ATX1L_HUMAN - dbPTM
ATX1L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATX1L_HUMAN
UniProt AC P0C7T5
Protein Name Ataxin-1-like
Gene Name ATXN1L
Organism Homo sapiens (Human).
Sequence Length 689
Subcellular Localization Nucleus . Cell projection, dendrite . Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
Protein Description Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. [PubMed: 21475249 Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1 In concert with CIC and ATXN1, involved in brain development (By similarity]
Protein Sequence MKPVHERSQECLPPKKRDLPVTSEDMGRTTSCSTNHTPSSDASEWSRGVVVAGQSQAGARVSLGGDGAEAITGLTVDQYGMLYKVAVPPATFSPTGLPSVVNMSPLPPTFNVASSLIQHPGIHYPPLHYAQLPSTSLQFIGSPYSLPYAVPPNFLPSPLLSPSANLATSHLPHFVPYASLLAEGATPPPQAPSPAHSFNKAPSATSPSGQLPHHSSTQPLDLAPGRMPIYYQMSRLPAGYTLHETPPAGASPVLTPQESQSALEAAAANGGQRPRERNLVRRESEALDSPNSKGEGQGLVPVVECVVDGQLFSGSQTPRVEVAAPAHRGTPDTDLEVQRVVGALASQDYRVVAAQRKEEPSPLNLSHHTPDHQGEGRGSARNPAELAEKSQARGFYPQSHQEPVKHRPLPKAMVVANGNLVPTGTDSGLLPVGSEILVASSLDVQARATFPDKEPTPPPITSSHLPSHFMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTVVDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTTQLFSLPCHRLQVGDVCISISLQSLNSNSVSQASCAPPSQLGPPRERPERTVLGSRELCDSEGKSQPAGEGSRVVEPSQPESGAQACWPAPSFQRYSMQGEEARAALLRPSFIPQEVKLSIEGRSNAGK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MKPVHERSQ
------CCCCCHHHH		56.6023749302
22PhosphorylationKKRDLPVTSEDMGRT
CCCCCCCCCHHHCCC		25.1828450419
22O-linked_GlycosylationKKRDLPVTSEDMGRT
CCCCCCCCCHHHCCC		25.1830059200
23O-linked_GlycosylationKRDLPVTSEDMGRTT
CCCCCCCCHHHCCCC		31.6530059200
23PhosphorylationKRDLPVTSEDMGRTT
CCCCCCCCHHHCCCC		31.6528450419
29O-linked_GlycosylationTSEDMGRTTSCSTNH
CCHHHCCCCCCCCCC		19.8230059200
29PhosphorylationTSEDMGRTTSCSTNH
CCHHHCCCCCCCCCC		19.8227251275
30PhosphorylationSEDMGRTTSCSTNHT
CHHHCCCCCCCCCCC		26.7827251275
31PhosphorylationEDMGRTTSCSTNHTP
HHHCCCCCCCCCCCC		12.8827251275
33PhosphorylationMGRTTSCSTNHTPSS
HCCCCCCCCCCCCCC		31.8227251275
34PhosphorylationGRTTSCSTNHTPSSD
CCCCCCCCCCCCCCC		35.0327251275
40O-linked_GlycosylationSTNHTPSSDASEWSR
CCCCCCCCCHHHHCC		38.1030059200
62O-linked_GlycosylationSQAGARVSLGGDGAE
CCCCCEEECCCCCHH		18.7530059200
62PhosphorylationSQAGARVSLGGDGAE
CCCCCEEECCCCCHH		18.7525106551
72PhosphorylationGDGAEAITGLTVDQY
CCCHHHHCCCEEHHC		32.9422210691
203PhosphorylationHSFNKAPSATSPSGQ
CCCCCCCCCCCCCCC		49.3823927012
205PhosphorylationFNKAPSATSPSGQLP
CCCCCCCCCCCCCCC		45.5725159151
206PhosphorylationNKAPSATSPSGQLPH
CCCCCCCCCCCCCCC		19.4525159151
208PhosphorylationAPSATSPSGQLPHHS
CCCCCCCCCCCCCCC		38.6523927012
215PhosphorylationSGQLPHHSSTQPLDL
CCCCCCCCCCCCCCC		31.8530108239
215O-linked_GlycosylationSGQLPHHSSTQPLDL
CCCCCCCCCCCCCCC		31.8530059200
216O-linked_GlycosylationGQLPHHSSTQPLDLA
CCCCCCCCCCCCCCC		27.0630059200
216PhosphorylationGQLPHHSSTQPLDLA
CCCCCCCCCCCCCCC		27.0630108239
217PhosphorylationQLPHHSSTQPLDLAP
CCCCCCCCCCCCCCC		36.9028464451
217O-linked_GlycosylationQLPHHSSTQPLDLAP
CCCCCCCCCCCCCCC		36.9030059200
230PhosphorylationAPGRMPIYYQMSRLP
CCCCCCEEEECCCCC		5.0419901323
231PhosphorylationPGRMPIYYQMSRLPA
CCCCCEEEECCCCCC		9.8427642862
240PhosphorylationMSRLPAGYTLHETPP
CCCCCCCCEEECCCC		14.2925850435
241PhosphorylationSRLPAGYTLHETPPA
CCCCCCCEEECCCCC		22.2625850435
245PhosphorylationAGYTLHETPPAGASP
CCCEEECCCCCCCCC		24.6725850435
251PhosphorylationETPPAGASPVLTPQE
CCCCCCCCCCCCHHH		18.0225850435
255PhosphorylationAGASPVLTPQESQSA
CCCCCCCCHHHHHHH		24.1425921289
259PhosphorylationPVLTPQESQSALEAA
CCCCHHHHHHHHHHH		24.9625850435
261PhosphorylationLTPQESQSALEAAAA
CCHHHHHHHHHHHHH		44.0625002506
284PhosphorylationRNLVRRESEALDSPN
HHHHHHHHHHHCCCC		26.7623401153
289PhosphorylationRESEALDSPNSKGEG
HHHHHHCCCCCCCCC		27.1629255136
292PhosphorylationEALDSPNSKGEGQGL
HHHCCCCCCCCCCCE		45.4823927012
313PhosphorylationVVDGQLFSGSQTPRV
EEECEECCCCCCCCE		46.2428348404
315PhosphorylationDGQLFSGSQTPRVEV
ECEECCCCCCCCEEE		29.6828348404
317PhosphorylationQLFSGSQTPRVEVAA
EECCCCCCCCEEEEC		18.1127251275
330PhosphorylationAAPAHRGTPDTDLEV
ECCCCCCCCCCHHHH		20.2519664994
333PhosphorylationAHRGTPDTDLEVQRV
CCCCCCCCHHHHHHH		43.6230266825
346PhosphorylationRVVGALASQDYRVVA
HHHHHHHCCCHHEEE		25.1628555341
349PhosphorylationGALASQDYRVVAAQR
HHHHCCCHHEEEEEC		9.5426074081
361PhosphorylationAQRKEEPSPLNLSHH
EECCCCCCCCCCCCC		45.3530266825
366PhosphorylationEPSPLNLSHHTPDHQ
CCCCCCCCCCCCCCC		16.4930266825
369PhosphorylationPLNLSHHTPDHQGEG
CCCCCCCCCCCCCCC		25.6229255136
389AcetylationNPAELAEKSQARGFY
CHHHHHHHHHHCCCC		42.1125953088
405UbiquitinationQSHQEPVKHRPLPKA
CCCCCCCCCCCCCCE		44.6129967540
449PhosphorylationLDVQARATFPDKEPT
CCEEEECCCCCCCCC		30.1029255136
456PhosphorylationTFPDKEPTPPPITSS
CCCCCCCCCCCCCCC		49.9029255136
461PhosphorylationEPTPPPITSSHLPSH
CCCCCCCCCCCCCHH		29.9223403867
462PhosphorylationPTPPPITSSHLPSHF
CCCCCCCCCCCCHHH		19.2423403867
463PhosphorylationTPPPITSSHLPSHFM
CCCCCCCCCCCHHHH		22.0123403867
467PhosphorylationITSSHLPSHFMKGAI
CCCCCCCHHHHHHHH		35.4023403867
500PhosphorylationFVRSAEVSGGLKIDS
HHHHEEECCCEEECC		20.7424702127
611PhosphorylationPRERPERTVLGSREL
CCCCCCCEEECCHHC		20.5830108239
615PhosphorylationPERTVLGSRELCDSE
CCCEEECCHHCCCCC		20.5823927012
621PhosphorylationGSRELCDSEGKSQPA
CCHHCCCCCCCCCCC		47.4528450419
625PhosphorylationLCDSEGKSQPAGEGS
CCCCCCCCCCCCCCC		52.8623312004
632PhosphorylationSQPAGEGSRVVEPSQ
CCCCCCCCCCCCCCC		20.0123312004
664MethylationSMQGEEARAALLRPS
CCCHHHHHHHHHCCH		24.55-
671PhosphorylationRAALLRPSFIPQEVK
HHHHHCCHHCCCEEE		29.40-
680PhosphorylationIPQEVKLSIEGRSNA
CCCEEEEEEECCCCC		16.9324719451
685PhosphorylationKLSIEGRSNAGK---
EEEEECCCCCCC---		41.7225159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATX1L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATX1L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATX1L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCOR2_HUMANNCOR2physical
16121196
ATX1L_HUMANATXN1Lphysical
16121196
ATX1_HUMANATXN1physical
16121196
CTBP2_HUMANCTBP2physical
16713569
DAZP2_HUMANDAZAP2physical
16713569
GORS2_HUMANGORASP2physical
16713569
NBR1_HUMANNBR1physical
16713569
MEOX2_HUMANMEOX2physical
16713569
RBPMS_HUMANRBPMSphysical
16713569
AES_HUMANAESphysical
16713569
ANKH1_HUMANANKHD1physical
16713569
APBB1_HUMANAPBB1physical
16713569
ATX1_HUMANATXN1physical
16713569
PRC2A_HUMANPRRC2Aphysical
16713569
COIL_HUMANCOILphysical
16713569
CTBP1_HUMANCTBP1physical
16713569
ELP5_HUMANELP5physical
16713569
H2AY_HUMANH2AFYphysical
16713569
HGS_HUMANHGSphysical
16713569
ZEP1_HUMANHIVEP1physical
16713569
PRC2B_HUMANPRRC2Bphysical
16713569
GPTC8_HUMANGPATCH8physical
16713569
ZSWM8_HUMANZSWIM8physical
16713569
HSFX1_HUMANHSFX1physical
16713569
RFOX2_HUMANRBFOX2physical
16713569
RRAGC_HUMANRRAGCphysical
16713569
ARIP4_HUMANRAD54L2physical
16713569
UBP54_HUMANUSP54physical
16713569
ACON_HUMANACO2physical
16713569
E41L2_HUMANEPB41L2physical
16713569
E41L3_HUMANEPB41L3physical
16713569
THY1_HUMANTHY1physical
16713569
AA1R_HUMANADORA1physical
16713569
AP1G2_HUMANAP1G2physical
16713569
AP2M1_HUMANAP2M1physical
16713569
BACH_HUMANACOT7physical
16713569
TMM8B_HUMANTMEM8Bphysical
16713569
MTG8R_HUMANCBFA2T2physical
16713569
CHD6_HUMANCHD6physical
16713569
ALG13_HUMANALG13physical
16713569
DAB2_HUMANDAB2physical
16713569
FADS2_HUMANFADS2physical
16713569
MET17_HUMANMETTL17physical
16713569
FUS_HUMANFUSphysical
16713569
GAS7_HUMANGAS7physical
16713569
GMEB2_HUMANGMEB2physical
16713569
CAMP2_HUMANCAMSAP2physical
16713569
AF1L2_HUMANAFAP1L2physical
16713569
MATN2_HUMANMATN2physical
16713569
MBD1_HUMANMBD1physical
16713569
MBD6_HUMANMBD6physical
16713569
NIT1_HUMANNIT1physical
16713569
PHP14_HUMANPHPT1physical
16713569
PICK1_HUMANPICK1physical
16713569
Z3H7B_HUMANZC3H7Bphysical
16713569
SUGP2_HUMANSUGP2physical
16713569
SCAFB_HUMANSCAF11physical
16713569
SMRC2_HUMANSMARCC2physical
16713569
SRBP1_HUMANSREBF1physical
16713569
SIA7F_HUMANST6GALNAC6physical
16713569
STAC2_HUMANSTAC2physical
16713569
TMM25_HUMANTMEM25physical
16713569
TRIPB_HUMANTRIP11physical
16713569
YYAP1_HUMANYY1AP1physical
16713569
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATX1L_HUMAN

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Related Literatures of Post-Translational Modification

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