dbPTM

CLASR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLASR_HUMAN
UniProt AC	Q8N2M8
Protein Name	CLK4-associating serine/arginine rich protein
Gene Name	CLASRP
Organism	Homo sapiens (Human).
Sequence Length	674
Subcellular Localization	Nucleus.
Protein Description	Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity)..
Protein Sequence	MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Methylation	RKHERKLRGMMVDYK HHHHHHHHHHHCCHH	33.71	115916697
92	Phosphorylation	HLDHIPDYTPPLLTT HHHCCCCCCCCCCCC	18.78	24732914
93	Phosphorylation	LDHIPDYTPPLLTTI HHCCCCCCCCCCCCC	26.30	28464451
98	Phosphorylation	DYTPPLLTTISPEQE CCCCCCCCCCCCCCC	29.75	30266825
99	Phosphorylation	YTPPLLTTISPEQES CCCCCCCCCCCCCCC	21.30	30266825
101	Phosphorylation	PPLLTTISPEQESDE CCCCCCCCCCCCCCH	21.94	23401153
106	Phosphorylation	TISPEQESDERKCNY CCCCCCCCCHHHCCH	44.45	30266825
162	Phosphorylation	KLAEKKASIGYTYED HHHHHHHHCCCEECH	25.98	27251275
180	Phosphorylation	AKVEKAAEKPEEEES HHHHHHHCCCHHHHH	74.20	15302935
195	Phosphorylation	AAEEESNSDEDEVIP HHHHHHCCCCCCCCC	52.21	15302935
228	Phosphorylation	LNKQATTYGMADGDF HHHHHHHHHCCCHHH	10.68	-
259	Sumoylation	AKALEEEKAMYSGRR HHHHHHHHHHHHCHH	41.56	-
259	Sumoylation	AKALEEEKAMYSGRR HHHHHHHHHHHHCHH	41.56	-
262	Phosphorylation	LEEEKAMYSGRRSRR HHHHHHHHHCHHHHH	16.91	28102081
263	Phosphorylation	EEEKAMYSGRRSRRQ HHHHHHHHCHHHHHH	16.85	28102081
267	Phosphorylation	AMYSGRRSRRQRREF HHHHCHHHHHHHHHH	30.38	-
270	Phosphorylation	SGRRSRRQRREFREK HCHHHHHHHHHHHHH	47.90	17081983
279	Phosphorylation	REFREKRLRGRKISP HHHHHHHHCCCCCCC	11.45	17081983
285	O-linked_Glycosylation	RLRGRKISPPSYARR HHCCCCCCCCHHCCC	33.52	30379171
285	Phosphorylation	RLRGRKISPPSYARR HHCCCCCCCCHHCCC	33.52	25159151
288	Phosphorylation	GRKISPPSYARRDSP CCCCCCCHHCCCCCC	34.50	23927012
289	Phosphorylation	RKISPPSYARRDSPT CCCCCCHHCCCCCCC	15.20	23927012
294	Phosphorylation	PSYARRDSPTYDPYK CHHCCCCCCCCCCCC	19.82	25159151
296	Phosphorylation	YARRDSPTYDPYKRS HCCCCCCCCCCCCCC	44.50	23927012
297	Phosphorylation	ARRDSPTYDPYKRSP CCCCCCCCCCCCCCC	20.50	23927012
300	Phosphorylation	DSPTYDPYKRSPSES CCCCCCCCCCCCCCC	19.01	23403867
302	Phosphorylation	PTYDPYKRSPSESSS CCCCCCCCCCCCCCC	48.21	15302935
304	Phosphorylation	YDPYKRSPSESSSES CCCCCCCCCCCCCCH	46.26	15302935
305	Phosphorylation	DPYKRSPSESSSESR CCCCCCCCCCCCCHH	51.89	18452278
308	Phosphorylation	KRSPSESSSESRSRS CCCCCCCCCCHHHCC	33.79	18452278
309	Phosphorylation	RSPSESSSESRSRSR CCCCCCCCCHHHCCC	49.20	18452278
313	Phosphorylation	ESSSESRSRSRSPTP CCCCCHHHCCCCCCC	43.84	15302935
315	Phosphorylation	SSESRSRSRSPTPGR CCCHHHCCCCCCCCC	38.05	24275748
317	Phosphorylation	ESRSRSRSPTPGREE CHHHCCCCCCCCCHH	34.08	24275748
319	Phosphorylation	RSRSRSPTPGREEKI HHCCCCCCCCCHHCE	39.35	25849741
320	Phosphorylation	SRSRSPTPGREEKIT HCCCCCCCCCHHCEE	43.14	15302935
327	Phosphorylation	PGREEKITFITSFGG CCCHHCEEEEECCCC	21.76	28176443
330	Phosphorylation	EEKITFITSFGGSDE HHCEEEEECCCCCHH	17.51	29255136
331	Phosphorylation	EKITFITSFGGSDEE HCEEEEECCCCCHHH	19.65	29255136
335	Phosphorylation	FITSFGGSDEEAAAA EEECCCCCHHHHHHH	42.08	29255136
349	Phosphorylation	AAAAAAASGVTTGKP HHHHHHHHCCCCCCC	29.12	20873877
352	Phosphorylation	AAAASGVTTGKPPAP HHHHHCCCCCCCCCC	33.10	20873877
353	Phosphorylation	AAASGVTTGKPPAPP HHHHCCCCCCCCCCC	40.58	20873877
379	Phosphorylation	SARRRSSSSSSSSSA CCCCCCCCCCCCCCC	35.17	-
380	Phosphorylation	ARRRSSSSSSSSSAS CCCCCCCCCCCCCCC	35.87	-
381	Phosphorylation	RRRSSSSSSSSSASR CCCCCCCCCCCCCCC	35.87	-
382	Phosphorylation	RRSSSSSSSSSASRT CCCCCCCCCCCCCCC	35.87	-
389	Phosphorylation	SSSSASRTSSSRSSS CCCCCCCCCCCCCCC	30.39	-
390	Phosphorylation	SSSASRTSSSRSSSR CCCCCCCCCCCCCCC	25.80	-
391	Phosphorylation	SSASRTSSSRSSSRS CCCCCCCCCCCCCCC	29.20	-
394	Phosphorylation	SRTSSSRSSSRSSSR CCCCCCCCCCCCCCC	34.31	28258704
395	Phosphorylation	RTSSSRSSSRSSSRS CCCCCCCCCCCCCCC	28.76	-
398	Phosphorylation	SSRSSSRSSSRSRRG CCCCCCCCCCCCCCC	34.31	28258704
399	Phosphorylation	SRSSSRSSSRSRRGG CCCCCCCCCCCCCCC	28.76	24260401
417	Phosphorylation	RSGRHARSRSRSWSR CCCHHHCCCCCCCCH	35.08	-
419	Phosphorylation	GRHARSRSRSWSRSR CHHHCCCCCCCCHHH	31.73	20363803
421	Phosphorylation	HARSRSRSWSRSRSR HHCCCCCCCCHHHHH	30.56	20363803
423	Phosphorylation	RSRSRSWSRSRSRSR CCCCCCCCHHHHHHH	22.94	20068231
427	Phosphorylation	RSWSRSRSRSRRYSR CCCCHHHHHHHHHHC	35.54	26657352
429	Phosphorylation	WSRSRSRSRRYSRSR CCHHHHHHHHHHCCC	23.50	26074081
432	Phosphorylation	SRSRSRRYSRSRSRG HHHHHHHHHCCCCCC	13.81	26657352
433	Phosphorylation	RSRSRRYSRSRSRGR HHHHHHHHCCCCCCC	23.20	26074081
435	Phosphorylation	RSRRYSRSRSRGRRH HHHHHHCCCCCCCCC	28.77	26657352
437	Phosphorylation	RRYSRSRSRGRRHSG HHHHCCCCCCCCCCC	40.09	26074081
453	Phosphorylation	GSRDGHRYSRSPARR CCCCCCCCCCCCHHC	11.63	30266825
454	Phosphorylation	SRDGHRYSRSPARRG CCCCCCCCCCCHHCC	26.66	25849741
456	Phosphorylation	DGHRYSRSPARRGGY CCCCCCCCCHHCCCC	19.57	25849741
460	Methylation	YSRSPARRGGYGPRR CCCCCHHCCCCCCCC	45.02	16288549
471	Phosphorylation	GPRRRSRSRSHSGDR CCCCCCCCCCCCCCC	39.11	-
490	Phosphorylation	GRGLRHHSSSRSRSS CCCCCCCCCCCCCCC	24.71	24260401
491	Phosphorylation	RGLRHHSSSRSRSSW CCCCCCCCCCCCCCC	25.97	24260401
494	Phosphorylation	RHHSSSRSRSSWSLS CCCCCCCCCCCCCCC	38.16	20873877
496	Phosphorylation	HSSSRSRSSWSLSPS CCCCCCCCCCCCCCH	37.09	23663014
497	Phosphorylation	SSSRSRSSWSLSPSR CCCCCCCCCCCCCHH	21.41	23663014
499	Phosphorylation	SRSRSSWSLSPSRSR CCCCCCCCCCCHHHC	22.40	23927012
501	O-linked_Glycosylation	SRSSWSLSPSRSRSL CCCCCCCCCHHHCCC	18.47	30379171
501	Phosphorylation	SRSSWSLSPSRSRSL CCCCCCCCCHHHCCC	18.47	23927012
502	Phosphorylation	RSSWSLSPSRSRSLT CCCCCCCCHHHCCCC	38.77	15302935
503	Phosphorylation	SSWSLSPSRSRSLTR CCCCCCCHHHCCCCC	39.24	20363803
505	Phosphorylation	WSLSPSRSRSLTRSR CCCCCHHHCCCCCCC	30.47	20363803
510	Phosphorylation	SRSRSLTRSRSHSPS HHHCCCCCCCCCCCC	35.05	15302935
511	Phosphorylation	RSRSLTRSRSHSPSP HHCCCCCCCCCCCCH	32.66	-
512	Phosphorylation	SRSLTRSRSHSPSPS HCCCCCCCCCCCCHH	34.79	15302935
514	Phosphorylation	SLTRSRSHSPSPSQS CCCCCCCCCCCHHHC	42.49	15302935
515	Phosphorylation	LTRSRSHSPSPSQSR CCCCCCCCCCHHHCC	28.46	22210691
516	Phosphorylation	TRSRSHSPSPSQSRS CCCCCCCCCHHHCCC	44.85	15302935
517	Phosphorylation	RSRSHSPSPSQSRSR CCCCCCCCHHHCCCC	39.95	15302935
518	Phosphorylation	SRSHSPSPSQSRSRS CCCCCCCHHHCCCCC	39.51	15302935
519	Phosphorylation	RSHSPSPSQSRSRSR CCCCCCHHHCCCCCC	45.16	25849741
520	Phosphorylation	SHSPSPSQSRSRSRS CCCCCHHHCCCCCCC	46.37	15302935
521	Phosphorylation	HSPSPSQSRSRSRSR CCCCHHHCCCCCCCC	36.24	22468782
525	Phosphorylation	PSQSRSRSRSRSQSP HHHCCCCCCCCCCCC	35.54	15302935
527	Phosphorylation	QSRSRSRSRSQSPSP HCCCCCCCCCCCCCC	37.21	23663014
529	Phosphorylation	RSRSRSRSQSPSPSP CCCCCCCCCCCCCCH	35.94	23663014
531	Phosphorylation	RSRSRSQSPSPSPAR CCCCCCCCCCCCHHH	28.70	27794612
532	Phosphorylation	SRSRSQSPSPSPARE CCCCCCCCCCCHHHH	42.49	17081983
533	Phosphorylation	RSRSQSPSPSPAREK CCCCCCCCCCHHHHH	43.17	30631047
535	Phosphorylation	RSQSPSPSPAREKLT CCCCCCCCHHHHHCC	35.21	30631047
542	Phosphorylation	SPAREKLTRPAASPA CHHHHHCCCCCCCHH	45.75	23927012
547	Phosphorylation	KLTRPAASPAVGEKL HCCCCCCCHHHHHHH	18.59	29255136
553	Acetylation	ASPAVGEKLKKTEPA CCHHHHHHHHCCCCC	60.73	25953088
556	Sumoylation	AVGEKLKKTEPAAGK HHHHHHHCCCCCCCC	69.43	-
556	Acetylation	AVGEKLKKTEPAAGK HHHHHHHCCCCCCCC	69.43	7306277
556	Sumoylation	AVGEKLKKTEPAAGK HHHHHHHCCCCCCCC	69.43	-
557	O-linked_Glycosylation	VGEKLKKTEPAAGKE HHHHHHCCCCCCCCC	45.68	30379171
563	Acetylation	KTEPAAGKETGAAKP CCCCCCCCCCCCCCC	47.58	7306287
565	Phosphorylation	EPAAGKETGAAKPKL CCCCCCCCCCCCCCC	35.29	26074081
571	Sumoylation	ETGAAKPKLTPQEKL CCCCCCCCCCHHHHH	65.37	-
571	Sumoylation	ETGAAKPKLTPQEKL CCCCCCCCCCHHHHH	65.37	-
573	Phosphorylation	GAAKPKLTPQEKLKL CCCCCCCCHHHHHHH	29.11	25159151
577	Acetylation	PKLTPQEKLKLRMQK CCCCHHHHHHHHHHH	45.75	25953088
600	2-Hydroxyisobutyrylation	DKKAAQEKMIQQEHE HHHHHHHHHHHHHHH	29.26	-
641	Phosphorylation	REEWERQYSRQSRSP HHHHHHHHHHHCCCC	16.43	23090842
642	Phosphorylation	EEWERQYSRQSRSPS HHHHHHHHHHCCCCC	18.59	23090842
645	Phosphorylation	ERQYSRQSRSPSPRY HHHHHHHCCCCCCCC	33.35	20164059
647	Phosphorylation	QYSRQSRSPSPRYSR HHHHHCCCCCCCCCC	34.67	20164059
649	Phosphorylation	SRQSRSPSPRYSREY HHHCCCCCCCCCCHH	24.21	20164059
652	Phosphorylation	SRSPSPRYSREYSSS CCCCCCCCCCHHCHH	18.57	26074081
653	O-linked_Glycosylation	RSPSPRYSREYSSSR CCCCCCCCCHHCHHH	21.66	30379171
653	Phosphorylation	RSPSPRYSREYSSSR CCCCCCCCCHHCHHH	21.66	26074081
656	Phosphorylation	SPRYSREYSSSRRRS CCCCCCHHCHHHHHH	16.85	26074081
657	Phosphorylation	PRYSREYSSSRRRSR CCCCCHHCHHHHHHC	19.65	26074081
658	Phosphorylation	RYSREYSSSRRRSRS CCCCHHCHHHHHHCC	27.28	24719451
659	Phosphorylation	YSREYSSSRRRSRSR CCCHHCHHHHHHCCC	24.70	26074081
665	Phosphorylation	SSRRRSRSRSRSPHY HHHHHHCCCCCCCCC	35.54	29449344
667	Phosphorylation	RRRSRSRSRSPHYRH HHHHCCCCCCCCCCC	38.05	30177828
669	Phosphorylation	RSRSRSRSPHYRH-- HHCCCCCCCCCCC--	19.78	30177828
672	Phosphorylation	SRSRSPHYRH----- CCCCCCCCCC-----	17.48	30177828

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLASR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLASR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLASR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHXF2_HUMAN	RHOXF2	physical	16189514
CLK4_HUMAN	CLK4	physical	12169693
A4_HUMAN	APP	physical	21832049
ATX1L_HUMAN	ATXN1L	physical	28514442
LC7L2_HUMAN	LUC7L2	physical	28514442
ATX1_HUMAN	ATXN1	physical	28514442
PUM2_HUMAN	PUM2	physical	28514442
GAK_HUMAN	GAK	physical	28514442
ACADV_HUMAN	ACADVL	physical	28514442
ZN703_HUMAN	ZNF703	physical	28514442
RBM38_HUMAN	RBM38	physical	28514442
PUM1_HUMAN	PUM1	physical	28514442
ATX2_HUMAN	ATXN2	physical	28514442
EED_HUMAN	EED	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLASR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331 AND SER-335, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-331 ANDSER-335, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-294 ANDSER-547, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; THR-319; SER-335;SER-531; SER-533 AND SER-535, AND MASS SPECTROMETRY.	15302935 [Abstract]