
86 (in isoform 3)Ubiquitination-37.9021890473
86UbiquitinationNIDISNIKAIGVSNQ
EEEHHCEEEEEECCC		37.9021890473
86 (in isoform 1)Ubiquitination-37.9021890473
86 (in isoform 2)Ubiquitination-37.9021890473
86UbiquitinationNIDISNIKAIGVSNQ
EEEHHCEEEEEECCC		37.9021890473
86UbiquitinationNIDISNIKAIGVSNQ
EEEHHCEEEEEECCC		37.9021890473
119PhosphorylationVVWLDLRTQSTVESL
EEEEECCCHHHHHHH		33.8826437602
121PhosphorylationWLDLRTQSTVESLSK
EEECCCHHHHHHHHH		33.5326437602
125PhosphorylationRTQSTVESLSKRIPG
CCHHHHHHHHHCCCC		33.3428857561
127PhosphorylationQSTVESLSKRIPGNN
HHHHHHHHHCCCCCC		29.2128857561
128 (in isoform 1)Ubiquitination-60.69-
139PhosphorylationGNNNFVKSKTGLPLS
CCCCCCCCCCCCCHH		30.1022210691
141PhosphorylationNNFVKSKTGLPLSTY
CCCCCCCCCCCHHHH		51.5522210691
146PhosphorylationSKTGLPLSTYFSAVK
CCCCCCHHHHHHHHH		21.0829978859
147PhosphorylationKTGLPLSTYFSAVKL
CCCCCHHHHHHHHHH		35.9529978859
148PhosphorylationTGLPLSTYFSAVKLR
CCCCHHHHHHHHHHH		7.6722210691
150PhosphorylationLPLSTYFSAVKLRWL
CCHHHHHHHHHHHHH		23.0322210691
287PhosphorylationQAKNTYGTGCFLLCN
CCCCCCCCCEEEEEC		21.9928857561
302PhosphorylationTGHKCVFSDHGLLTT
CCCCCEEECCCHHHH		14.3230631047
321PhosphorylationLGRDKPVYYALEGSV
HCCCCCEEEEEECHH		7.4929083192
322PhosphorylationGRDKPVYYALEGSVA
CCCCCEEEEEECHHH		12.6329083192
327PhosphorylationVYYALEGSVAIAGAV
EEEEEECHHHHHHHH		10.0529083192
340 (in isoform 2)Ubiquitination-53.1621890473
340 (in isoform 1)Ubiquitination-53.1621890473
346 (in isoform 3)Ubiquitination-44.0421890473
346UbiquitinationRDNLGIIKTSEEIEK
HHHCCCCCCHHHHHH		44.0421890473
346UbiquitinationRDNLGIIKTSEEIEK
HHHCCCCCCHHHHHH		44.0421890473
346UbiquitinationRDNLGIIKTSEEIEK
HHHCCCCCCHHHHHH		44.0421890473
347 (in isoform 1)Ubiquitination-30.8421890473
347 (in isoform 2)Ubiquitination-30.8421890473
347PhosphorylationDNLGIIKTSEEIEKL
HHCCCCCCHHHHHHH		30.8428857561
348PhosphorylationNLGIIKTSEEIEKLA
HCCCCCCHHHHHHHH		28.3828857561
353 (in isoform 3)Ubiquitination-60.4521890473
353UbiquitinationKTSEEIEKLAKEVGT
CCHHHHHHHHHHHCC		60.452190698
515 (in isoform 1)Phosphorylation-30.6025159151
516 (in isoform 1)Phosphorylation-12.3925159151
518 (in isoform 1)Phosphorylation-23.8525159151
521 (in isoform 4)Phosphorylation-16.7725159151
521 (in isoform 1)Phosphorylation-16.7725159151
522 (in isoform 4)Phosphorylation-19.8925159151
524 (in isoform 4)Phosphorylation-28.6625159151
527 (in isoform 4)Phosphorylation-52.4525159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLPK_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLPK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLPK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IPO13_HUMANIPO13physical
21988832
GPDA_HUMANGPD1physical
21988832
NR4A1_HUMANNR4A1physical
21988832
RXRA_HUMANRXRAphysical
21988832
OPLA_HUMANOPLAHphysical
21988832
SG1D2_HUMANSCGB1D2physical
28514442
UBIP1_HUMANUBP1physical
28514442
HBB_HUMANHBBphysical
28514442
APOD_HUMANAPODphysical
28514442
ZA2G_HUMANAZGP1physical
28514442
Drug and Disease Associations
Kegg Disease
H00552 Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; X
OMIM Disease
307030Glycerol kinase deficiency (GKD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLPK_HUMAN

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Related Literatures of Post-Translational Modification

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