PAQR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAQR1_HUMAN
• UniProt AC: Q96A54
• Protein Name: Adiponectin receptor protein 1 {ECO:0000303|PubMed:12802337}
• Gene Name: ADIPOR1 {ECO:0000312|HGNC:HGNC:24040}
• Organism: Homo sapiens (Human).
• Sequence Length: 375
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Localized to the cell membrane and intracellular organelles.
• Protein Description: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. [PubMed: 25855295]
• Protein Sequence: MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDTLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSHKGSVV ------CCCCCCCCE		25002506
3	Phosphorylation	-----MSSHKGSVVA -----CCCCCCCCEE		25002506
7	Phosphorylation	-MSSHKGSVVAQGNG -CCCCCCCCEECCCC		80527403
18	Phosphorylation	QGNGAPASNREADTV CCCCCCCCCCCCCCE		24719451
24	Phosphorylation	ASNREADTVELAELG CCCCCCCCEEHHHHH		80527401
37	Ubiquitination	LGPLLEEKGKRVIAN HHHHHHHHCCEEECC		32015554
53	Phosphorylation	PKAEEEQTCPVPQEE CCCCHHCCCCCCHHH		80527405
68	Phosphorylation	EEEVRVLTLPLQAHH HHHHEEEECCHHHHH		28060719
79	Ubiquitination	QAHHAMEKMEEFVYK HHHHHHHHHHHHHHH		32015554
85	Phosphorylation	EKMEEFVYKVWEGRW HHHHHHHHHHHCCCC		25884760
86	Ubiquitination	KMEEFVYKVWEGRWR HHHHHHHHHHCCCCE		22817900
126	Ubiquitination	PSFRACFKSIFRIHT HHHHHHHHHHHCHHH		21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	S	Phosphorylation	Kinase	GRK2	P25098	PSP
24	T	Phosphorylation	Kinase	GRK2	P25098	PSP
53	T	Phosphorylation	Kinase	GRK2	P25098	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAQR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAQR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DP13A_HUMAN	APPL1	physical	16622416
NAA20_HUMAN	NAA20	physical	21988832
IKBL1_HUMAN	NFKBIL1	physical	21988832
DPH3_HUMAN	DPH3	physical	21988832
FA45A_HUMAN	FAM45A	physical	28514442
WFS1_HUMAN	WFS1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.