RNH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNH1_HUMAN
• UniProt AC: O60930
• Protein Name: Ribonuclease H1
• Gene Name: RNASEH1
• Organism: Homo sapiens (Human).
• Sequence Length: 286
• Subcellular Localization: Cytoplasm .
• Protein Description: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. [PubMed: 10497183 Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II]
• Protein Sequence: MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	ALPCRRGSRGFGMFY HCCCCCCCCCCCCEE	27.67	-
52	Methylation	ECRAQVDRFPAARFK HHHHHHCCCCHHHHH	40.36	115491333
59	Ubiquitination	RFPAARFKKFATEDE CCCHHHHHHCCCHHH	41.23	-
60	Ubiquitination	FPAARFKKFATEDEA CCHHHHHHCCCHHHH	37.20	-
73	Ubiquitination	EAWAFVRKSASPEVS HHHHHHHHCCCCCCC	45.10	-
74	Phosphorylation	AWAFVRKSASPEVSE HHHHHHHCCCCCCCC	24.34	29255136
76	Phosphorylation	AFVRKSASPEVSEGH HHHHHCCCCCCCCCC	28.78	29255136
80	Phosphorylation	KSASPEVSEGHENQH HCCCCCCCCCCCCCC	35.88	29255136
91	Phosphorylation	ENQHGQESEAKASKR CCCCCCCCHHHHHHH	34.66	23403867
119	Ubiquitination	EPYAKHMKPSVEPAP CHHHHHCCCCCCCCC	33.58	-
175	Methylation	HPLNVGIRLPGRQTN CCCCEEEECCCCCCC	28.97	54558823
192	Ubiquitination	AEIHAACKAIEQAKT HHHHHHHHHHHHHHH	47.90	-
198	Ubiquitination	CKAIEQAKTQNINKL HHHHHHHHHCCCCEE	50.79	-
232	Phosphorylation	WKKNGWKTSAGKEVI HHHCCCCCCCCCEEC	19.80	20860994
233	Phosphorylation	KKNGWKTSAGKEVIN HHCCCCCCCCCEECC	31.15	20860994
236	Ubiquitination	GWKTSAGKEVINKED CCCCCCCCEECCHHH	48.82	-
241	Ubiquitination	AGKEVINKEDFVALE CCCEECCHHHHHHHH	47.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM9S1_HUMAN	TM9SF1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.