IKBL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKBL1_HUMAN
• UniProt AC: Q9UBC1
• Protein Name: NF-kappa-B inhibitor-like protein 1
• Gene Name: NFKBIL1
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Subcellular Localization: Nucleus . Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
• Protein Description: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli..
• Protein Sequence: MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEVMGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSCRPPRAEGSSQSWRQQEEEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELGRVMGAVTALSQALNRHAEALK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSNPSPQVP ------CCCCCCCCC	58.40	-
5	Phosphorylation	---MSNPSPQVPEEE ---CCCCCCCCCHHH	32.01	25159151
26	Phosphorylation	RPKSSMASTSRRQRR CCCCCCCCCHHHHHH	20.48	-
27	Phosphorylation	PKSSMASTSRRQRRE CCCCCCCCHHHHHHH	19.40	-
28	Phosphorylation	KSSMASTSRRQRRER CCCCCCCHHHHHHHH	23.99	-
150	Phosphorylation	GWGPPWDSAEEEEED CCCCCCCCHHHHHCC	33.44	30175587
160	Phosphorylation	EEEEDDASKEREWRQ HHHCCHHHHHHHHHH	41.88	29978859
212	Ubiquitination	LAREHAQKCQQQQRE HHHHHHHHHHHHHHH	34.49	-
253	Acetylation	FRERARAKEEELRES HHHHHHHHHHHHHHH	61.17	19818179
291	Methylation	EHPRGAGRGSLWRFG CCCCCCCCCCCCCCC	30.87	54557645
293	Phosphorylation	PRGAGRGSLWRFGDV CCCCCCCCCCCCCCC	24.33	24719451
352	Phosphorylation	RFLQRFRSQIETWEL HHHHHHHHHHHHHHH	32.56	27251275
367	Phosphorylation	GRVMGAVTALSQALN HHHHHHHHHHHHHHH	22.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKBL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKBL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKBL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GEMI4_HUMAN	GEMIN4	physical	17353931
RT22_HUMAN	MRPS22	physical	17353931
RFXK_HUMAN	RFXANK	physical	17353931
LUC7L_HUMAN	LUC7L	physical	17353931
PININ_HUMAN	PNN	physical	17353931
RT34_HUMAN	MRPS34	physical	17353931
RM44_HUMAN	MRPL44	physical	17353931
RT18B_HUMAN	MRPS18B	physical	17353931
K2C1B_HUMAN	KRT77	physical	17353931
CX056_HUMAN	CXorf56	physical	17353931

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 180300: Rheumatoid arthritis (RA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150, AND MASSSPECTROMETRY.
PubMed: 18691976