IGSF3_HUMAN - dbPTM
IGSF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IGSF3_HUMAN
UniProt AC O75054
Protein Name Immunoglobulin superfamily member 3
Gene Name IGSF3
Organism Homo sapiens (Human).
Sequence Length 1194
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description
Protein Sequence MKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTMDSSFPYAIYTQRVRGGKIFIERVQGNSTLLHITDLQARDAGEYECHTPSTDKQYFGSYSAKMNLVVIPDSLQTTAMPQTLHRVEQDPLELTCEVASETIQHSHLSVAWLRQKVGEKPVEVISLSRDFMLHSSSEYAQRQSLGEVRLDKLGRTTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETEKRLHTVGEPVEFRCILEAQNVPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREARGQLKVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIIVLPLKSSISVEVASNASVILEGEDLRFSCSVRTAGRPQGRFSVIWQLVDRQNRRSNIMWLDRDGTVQPGSSYWERSSFGGVQMEQVQPNSFSLGIFNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTPISITALEMGFAVTAISRTPGVTYSDSFDLQCIIKPHYPAWVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRKNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENKPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLRLSQAQGNLSVLETRQVQLECVVLNRTSITSQLMVEWFVWKPNHPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHVEEWLPSPSGMWYKRAEDTAGQTALTVMRPDASLQVDTVVPNATVSEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRSSPGLEEQEEEREEEEEEDDDDDDDPTERTALLSVGPDAVFGPEGSPWEGRLRFQRLSPVLYRLTVLQASPQDTGNYSCHVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSPTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSDGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43N-linked_GlycosylationSHITIWCNVSGYQGP
CEEEEEEECCCCCCC		18.92UniProtKB CARBOHYD
197PhosphorylationEKPVEVISLSRDFML
CCCEEEEEECCCCCC		26.0124719451
199PhosphorylationPVEVISLSRDFMLHS
CEEEEEECCCCCCCC		24.02-
227PhosphorylationRLDKLGRTTFRLTIF
CHHHHCCEEEEEEEE		28.6124732914
228PhosphorylationLDKLGRTTFRLTIFH
HHHHCCEEEEEEEEE		12.8524732914
267PhosphorylationYAMTRKRSEGAVVNV
EEEEECCCCCCEEEE		43.3426546556
282PhosphorylationQPTDKEFTVRLETEK
CCCCCCEEEEEEECC		13.0520736484
293PhosphorylationETEKRLHTVGEPVEF
EECCCEEECCCCEEE		34.4920736484
374PhosphorylationRQEDSGKYNCRVTER
CHHHCCCEEEEEEEC		24.0324719451
379PhosphorylationGKYNCRVTEREKTVT
CCEEEEEEECEEEEC		15.2426074081
384PhosphorylationRVTEREKTVTGEFID
EEEECEEEECCEECC		20.6726074081
386PhosphorylationTEREKTVTGEFIDKE
EECEEEECCEECCCC		35.9024719451
394PhosphorylationGEFIDKESKRPKNIP
CEECCCCCCCCCCCC		39.4426074081
418N-linked_GlycosylationISVEVASNASVILEG
EEEEEECCCEEEECC		26.88UniProtKB CARBOHYD
548PhosphorylationLEMGFAVTAISRTPG
EECCEEEEEEECCCC		18.1626074081
551PhosphorylationGFAVTAISRTPGVTY
CEEEEEEECCCCCCC		27.8626074081
553PhosphorylationAVTAISRTPGVTYSD
EEEEEECCCCCCCCC		20.0126074081
557PhosphorylationISRTPGVTYSDSFDL
EECCCCCCCCCCEEE		24.1926074081
558PhosphorylationSRTPGVTYSDSFDLQ
ECCCCCCCCCCEEEE		14.2026074081
610PhosphorylationGVQWGDRSSSFRTRT
CCCCCCCCCCCCCCH		34.7723312004
611PhosphorylationVQWGDRSSSFRTRTA
CCCCCCCCCCCCCHH		34.1023312004
612PhosphorylationQWGDRSSSFRTRTAI
CCCCCCCCCCCCHHH		21.7223312004
615PhosphorylationDRSSSFRTRTAIEKA
CCCCCCCCCHHHHHH		30.2923312004
617PhosphorylationSSSFRTRTAIEKAES
CCCCCCCHHHHHHHH		31.2330619164
624PhosphorylationTAIEKAESSNNVRLS
HHHHHHHHCCCEEEE		43.1330619164
625PhosphorylationAIEKAESSNNVRLSI
HHHHHHHCCCEEEEE		24.7530576142
631PhosphorylationSSNNVRLSISRASDT
HCCCEEEEEECCCCC		14.1424719451
651PhosphorylationQCVAELWRKNYNNTW
HHHHHHHHHHCCCHH		29.9324719451
655N-linked_GlycosylationELWRKNYNNTWTRLA
HHHHHHCCCHHHHHH		49.18UniProtKB CARBOHYD
657PhosphorylationWRKNYNNTWTRLAER
HHHHCCCHHHHHHHH		25.2822468782
659PhosphorylationKNYNNTWTRLAERTS
HHCCCHHHHHHHHHC		17.4822468782
665PhosphorylationWTRLAERTSNLLEIR
HHHHHHHHCCCEEEE		17.3022468782
678PhosphorylationIRVLQPVTKLQVSKS
EEEEECCCEEEECCC		32.49-
702PhosphorylationKPIQLNCSVKSQTSQ
CCEEEEEEEEECCCC		31.3520068231
733PhosphorylationDGKLILKTTHNSAFE
CCCEEEEECCCCHHH		29.8220068231
734PhosphorylationGKLILKTTHNSAFEY
CCEEEEECCCCHHHC		19.9220068231
761PhosphorylationLQFERHVSGGLFSLT
EEEEEECCCCEEEEE		22.4826074081
766PhosphorylationHVSGGLFSLTVQRAE
ECCCCEEEEEEEEEE		28.3326074081
768PhosphorylationSGGLFSLTVQRAEVS
CCCEEEEEEEEEEEC		17.2526074081
775PhosphorylationTVQRAEVSDSGSYYC
EEEEEEECCCCCEEE		19.9826074081
777PhosphorylationQRAEVSDSGSYYCHV
EEEEECCCCCEEEEE		23.3326074081
779PhosphorylationAEVSDSGSYYCHVEE
EEECCCCCEEEEEEE		19.5126074081
780PhosphorylationEVSDSGSYYCHVEEW
EECCCCCEEEEEEEE		17.4026074081
781PhosphorylationVSDSGSYYCHVEEWL
ECCCCCEEEEEEEEE		4.2724719451
825N-linked_GlycosylationRLSQAQGNLSVLETR
EEEHHCCCCEEEEEE		19.6419349973
825N-linked_GlycosylationRLSQAQGNLSVLETR
EEEHHCCCCEEEEEE		19.64-
842N-linked_GlycosylationQLECVVLNRTSITSQ
EEEEEEECCCCCCEE		33.31UniProtKB CARBOHYD
895PhosphorylationKGRLHLESPSPGVYR
CCCEEECCCCCCEEE		36.7220068231
897PhosphorylationRLHLESPSPGVYRLF
CEEECCCCCCEEEEE		43.49-
991PhosphorylationSRFAVAWYSLRTKAG
CCEEEEHHHEECCCC		6.52-
992PhosphorylationRFAVAWYSLRTKAGG
CEEEEHHHEECCCCC		10.7324719451
1012PhosphorylationGLEEQEEEREEEEEE
CHHHHHHHHHHHHHC		65.7224719451
1077N-linked_GlycosylationASPQDTGNYSCHVEE
CCCCCCCCCEEEEEE		27.86UniProtKB CARBOHYD
1158PhosphorylationSRNSSKNSDGKNGVP
CCCCCCCCCCCCCCE		52.0224275748
1161UbiquitinationSSKNSDGKNGVPLLW
CCCCCCCCCCCEEEE		56.3633845483
1176PhosphorylationIKEPHLNYSPTCLEP
EECCCCCCCCCCCCC		23.5330108239
1177PhosphorylationKEPHLNYSPTCLEPP
ECCCCCCCCCCCCCC		16.8027794612
1179PhosphorylationPHLNYSPTCLEPPVL
CCCCCCCCCCCCCEE		24.6327794612
1181UbiquitinationLNYSPTCLEPPVLSI
CCCCCCCCCCCEEEE		14.0733845483
1187PhosphorylationCLEPPVLSIHPGAID
CCCCCEEEECCCCCC		21.0526356563
1196PhosphorylationHPGAID---------
CCCCCC---------		27642862
1197PhosphorylationPGAID----------
CCCCC----------		27642862
1199PhosphorylationAID------------
CCC------------		24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IGSF3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IGSF3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IGSF3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of IGSF3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
149700Lacrimal duct defect (LCDD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IGSF3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-617 AND SER-625, ANDMASS SPECTROMETRY.

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