GALT7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALT7_HUMAN
• UniProt AC: Q86SF2
• Protein Name: N-acetylgalactosaminyltransferase 7
• Gene Name: GALNT7
• Organism: Homo sapiens (Human).
• Sequence Length: 657
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified..
• Protein Sequence: MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	O-linked_Glycosylation	VVLWSSLTPRPDDPS HHHHHCCCCCCCCCC	21.14	OGP
36	Phosphorylation	TPRPDDPSPLSRMRE CCCCCCCCHHHHCCC	45.53	21406692
39	Phosphorylation	PDDPSPLSRMREDRD CCCCCHHHHCCCCCC	27.67	21406692
103	Phosphorylation	EHHAGGDSQKDIMQR CCCCCCCCHHHHHHH	42.26	29255136
114	O-linked_Glycosylation	IMQRQYLTFKPQTFT HHHHHHEEECCCEEE	25.36	OGP
119	O-linked_Glycosylation	YLTFKPQTFTYHDPV HEEECCCEEEECCCC	26.86	OGP
121	O-linked_Glycosylation	TFKPQTFTYHDPVLR EECCCEEEECCCCCC	24.27	OGP
154	Ubiquitination	GGPGEKAKPLVLGPE CCCCCCCCCCEECHH	50.37	-
180	Phosphorylation	FGFNMVASDMISLDR HCCCCHHHHHHCCCC	19.12	22210691
232	2-Hydroxyisobutyrylation	RTVHSVIKRTPRKYL HHHHHHHHHCCHHHH	48.33	-
257	Ubiquitination	NKEHLKEKLDEYIKL CHHHHHHHHHHHHHH	60.70	29967540
270	Acetylation	KLWNGLVKVFRNERR HHHHHHHHHHHHHCC	40.47	88327
368	Phosphorylation	LWKRVPLTPQEKRLR HHHHCCCCHHHHHHH	19.49	-
372	Acetylation	VPLTPQEKRLRKTKT CCCCHHHHHHHCCCC	52.03	30588873
372	2-Hydroxyisobutyrylation	VPLTPQEKRLRKTKT CCCCHHHHHHHCCCC	52.03	-
372	Ubiquitination	VPLTPQEKRLRKTKT CCCCHHHHHHHCCCC	52.03	29967540
422	Ubiquitination	ENFEISYKIWQCGGK CCCEEEEEEEEECCE	30.58	21963094
442	Phosphorylation	CSRVGHIYRLEGWQG CCCCCEEEEECCCCC	11.94	20068231
447	Ubiquitination	HIYRLEGWQGNPPPI EEEEECCCCCCCCCE	8.11	21963094
459	Phosphorylation	PPIYVGSSPTLKNYV CCEEECCCHHHHHCE	18.90	-
461	Phosphorylation	IYVGSSPTLKNYVRV EEECCCHHHHHCEEE	52.92	-
463	Ubiquitination	VGSSPTLKNYVRVVE ECCCHHHHHCEEEEE	49.03	21963094
476	Phosphorylation	VEVWWDEYKDYFYAS EEEEHHHHHHHEEEC	13.49	-
479	Phosphorylation	WWDEYKDYFYASRPE EHHHHHHHEEECCCH	8.37	-
483	O-linked_Glycosylation	YKDYFYASRPESQAL HHHHEEECCCHHHCC	36.67	OGP
499	Ubiquitination	YGDISELKKFREDHN CCCHHHHHHHHHHCC	45.90	29967540
508	Ubiquitination	FREDHNCKSFKWFME HHHHCCCCCHHHHHH	65.33	-
519	Phosphorylation	WFMEEIAYDITSHYP HHHHHHHHHHHCCCC	17.34	20068231
522	Phosphorylation	EEIAYDITSHYPLPP HHHHHHHHCCCCCCC	13.42	20068231
523	Phosphorylation	EIAYDITSHYPLPPK HHHHHHHCCCCCCCC	22.74	27251275
525	Phosphorylation	AYDITSHYPLPPKNV HHHHHCCCCCCCCCC	13.26	20068231
544	Phosphorylation	IRGFETAYCIDSMGK CCCEEEEEEECCCCC	9.43	-
547	Ubiquitination	FETAYCIDSMGKTNG EEEEEEECCCCCCCC	29.07	21963094
572	Ubiquitination	MGGNQLFRINEANQL CCCCEEEEECHHHHH	39.14	21963094
588	Ubiquitination	QYDQCLTKGADGSKV CHHHHHCCCCCCCEE	38.87	21963094
622	Phosphorylation	HRFTHIPSGKCLDRS HHCCCCCCCCCCCHH	50.73	24719451
624	Ubiquitination	FTHIPSGKCLDRSEV CCCCCCCCCCCHHHH	35.64	-
638	Phosphorylation	VLHQVFISNCDSSKT HHHHHHHHCCCCCCC	21.68	23312004
642	Phosphorylation	VFISNCDSSKTTQKW HHHHCCCCCCCCCEE	35.61	23312004
643	Phosphorylation	FISNCDSSKTTQKWE HHHCCCCCCCCCEEE	22.29	23312004
648	Ubiquitination	DSSKTTQKWEMNNIH CCCCCCCEEECCCCC	42.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALT7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALT7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALT7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK06_HUMAN	MAPK6	physical	21988832
SL9A1_HUMAN	SLC9A1	physical	28514442
GLT12_HUMAN	GALNT12	physical	28514442
MA2A2_HUMAN	MAN2A2	physical	28514442
GALT4_HUMAN	GALNT4	physical	28514442
LYAG_HUMAN	GAA	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.