GLT12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLT12_HUMAN
• UniProt AC: Q8IXK2
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 12
• Gene Name: GALNT12
• Organism: Homo sapiens (Human).
• Sequence Length: 581
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs..
• Protein Sequence: MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Ubiquitination	IYLSDRISLHRRLPE EEECCCCCHHHCCHH	21.01	24816145
122	Ubiquitination	RRLPERWNPLCKEKK HCCHHHCCHHHHCCC	26.36	24816145
126	Ubiquitination	ERWNPLCKEKKYDYD HHCCHHHHCCCCCCC	79.03	-
128	Ubiquitination	WNPLCKEKKYDYDNL CCHHHHCCCCCCCCC	41.97	-
129	Ubiquitination	NPLCKEKKYDYDNLP CHHHHCCCCCCCCCC	44.43	-
196	Ubiquitination	NELSGLPKVRLIRAN HHHCCCCHHEEEECC	45.06	24816145
300	Phosphorylation	RERIRMQSPVDVIRS HHHHCCCCCCCCCCC	19.97	29083192
307	Phosphorylation	SPVDVIRSPTMAGGL CCCCCCCCCCCCCCH	17.38	24719451
309	Phosphorylation	VDVIRSPTMAGGLFA CCCCCCCCCCCCHHH	22.39	24719451
318	Phosphorylation	AGGLFAVSKKYFEYL CCCHHHCCHHHHHHH	21.72	29083192
320	Ubiquitination	GLFAVSKKYFEYLGS CHHHCCHHHHHHHCC	47.90	-
343	Phosphorylation	GGENLEFSFRIWQCG CCCCCEEEEEEEEEC	12.30	24719451
375	Ubiquitination	QAPYSRNKALANSVR CCCCCHHHHHHHHHH	43.60	29967540
544	Phosphorylation	GSLFHEQSKKCVQAA CCCCHHHHHHHHHHH	30.97	25247763
555	Phosphorylation	VQAARKESSDSFVPL HHHHHHHCCCCCHHH	42.34	26657352
556	Phosphorylation	QAARKESSDSFVPLL HHHHHHCCCCCHHHH	38.06	27486199
558	Phosphorylation	ARKESSDSFVPLLRD HHHHCCCCCHHHHHH	30.05	27486199

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLT12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLT12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLT12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUC1_HUMAN	MUC1	physical	12135769
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.