OPLA_HUMAN - dbPTM
OPLA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPLA_HUMAN
UniProt AC O14841
Protein Name 5-oxoprolinase
Gene Name OPLAH
Organism Homo sapiens (Human).
Sequence Length 1288
Subcellular Localization
Protein Description Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate..
Protein Sequence MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAGMLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLLSRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATARSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVDKMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEVFGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPPPGSPPQALAFPEHGSVYEYRRAQEAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
61SulfoxidationILEQEAGMLLPRDQP
HHHHHCCCCCCCCCC		4.4721406390
76PhosphorylationLDSSHIASIRMGTTV
CCCCCEEEECCCCCH		15.3224719451
81PhosphorylationIASIRMGTTVATNAL
EEEECCCCCHHHHHH		14.57-
82PhosphorylationASIRMGTTVATNALL
EEECCCCCHHHHHHH		11.47-
149PhosphorylationLHRGEAGTGTPVKGR
EECCCCCCCCCCCCC		44.9528450419
151PhosphorylationRGEAGTGTPVKGRTG
CCCCCCCCCCCCCCC		25.4228176443
154UbiquitinationAGTGTPVKGRTGDLL
CCCCCCCCCCCCCCE		43.8324816145
250UbiquitinationPAIQRYVQGFCRGFQ
HHHHHHHHHHHCHHC		30.2524816145
385UbiquitinationPGPACYRKGGPVTVT
CCCCCCCCCCCEEEC		41.57-
419PhosphorylationPGENQPLSPEASRKA
CCCCCCCCHHHHHHH		27.6425693802
423PhosphorylationQPLSPEASRKALEAV
CCCCHHHHHHHHHHH		32.4327050516
570PhosphorylationQAQGFPRSQISTESF
HHCCCCHHHCCCCCE		31.9120068231
576PhosphorylationRSQISTESFLHLRYQ
HHHCCCCCEEEEEEC		32.9520068231
639PhosphorylationDDVRVRGTGRSGLRL
EEEEECCCCCCCCCC		20.8924719451
642PhosphorylationRVRGTGRSGLRLEDA
EECCCCCCCCCCCCC		43.4524719451
654PhosphorylationEDAPKAQTGPPRVDK
CCCCCCCCCCCCCCC		57.4224719451
763PhosphorylationLQRTAISTNIKERLD
HHHHHHCCCHHHHCC		34.5521712546
883PhosphorylationQEGAVFLSFKLVQGG
CCCCEEEEEEEEECC		14.6324719451
906UbiquitinationEALRAPGKVPNCSGT
HHHHCCCCCCCCCCC		54.1629967540
921PhosphorylationRNLHDNLSDLRAQVA
CCCCCCHHHHHHHHH		40.6324719451
1003PhosphorylationIRLRVQISLSQGSAV
EEEEEEEEECCCCEE		12.6027251275
1005PhosphorylationLRVQISLSQGSAVFD
EEEEEEECCCCEEEE		26.2127251275
1008PhosphorylationQISLSQGSAVFDFSG
EEEECCCCEEEEECC		17.3927251275
1014PhosphorylationGSAVFDFSGTGPEVF
CCEEEEECCCCCHHC		36.9727251275
1037PhosphorylationVTLSALIYCLRCLVG
HHHHHHHHHHHHHHC		6.0520068231
1065PhosphorylationRVVIPRGSILDPSPE
EEEEECCCCCCCCCC		22.6620068231
1070PhosphorylationRGSILDPSPEAAVVG
CCCCCCCCCCCEEEC		34.7320068231
1082PhosphorylationVVGGNVLTSQRVVDV
EECCCCCCCHHHHHH		20.6620068231
1083PhosphorylationVGGNVLTSQRVVDVI
ECCCCCCCHHHHHHH		16.3020068231
1100PhosphorylationAFGACAASQGCMNNV
HHHHHHHCCCCCCCC		14.4720068231
1108PhosphorylationQGCMNNVTLGNAHMG
CCCCCCCEECCCCCE		30.9520068231
1116PhosphorylationLGNAHMGYYETVAGG
ECCCCCEEEECCCCC		7.2020068231
1117PhosphorylationGNAHMGYYETVAGGA
CCCCCEEEECCCCCC		10.2120068231
1119PhosphorylationAHMGYYETVAGGAGA
CCCEEEECCCCCCCC		10.2620068231
1129PhosphorylationGGAGAGPSWHGRSGV
CCCCCCCCCCCCCCC		30.6820068231
1146O-linked_GlycosylationHMTNTRITDPEILES
CCCCCCCCCHHHHHH		42.0630620550
1222AcetylationGLNLLIRKNGRTVNL
HHCEEEEECCEEEEC		57.687672005
1232AcetylationRTVNLGGKTSVTVYP
EEEECCCEEEEEECC		35.517672015
1265PhosphorylationDPAPPPGSPPQALAF
CCCCCCCCCCCCCCC		38.9026074081
1279PhosphorylationFPEHGSVYEYRRAQE
CCCCCCHHHHHHHHH		14.6726091039
1281PhosphorylationEHGSVYEYRRAQEAV
CCCCHHHHHHHHHCC		6.4226091039
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OPLA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPLA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPLA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of OPLA_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
2600055-oxoprolinase deficiency (OPLAHD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPLA_HUMAN

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Related Literatures of Post-Translational Modification

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