PLD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLD6_HUMAN
• UniProt AC: Q8N2A8
• Protein Name: Mitochondrial cardiolipin hydrolase
• Gene Name: PLD6
• Organism: Homo sapiens (Human).
• Sequence Length: 252
• Subcellular Localization: Mitochondrion outer membrane ; Single-pass membrane protein .
• Protein Description: Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low. [PubMed: 21397848 In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol]
• Protein Sequence: MGRLSWQVAAAAAVGLALTLEALPWVLRWLRSRRRRPRREALFFPSQVTCTEALLRAPGAELAELPEGCPCGLPHGESALSRLLRALLAARASLDLCLFAFSSPQLGRAVQLLHQRGVRVRVVTDCDYMALNGSQIGLLRKAGIQVRHDQDPGYMHHKFAIVDKRVLITGSLNWTTQAIQNNRENVLITEDDEYVRLFLEEFERIWEQFNPTKYTFFPPKKSHGSCAPPVSRAGGRLLSWHRTCGTSSESQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
124	Phosphorylation	GVRVRVVTDCDYMAL CCEEEEEECCCEEEC	28.22	-
158	Ubiquitination	DPGYMHHKFAIVDKR CCCCCCEEEEEECCE	23.08	22817900
221	Ubiquitination	YTFFPPKKSHGSCAP CEECCCCCCCCCCCC	54.16	29967540
225	Phosphorylation	PPKKSHGSCAPPVSR CCCCCCCCCCCCCCC	11.15	22964224
231	Phosphorylation	GSCAPPVSRAGGRLL CCCCCCCCCCCCCEE	23.37	22964224
239	Phosphorylation	RAGGRLLSWHRTCGT CCCCCEEEEECCCCC	25.98	24719451
243	Phosphorylation	RLLSWHRTCGTSSES CEEEEECCCCCCCCC	11.47	24144214
246	Phosphorylation	SWHRTCGTSSESQT- EEECCCCCCCCCCC-	31.09	24144214
247	Phosphorylation	WHRTCGTSSESQT-- EECCCCCCCCCCC--	19.86	24144214
248	Phosphorylation	HRTCGTSSESQT--- ECCCCCCCCCCC---	40.90	24144214
250	Phosphorylation	TCGTSSESQT----- CCCCCCCCCC-----	40.86	24144214
252	Phosphorylation	GTSSESQT------- CCCCCCCC-------	50.27	24144214

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLD6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLD6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLD6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.