STAC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAC2_HUMAN
• UniProt AC: Q6ZMT1
• Protein Name: SH3 and cysteine-rich domain-containing protein 2
• Gene Name: STAC2
• Organism: Homo sapiens (Human).
• Sequence Length: 411
• Subcellular Localization: Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with CACNA1C at the plasma membrane of transfected cells.
• Protein Description: Slows down the inactivation rate of the calcium channel CACNA1C..
• Protein Sequence: MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	NEPDDAATHSPPGTV CCCCCCHHCCCCCHH	25.30	25307156
18	Phosphorylation	PDDAATHSPPGTVSA CCCCHHCCCCCHHHH	28.56	25307156
37	Phosphorylation	KLQRFKRSLSLKTIL HHHHHHHHCCHHHHH	23.93	24719451
39	Phosphorylation	QRFKRSLSLKTILRS HHHHHHCCHHHHHHC	29.12	24719451
46	Phosphorylation	SLKTILRSKSLENFF CHHHHHHCCCHHHHH	24.13	28857561
48	Phosphorylation	KTILRSKSLENFFLR HHHHHCCCHHHHHCC	42.01	22167270
64	Phosphorylation	GSELKCPTEVLLTPP CCCCCCCCEEEECCC	48.47	27251275
69	Phosphorylation	CPTEVLLTPPTPLPP CCCEEEECCCCCCCC	24.06	27251275
72	Phosphorylation	EVLLTPPTPLPPPSP EEEECCCCCCCCCCC	38.37	29449344
78	Phosphorylation	PTPLPPPSPPPTASD CCCCCCCCCCCCCCC	56.67	27251275
82	Phosphorylation	PPPSPPPTASDRGLA CCCCCCCCCCCCCCC	44.56	27251275
84	Phosphorylation	PSPPPTASDRGLATP CCCCCCCCCCCCCCC	30.25	27251275
90	Phosphorylation	ASDRGLATPSPSPCP CCCCCCCCCCCCCCC	29.37	22167270
92	Phosphorylation	DRGLATPSPSPCPVP CCCCCCCCCCCCCCC	33.39	22167270
94	Phosphorylation	GLATPSPSPCPVPRP CCCCCCCCCCCCCCC	43.39	22167270
112	Phosphorylation	LKPVRLHSFQEHVFK CCCEECCCHHHHHHH	32.96	28348404
122	Phosphorylation	EHVFKRASPCELCHQ HHHHHHCCHHHHCCH	33.83	-
135	Phosphorylation	HQLIVGNSKQGLRCK CHHHCCCCCCCCCCC	22.04	-
174	Phosphorylation	TSFRRNFSSPLLVHE HHHCCCCCCCEEECC	34.30	27251275
175	Phosphorylation	SFRRNFSSPLLVHEP HHCCCCCCCEEECCC	18.54	27251275
188	Phosphorylation	EPPPVCATSKESPPT CCCCEECCCCCCCCC	34.89	28348404
189	Phosphorylation	PPPVCATSKESPPTG CCCEECCCCCCCCCC	18.85	28348404
192	Phosphorylation	VCATSKESPPTGDSG EECCCCCCCCCCCCC	39.66	26356563
195	Phosphorylation	TSKESPPTGDSGKVD CCCCCCCCCCCCCCC	57.94	29449344
198	Phosphorylation	ESPPTGDSGKVDPVY CCCCCCCCCCCCHHH	41.69	29449344
205	Phosphorylation	SGKVDPVYETLRYGT CCCCCHHHHHHHHHC	14.48	26356563
207	Phosphorylation	KVDPVYETLRYGTSL CCCHHHHHHHHHCCE	9.99	26356563
210	Phosphorylation	PVYETLRYGTSLALM HHHHHHHHHCCEEEE	28.06	30576142
220	Phosphorylation	SLALMNRSSFSSTSE CEEEEECCCCCCCCC	30.63	27251275
221	Phosphorylation	LALMNRSSFSSTSES EEEEECCCCCCCCCC	26.38	27251275
223	Phosphorylation	LMNRSSFSSTSESPT EEECCCCCCCCCCCC	34.35	27251275
224	Phosphorylation	MNRSSFSSTSESPTR EECCCCCCCCCCCCC	33.66	20044836
225	Phosphorylation	NRSSFSSTSESPTRS ECCCCCCCCCCCCCC	35.00	20044836
226	Phosphorylation	RSSFSSTSESPTRSL CCCCCCCCCCCCCCH	37.72	25307156
228	Phosphorylation	SFSSTSESPTRSLSE CCCCCCCCCCCCHHH	31.19	30576142
230	Phosphorylation	SSTSESPTRSLSERD CCCCCCCCCCHHHHH	42.01	30576142
232	Phosphorylation	TSESPTRSLSERDEL CCCCCCCCHHHHHCC	38.43	29449344
234	Phosphorylation	ESPTRSLSERDELTE CCCCCCHHHHHCCCC	31.65	27251275
240	Phosphorylation	LSERDELTEDGEGSI HHHHHCCCCCCCCCC	29.95	27251275
246	Phosphorylation	LTEDGEGSIRSSEEG CCCCCCCCCCCCCCC	15.55	27251275
259	Phosphorylation	EGPGDSASPVFTAPA CCCCCCCCCCEECCC	26.08	28348404
263	Phosphorylation	DSASPVFTAPAESEG CCCCCCEECCCCCCC	31.78	28348404
277	Phosphorylation	GPGPEEKSPGQQLPK CCCCCCCCCCCCCCC	37.23	27251275
295	Phosphorylation	RKDVGPMYSYVALYK CCCCCHHHHHHHHHH	10.45	27251275
301	Phosphorylation	MYSYVALYKFLPQEN HHHHHHHHHHCCCCC	7.03	27251275
372	Phosphorylation	NKEQGYMSLKENQIC CCHHCCEEECCCEEE	28.01	28348404
409	Phosphorylation	LVPVDALTEI----- EEEHHHHCCC-----	33.10	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.