dbPTM

LUC7L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LUC7L_HUMAN
UniProt AC	Q9NQ29
Protein Name	Putative RNA-binding protein Luc7-like 1
Gene Name	LUC7L
Organism	Homo sapiens (Human).
Sequence Length	371
Subcellular Localization
Protein Description	May bind to RNA via its Arg/Ser-rich domain..
Protein Sequence	MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKLSRSRSRDRHRRHRSRSRSHSRGHRRASRDRSAKYKFSRERASREESWESGRSERGPPDWRLESSNGKMASRRSEEKEAGEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Sulfoxidation	RALLDQLMGTARDGD HHHHHHHHCCCCCCH	3.58	21406390
29	Acetylation	DETRQRVKFTDDRVC HHHHHHCCCCCCHHH	44.74	25953088
61	Acetylation	MDLGECTKIHDLALR CCHHHCCHHHHHHHH	50.10	26051181
61	Ubiquitination	MDLGECTKIHDLALR CCHHHCCHHHHHHHH	50.10	-
111	Phosphorylation	AKKRLAETQEEISAE HHHHHHHHHHHHHHH	35.36	17525332
125	Acetylation	EVSAKAEKVHELNEE HHHHHHHHHHHHHHH	54.47	25953088
135	Acetylation	ELNEEIGKLLAKAEQ HHHHHHHHHHHHHHH	46.09	25953088
135	Ubiquitination	ELNEEIGKLLAKAEQ HHHHHHHHHHHHHHH	46.09	-
139	Ubiquitination	EIGKLLAKAEQLGAE HHHHHHHHHHHHCCC	53.04	-
157	Sulfoxidation	DESQKILMEVEKVRA CHHHHHHHHHHHHHH	6.54	21406390
177	Sulfoxidation	EEEYRNSMPASSFQQ HHHHHHCCCCHHHHH	3.52	21406390
186	Sumoylation	ASSFQQQKLRVCEVC CHHHHHHHHHHHHHH	33.64	-
186	Malonylation	ASSFQQQKLRVCEVC CHHHHHHHHHHHHHH	33.64	26320211
186	Sumoylation	ASSFQQQKLRVCEVC CHHHHHHHHHHHHHH	33.64	-
186	Acetylation	ASSFQQQKLRVCEVC CHHHHHHHHHHHHHH	33.64	23749302
186	Ubiquitination	ASSFQQQKLRVCEVC CHHHHHHHHHHHHHH	33.64	-
213	Acetylation	LADHFGGKLHLGFIQ HHHHHCCCEEEHHHH	32.86	25953088
262	Phosphorylation	RLSRRSGSRTRDRRR HHHHHCCCHHHHHHH	31.55	-
270	Phosphorylation	RTRDRRRSRSRDRRR HHHHHHHHHHHHHHH	32.56	20068231
272	Phosphorylation	RDRRRSRSRDRRRRR HHHHHHHHHHHHHHH	39.52	20068231
280	Phosphorylation	RDRRRRRSRSTSRER HHHHHHHHHHHHHHH	28.86	30576142
282	Phosphorylation	RRRRRSRSTSRERRK HHHHHHHHHHHHHHH	31.79	30576142
283	Phosphorylation	RRRRSRSTSRERRKL HHHHHHHHHHHHHHH	30.60	30576142
284	Phosphorylation	RRRSRSTSRERRKLS HHHHHHHHHHHHHHH	33.13	30576142
293	Phosphorylation	ERRKLSRSRSRDRHR HHHHHHHHHHHHHHH	31.09	20068231
295	Phosphorylation	RKLSRSRSRDRHRRH HHHHHHHHHHHHHHH	39.52	20068231
304	Phosphorylation	DRHRRHRSRSRSHSR HHHHHHHHHHHHHHH	28.60	17081983
306	Phosphorylation	HRRHRSRSRSHSRGH HHHHHHHHHHHHHHC	39.11	17081983
327	Phosphorylation	RSAKYKFSRERASRE HHHHHHHHHHHHHHH	29.13	24719451
332	Phosphorylation	KFSRERASREESWES HHHHHHHHHHHHHHC	46.58	25159151
336	Phosphorylation	ERASREESWESGRSE HHHHHHHHHHCCCCC	31.24	23401153
339	Phosphorylation	SREESWESGRSERGP HHHHHHHCCCCCCCC	32.99	22167270
342	Phosphorylation	ESWESGRSERGPPDW HHHHCCCCCCCCCCC	34.86	23403867
353	Phosphorylation	PPDWRLESSNGKMAS CCCCCCCCCCCCCCC	33.42	26074081
354	Phosphorylation	PDWRLESSNGKMASR CCCCCCCCCCCCCCC	39.98	26074081
357	Acetylation	RLESSNGKMASRRSE CCCCCCCCCCCCCHH	35.23	25953088
360	Phosphorylation	SSNGKMASRRSEEKE CCCCCCCCCCHHCHH	25.40	30108239
363	Phosphorylation	GKMASRRSEEKEAGE CCCCCCCHHCHHCCC	49.34	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LUC7L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LUC7L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LUC7L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHERP_HUMAN	CHERP	physical	22365833
CTBL1_HUMAN	CTNNBL1	physical	22365833
LUC7L_HUMAN	LUC7L	physical	22365833
PRDX1_HUMAN	PRDX1	physical	21988832
ANM5_HUMAN	PRMT5	physical	23455924
LC7L2_HUMAN	LUC7L2	physical	26186194
RBM27_HUMAN	RBM27	physical	26186194
RBM26_HUMAN	RBM26	physical	26186194
ZFP91_HUMAN	ZFP91	physical	26186194
RM46_HUMAN	MRPL46	physical	26186194
EI2BA_HUMAN	EIF2B1	physical	26186194
ZCH18_HUMAN	ZC3H18	physical	26186194
NKAP_HUMAN	NKAP	physical	26186194
BCLF1_HUMAN	BCLAF1	physical	26186194
TR150_HUMAN	THRAP3	physical	26186194
RECQ4_HUMAN	RECQL4	physical	26186194
PRP4B_HUMAN	PRPF4B	physical	26186194
C1QBP_HUMAN	C1QBP	physical	26186194
SRPK1_HUMAN	SRPK1	physical	26186194
SRPK2_HUMAN	SRPK2	physical	26186194
SRRM2_HUMAN	SRRM2	physical	26186194
FXR1_HUMAN	FXR1	physical	26186194
PTCD3_HUMAN	PTCD3	physical	26186194
ZN638_HUMAN	ZNF638	physical	26186194
RBM23_HUMAN	RBM23	physical	26186194
GPTC8_HUMAN	GPATCH8	physical	26186194
RT27_HUMAN	MRPS27	physical	26186194
U2AF2_HUMAN	U2AF2	physical	26186194
NRDC_HUMAN	NRD1	physical	26186194
UBE2O_HUMAN	UBE2O	physical	26186194
LS14B_HUMAN	LSM14B	physical	26186194
SRRM1_HUMAN	SRRM1	physical	26186194
NEUA_HUMAN	CMAS	physical	26186194
PPIG_HUMAN	PPIG	physical	26186194
PININ_HUMAN	PNN	physical	26186194
VANG1_HUMAN	VANGL1	physical	26186194
ZCHC8_HUMAN	ZCCHC8	physical	26186194
LBR_HUMAN	LBR	physical	26186194
RNPS1_HUMAN	RNPS1	physical	26186194
DDX50_HUMAN	DDX50	physical	26186194
RT05_HUMAN	MRPS5	physical	26186194
JMJD6_HUMAN	JMJD6	physical	26186194
RBBP6_HUMAN	RBBP6	physical	26186194
CSK22_HUMAN	CSNK2A2	physical	26186194
RBM25_HUMAN	RBM25	physical	26186194
RT09_HUMAN	MRPS9	physical	26186194
SRRT_HUMAN	SRRT	physical	26186194
LARP1_HUMAN	LARP1	physical	26186194
CLK3_HUMAN	CLK3	physical	26186194
PR40A_HUMAN	PRPF40A	physical	26186194
CSK21_HUMAN	CSNK2A1	physical	26186194
PSME3_HUMAN	PSME3	physical	26186194
LC7L3_HUMAN	LUC7L3	physical	26186194
TNPO3_HUMAN	TNPO3	physical	26186194
MRM3_HUMAN	RNMTL1	physical	26186194
RBM7_HUMAN	RBM7	physical	26186194
SRS11_HUMAN	SRSF11	physical	26186194
RT22_HUMAN	MRPS22	physical	26186194
MEPCE_HUMAN	MEPCE	physical	26186194
CASC3_HUMAN	CASC3	physical	26186194
ACINU_HUMAN	ACIN1	physical	26186194
SFR15_HUMAN	SCAF4	physical	26186194
PHF10_HUMAN	PHF10	physical	26186194
RNH1_HUMAN	RNASEH1	physical	26186194
NKTR_HUMAN	NKTR	physical	26186194
CLASR_HUMAN	CLASRP	physical	26186194
SETD2_HUMAN	SETD2	physical	26186194
FRIL_HUMAN	FTL	physical	26186194
PR38B_HUMAN	PRPF38B	physical	26186194
MRS2_HUMAN	MRS2	physical	26186194
CPSF7_HUMAN	CPSF7	physical	26186194
KBTB6_HUMAN	KBTBD6	physical	26186194
VANG2_HUMAN	VANGL2	physical	26186194
CLK2_HUMAN	CLK2	physical	26186194
MKRN1_HUMAN	MKRN1	physical	26186194
YYAP1_HUMAN	YY1AP1	physical	26186194
IKBL1_HUMAN	NFKBIL1	physical	26186194
SRS10_HUMAN	SRSF10	physical	26186194
SRSF8_HUMAN	SRSF8	physical	26186194
PRC2A_HUMAN	PRRC2A	physical	26186194
CAF17_HUMAN	IBA57	physical	26186194
HNRPR_HUMAN	HNRNPR	physical	26344197
RU17_HUMAN	SNRNP70	physical	26344197
SMD1_HUMAN	SNRPD1	physical	26344197
SMD2_HUMAN	SNRPD2	physical	26344197
SMD3_HUMAN	SNRPD3	physical	26344197
HNRPQ_HUMAN	SYNCRIP	physical	26344197
JMJD6_HUMAN	JMJD6	physical	28514442
GPTC8_HUMAN	GPATCH8	physical	28514442
PR38B_HUMAN	PRPF38B	physical	28514442
IKBL1_HUMAN	NFKBIL1	physical	28514442
PININ_HUMAN	PNN	physical	28514442
CLK3_HUMAN	CLK3	physical	28514442
NKTR_HUMAN	NKTR	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
SRSF8_HUMAN	SRSF8	physical	28514442
LC7L2_HUMAN	LUC7L2	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
PHF10_HUMAN	PHF10	physical	28514442
RNPS1_HUMAN	RNPS1	physical	28514442
RBM27_HUMAN	RBM27	physical	28514442
RBM23_HUMAN	RBM23	physical	28514442
CLK2_HUMAN	CLK2	physical	28514442
ZCH18_HUMAN	ZC3H18	physical	28514442
SRPK2_HUMAN	SRPK2	physical	28514442
ACINU_HUMAN	ACIN1	physical	28514442
SRPK1_HUMAN	SRPK1	physical	28514442
FRIL_HUMAN	FTL	physical	28514442
MRM3_HUMAN	RNMTL1	physical	28514442
RNH1_HUMAN	RNASEH1	physical	28514442
MKRN1_HUMAN	MKRN1	physical	28514442
NRDC_HUMAN	NRD1	physical	28514442
DDX50_HUMAN	DDX50	physical	28514442
ZFP91_HUMAN	ZFP91	physical	28514442
MRS2_HUMAN	MRS2	physical	28514442
PPIG_HUMAN	PPIG	physical	28514442
SFR15_HUMAN	SCAF4	physical	28514442
PSME3_HUMAN	PSME3	physical	28514442
SRRM2_HUMAN	SRRM2	physical	28514442
SRRT_HUMAN	SRRT	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
LBR_HUMAN	LBR	physical	28514442
CSK22_HUMAN	CSNK2A2	physical	28514442
MEPCE_HUMAN	MEPCE	physical	28514442
LS14B_HUMAN	LSM14B	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
RM52_HUMAN	MRPL52	physical	28514442
PR40A_HUMAN	PRPF40A	physical	28514442
RBM7_HUMAN	RBM7	physical	28514442
BCLF1_HUMAN	BCLAF1	physical	28514442
SRSF1_HUMAN	SRSF1	physical	28514442
NCBP1_HUMAN	NCBP1	physical	28514442
SRS10_HUMAN	SRSF10	physical	28514442
PRC2A_HUMAN	PRRC2A	physical	28514442
NEUA_HUMAN	CMAS	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
CASC3_HUMAN	CASC3	physical	28514442
CAF17_HUMAN	IBA57	physical	28514442
RM35_HUMAN	MRPL35	physical	28514442
CLASR_HUMAN	CLASRP	physical	28514442
ZC3HE_HUMAN	ZC3H14	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LUC7L_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND MASSSPECTROMETRY.	17081983 [Abstract]