TSN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSN3_HUMAN
• UniProt AC: O60637
• Protein Name: Tetraspanin-3
• Gene Name: TSPAN3
• Organism: Homo sapiens (Human).
• Sequence Length: 253
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair..
• Protein Sequence: MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGTYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GQCGITSSKTVLVFL CCCCCCCCHHHHHHH	24.56	22210691
57	Ubiquitination	TLIPAVVIIAVGALL HHHHHHHHHHHHHHH	1.03	21963094
60	Ubiquitination	PAVVIIAVGALLFII HHHHHHHHHHHHHHH	3.04	21963094
82	Ubiquitination	TIRESRCGLATFVII HHHHHHHHHHHHHHH	19.75	21963094
85	Ubiquitination	ESRCGLATFVIILLL HHHHHHHHHHHHHHH	24.39	21963094
96	Ubiquitination	ILLLVFVTEVVVVVL HHHHHHHHHHHHHHH	16.17	21963094
99	Ubiquitination	LVFVTEVVVVVLGYV HHHHHHHHHHHHHHH	1.89	21963094
102	Ubiquitination	VTEVVVVVLGYVYRA HHHHHHHHHHHHHHH	2.01	21963094
110	Ubiquitination	LGYVYRAKVENEVDR HHHHHHHHHCCHHHH	40.87	-
121	2-Hydroxyisobutyrylation	EVDRSIQKVYKTYNG HHHHHHHHHHHHHCC	45.95	-
121	Ubiquitination	EVDRSIQKVYKTYNG HHHHHHHHHHHHHCC	45.95	21963094
124	Ubiquitination	RSIQKVYKTYNGTNP HHHHHHHHHHCCCCH	47.74	21906983
125	Phosphorylation	SIQKVYKTYNGTNPD HHHHHHHHHCCCCHH	12.44	-
126	Phosphorylation	IQKVYKTYNGTNPDA HHHHHHHHCCCCHHH	13.87	-
127	N-linked_Glycosylation	QKVYKTYNGTNPDAA HHHHHHHCCCCHHHH	56.92	UniProtKB CARBOHYD
127	Ubiquitination	QKVYKTYNGTNPDAA HHHHHHHCCCCHHHH	56.92	21963094
129	Phosphorylation	VYKTYNGTNPDAASR HHHHHCCCCHHHHHH	39.68	-
138	Ubiquitination	PDAASRAIDYVQRQL HHHHHHHHHHHHHHH	3.69	22817900
141	Ubiquitination	ASRAIDYVQRQLHCC HHHHHHHHHHHHCCC	3.16	21963094
152	N-linked_Glycosylation	LHCCGIHNYSDWENT HCCCCCCCCCCCCCC	35.76	UniProtKB CARBOHYD
163	Ubiquitination	WENTDWFKETKNQSV CCCCHHHHHCCCCCC	61.29	22817900
166	Ubiquitination	TDWFKETKNQSVPLS CHHHHHCCCCCCCHH	54.82	21963094
167	N-linked_Glycosylation	DWFKETKNQSVPLSC HHHHHCCCCCCCHHH	46.94	UniProtKB CARBOHYD
169	Phosphorylation	FKETKNQSVPLSCCR HHHCCCCCCCHHHHH	34.79	-
173	Phosphorylation	KNQSVPLSCCRETAS CCCCCCHHHHHHCHH	12.71	-
183	N-linked_Glycosylation	RETASNCNGSLAHPS HHCHHCCCCCCCCHH	47.54	UniProtKB CARBOHYD
185	Phosphorylation	TASNCNGSLAHPSDL CHHCCCCCCCCHHHH	14.37	-
238	Phosphorylation	CIVLCRRSRDPAYEL HHHHHHCCCCCCHHH	22.99	28796482
243	Phosphorylation	RRSRDPAYELLITGG HCCCCCCHHHHHCCC	16.70	21082442
248	Phosphorylation	PAYELLITGGTYA-- CCHHHHHCCCCCC--	29.54	28857561
251	Phosphorylation	ELLITGGTYA----- HHHHCCCCCC-----	20.02	29978859
252	Phosphorylation	LLITGGTYA------ HHHCCCCCC------	17.37	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFIP2_HUMAN	NDFIP2	physical	26186194
NFIP1_HUMAN	NDFIP1	physical	26186194
NOTC3_HUMAN	NOTCH3	physical	26186194
CDC6_HUMAN	CDC6	physical	26186194
GBRAP_HUMAN	GABARAP	physical	26186194
STX6_HUMAN	STX6	physical	26186194
PLCC_HUMAN	AGPAT3	physical	26186194
SDCB1_HUMAN	SDCBP	physical	26186194
CD320_HUMAN	CD320	physical	26186194
KDSR_HUMAN	KDSR	physical	26186194
EPHA5_HUMAN	EPHA5	physical	26186194
EPHA4_HUMAN	EPHA4	physical	26186194
MP3B2_HUMAN	MAP1LC3B2	physical	26186194
RN149_HUMAN	RNF149	physical	26186194
C2D1A_HUMAN	CC2D1A	physical	26186194
FGFR1_HUMAN	FGFR1	physical	26186194
FGFR2_HUMAN	FGFR2	physical	26186194
TR10B_HUMAN	TNFRSF10B	physical	26186194
CEGT_HUMAN	UGCG	physical	26186194
GOGA7_HUMAN	GOLGA7	physical	26186194
SNX17_HUMAN	SNX17	physical	26186194
ZDHC9_HUMAN	ZDHHC9	physical	26186194
KC1G3_HUMAN	CSNK1G3	physical	26186194
INGR1_HUMAN	IFNGR1	physical	26186194
ACV1B_HUMAN	ACVR1B	physical	26186194
RDH14_HUMAN	RDH14	physical	26186194
P4K2A_HUMAN	PI4K2A	physical	26186194
CD63_HUMAN	CD63	physical	26186194
ARL17_HUMAN	ARL17A	physical	26186194
LRP10_HUMAN	LRP10	physical	26186194
C2D1A_HUMAN	CC2D1A	physical	28514442
P4K2A_HUMAN	PI4K2A	physical	28514442
CEGT_HUMAN	UGCG	physical	28514442
RDH14_HUMAN	RDH14	physical	28514442
EPHA5_HUMAN	EPHA5	physical	28514442
FGFR2_HUMAN	FGFR2	physical	28514442
GOGA7_HUMAN	GOLGA7	physical	28514442
NFIP1_HUMAN	NDFIP1	physical	28514442
STX6_HUMAN	STX6	physical	28514442
CD320_HUMAN	CD320	physical	28514442
TR10B_HUMAN	TNFRSF10B	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
CDC6_HUMAN	CDC6	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
MP3B2_HUMAN	MAP1LC3B2	physical	28514442
FGFR1_HUMAN	FGFR1	physical	28514442
NOTC3_HUMAN	NOTCH3	physical	28514442
EPHA4_HUMAN	EPHA4	physical	28514442
LMA2L_HUMAN	LMAN2L	physical	28514442
NFIP2_HUMAN	NDFIP2	physical	28514442
SNX17_HUMAN	SNX17	physical	28514442
PAQR1_HUMAN	ADIPOR1	physical	28514442
GBRAP_HUMAN	GABARAP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.