F162A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F162A_HUMAN
• UniProt AC: Q96A26
• Protein Name: Protein FAM162A
• Gene Name: FAM162A
• Organism: Homo sapiens (Human).
• Sequence Length: 154
• Subcellular Localization: Membrane ; Single-pass membrane protein . Mitochondrion .
• Protein Description: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly..
• Protein Sequence: MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPLHKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAKTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSLSGLRLA -----CCCCHHHHHH	20.33	24043423
5	Phosphorylation	---MGSLSGLRLAAG ---CCCCHHHHHHHC	37.16	24719451
13	Phosphorylation	GLRLAAGSCFRLCER HHHHHHCHHHHHHHC	12.83	24719451
47	Phosphorylation	FCTKPQESPGAPSRT CCCCCCCCCCCCCCC	24.32	25849741
62	Acetylation	YNRVPLHKPTDWQKK CCCCCCCCCCCHHHH	58.24	25953088
62	Malonylation	YNRVPLHKPTDWQKK CCCCCCCCCCCHHHH	58.24	26320211
62	Ubiquitination	YNRVPLHKPTDWQKK CCCCCCCCCCCHHHH	58.24	-
64	Phosphorylation	RVPLHKPTDWQKKIL CCCCCCCCCHHHHEE	55.46	24719451
68	2-Hydroxyisobutyrylation	HKPTDWQKKILIWSG CCCCCHHHHEEEEEC	37.21	-
69	2-Hydroxyisobutyrylation	KPTDWQKKILIWSGR CCCCHHHHEEEEECC	27.87	-
74	Phosphorylation	QKKILIWSGRFKKED HHHEEEEECCCCCCC	17.07	-
79	Ubiquitination	IWSGRFKKEDEIPET EEECCCCCCCCCCCC	68.62	21906983
91	Sulfoxidation	PETVSLEMLDAAKNK CCCEEHHHHHHHCHH	5.07	28465586
96	2-Hydroxyisobutyrylation	LEMLDAAKNKMRVKI HHHHHHHCHHHHHHH	59.84	-
96	Ubiquitination	LEMLDAAKNKMRVKI HHHHHHHCHHHHHHH	59.84	21906983
98	Ubiquitination	MLDAAKNKMRVKISY HHHHHCHHHHHHHHH	27.63	983
131	Phosphorylation	KAAQRHETLTSLNLE HHHHHHHHHHHCCHH	29.25	28122231
133	Phosphorylation	AQRHETLTSLNLEKK HHHHHHHHHCCHHHH	38.29	28122231
134	Phosphorylation	QRHETLTSLNLEKKA HHHHHHHHCCHHHHH	20.55	24719451
139	2-Hydroxyisobutyrylation	LTSLNLEKKARLKEE HHHCCHHHHHHHHHH	55.70	-
139	Ubiquitination	LTSLNLEKKARLKEE HHHCCHHHHHHHHHH	55.70	21906983
139	Malonylation	LTSLNLEKKARLKEE HHHCCHHHHHHHHHH	55.70	32601280
140	Ubiquitination	TSLNLEKKARLKEEA HHCCHHHHHHHHHHH	29.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F162A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F162A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F162A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRRT_HUMAN	SRRT	physical	22939629
TXTP_HUMAN	SLC25A1	physical	22939629
CAVN1_HUMAN	PTRF	physical	22939629
VDAC2_HUMAN	VDAC2	physical	22939629
RM22_HUMAN	MRPL22	physical	22939629
RMD3_HUMAN	RMDN3	physical	22939629
TM9S4_HUMAN	TM9SF4	physical	22939629
SSRG_HUMAN	SSR3	physical	22939629
HACL1_HUMAN	HACL1	physical	22939629
IWS1_HUMAN	IWS1	physical	22939629
HS90A_HUMAN	HSP90AA1	physical	16698020

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.