| UniProt ID | MA2A2_HUMAN | |
|---|---|---|
| UniProt AC | P49641 | |
| Protein Name | Alpha-mannosidase 2x | |
| Gene Name | MAN2A2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1150 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein. |
|
| Protein Description | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.. | |
| Protein Sequence | MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFALGGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPMEIATFRLRLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | O-linked_Glycosylation | NGGNFPRSQISVLQN CCCCCCHHHHHHHHH | 31.91 | OGP | |
| 95 | N-linked_Glycosylation | MLPYYTVNGSWVVPP CCCEEEECCEEECCC | 30.86 | UniProtKB CARBOHYD | |
| 107 | O-linked_Glycosylation | VPPEPRPSFFSISPQ CCCCCCCCCEECCHH | 39.96 | OGP | |
| 305 | N-linked_Glycosylation | PYLLRRANLTSMLIQ HHHHHHCCHHHHHHH | 41.88 | UniProtKB CARBOHYD | |
| 307 | Phosphorylation | LLRRANLTSMLIQRV HHHHCCHHHHHHHHH | 16.34 | 26074081 | |
| 308 | Phosphorylation | LRRANLTSMLIQRVH HHHCCHHHHHHHHHH | 18.11 | 26074081 | |
| 316 | Phosphorylation | MLIQRVHYAIKKHFA HHHHHHHHHHHHHHH | 13.73 | 26074081 | |
| 325 | Phosphorylation | IKKHFAATHSLEFMW HHHHHHEEECEEEEE | 14.47 | 26074081 | |
| 327 | Phosphorylation | KHFAATHSLEFMWRQ HHHHEEECEEEEEEC | 25.82 | 26074081 | |
| 373 | Acetylation | ICCQFDFKRLPGGRI EEEEECCCCCCCCCC | 55.67 | 27452117 | |
| 490 | Phosphorylation | PPGFPVLSGDFFSYA CCCCCEECCCCCCCC | 36.23 | 22210691 | |
| 495 | Phosphorylation | VLSGDFFSYADREDH EECCCCCCCCCCCCC | 21.29 | 22210691 | |
| 496 | Phosphorylation | LSGDFFSYADREDHY ECCCCCCCCCCCCCC | 13.83 | 22210691 | |
| 516 | O-linked_Glycosylation | TSRPFYKSLDRVLEA CCCHHHHCHHHHHHH | 24.91 | 29351928 | |
| 639 | Phosphorylation | HDALPERTVIQLDSS CCCCCCCEEEECCCC | 21.94 | 28857561 | |
| 646 | Phosphorylation | TVIQLDSSPRFVVLF EEEECCCCCCEEEEE | 21.55 | 28857561 | |
| 662 | Phosphorylation | PLEQERFSMVSLLVN HHCCHHCCHHHHHHC | 25.21 | 29449344 | |
| 665 | Phosphorylation | QERFSMVSLLVNSPR CHHCCHHHHHHCCCC | 13.82 | 26029660 | |
| 670 | Phosphorylation | MVSLLVNSPRVRVLS HHHHHHCCCCEEEEC | 13.45 | 26029660 | |
| 744 | Phosphorylation | YLHGRQLSVSRHEAF EECCEEEEECCCCCC | 15.09 | 24719451 | |
| 769 | Phosphorylation | DFALSNRYMQVWFSG CCHHCCHHHHHHHHH | 8.99 | - | |
| 783 | Phosphorylation | GLTGLLKSIRRVDEE HHHHHHHHHHCCCHH | 22.69 | - | |
| 823 (in isoform 1) | Phosphorylation | - | 32.36 | 23186163 | |
| 825 | Phosphorylation | PDGEAKPYVPKEPPV CCCCCCCCCCCCCCE | 28.78 | 22210691 | |
| 825 (in isoform 1) | Phosphorylation | - | 28.78 | 23186163 | |
| 826 (in isoform 1) | Phosphorylation | - | 8.08 | - | |
| 850 (in isoform 1) | Phosphorylation | - | 13.50 | - | |
| 852 (in isoform 1) | Phosphorylation | - | 16.08 | - | |
| 923 | Phosphorylation | LPLQANFYPMPVMAY CCCCCCCCCCCHHHH | 9.83 | 19835603 | |
| 939 | Phosphorylation | QDAQKRLTLHTAQAL HHHHHHHHHHHHHHH | 22.11 | - | |
| 1093 | N-linked_Glycosylation | EAKNLGFNCTTSQGK CCCCCCCEEECCCCC | 22.04 | 17660510 | |
| 1131 | N-linked_Glycosylation | YPLASPSNSTDVYLE EECCCCCCCCCEEEC | 52.92 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MA2A2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MA2A2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MA2A2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GIT1_HUMAN | GIT1 | physical | 16169070 | |
| ELP1_HUMAN | IKBKAP | physical | 16169070 | |
| LC7L2_HUMAN | LUC7L2 | physical | 16169070 | |
| CHD3_HUMAN | CHD3 | physical | 16169070 | |
| VIME_HUMAN | VIM | physical | 16169070 | |
| CAN2_HUMAN | CAPN2 | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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