FADS2_HUMAN - dbPTM
FADS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FADS2_HUMAN
UniProt AC O95864
Protein Name Fatty acid desaturase 2
Gene Name FADS2
Organism Homo sapiens (Human).
Sequence Length 444
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum..
Protein Sequence MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYLHK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Ubiquitination-----MGKGGNQGEG
-----CCCCCCCCCC		63.4533845483
28AcetylationFSWEEIQKHNLRTDR
ECHHHHHHCCCCCCE		39.8725953088
28UbiquitinationFSWEEIQKHNLRTDR
ECHHHHHHCCCCCCE		39.8723000965
28 (in isoform 1)Ubiquitination-39.8721890473
28 (in isoform 3)Ubiquitination-39.8721890473
42UbiquitinationRWLVIDRKVYNITKW
EEEEEEEEEEEEEEE		45.3723000965
44PhosphorylationLVIDRKVYNITKWSI
EEEEEEEEEEEEEEE		12.1321253578
48AcetylationRKVYNITKWSIQHPG
EEEEEEEEEEEECCC		34.8425953088
48UbiquitinationRKVYNITKWSIQHPG
EEEEEEEEEEEECCC		34.8423000965
48 (in isoform 1)Ubiquitination-34.8421890473
48 (in isoform 3)Ubiquitination-34.8421890473
53UbiquitinationITKWSIQHPGGQRVI
EEEEEEECCCCCEEE		22.69-
53UbiquitinationITKWSIQHPGGQRVI
EEEEEEECCCCCEEE		22.6921890473
56UbiquitinationWSIQHPGGQRVIGHY
EEEECCCCCEEEEEE		19.30-
56UbiquitinationWSIQHPGGQRVIGHY
EEEECCCCCEEEEEE		19.3023000965
62UbiquitinationGGQRVIGHYAGEDAT
CCCEEEEEECCCCHH		9.7221890473
62UbiquitinationGGQRVIGHYAGEDAT
CCCEEEEEECCCCHH		9.7221890473
62 (in isoform 2)Ubiquitination-9.7221890473
63PhosphorylationGQRVIGHYAGEDATD
CCEEEEEECCCCHHH		15.8727642862
65UbiquitinationRVIGHYAGEDATDAF
EEEEEECCCCHHHHH		26.5921890473
65UbiquitinationRVIGHYAGEDATDAF
EEEEEECCCCHHHHH		26.5923000965
65 (in isoform 2)Ubiquitination-26.5921890473
74UbiquitinationDATDAFRAFHPDLEF
CHHHHHHHHCCCHHH		10.72-
74UbiquitinationDATDAFRAFHPDLEF
CHHHHHHHHCCCHHH		10.7223000965
77UbiquitinationDAFRAFHPDLEFVGK
HHHHHHCCCHHHHHH		41.23-
77UbiquitinationDAFRAFHPDLEFVGK
HHHHHHCCCHHHHHH		41.2323000965
83UbiquitinationHPDLEFVGKFLKPLL
CCCHHHHHHHHHHHH		21.9623000965
83 (in isoform 2)Ubiquitination-21.96-
84UbiquitinationPDLEFVGKFLKPLLI
CCHHHHHHHHHHHHH		42.0723000965
84 (in isoform 1)Ubiquitination-42.0721890473
84 (in isoform 3)Ubiquitination-42.0721890473
86UbiquitinationLEFVGKFLKPLLIGE
HHHHHHHHHHHHHCC		6.7723000965
86 (in isoform 2)Ubiquitination-6.77-
87UbiquitinationEFVGKFLKPLLIGEL
HHHHHHHHHHHHCCC		36.43-
87UbiquitinationEFVGKFLKPLLIGEL
HHHHHHHHHHHHCCC		36.4323000965
87 (in isoform 1)Ubiquitination-36.4321890473
87 (in isoform 3)Ubiquitination-36.4321890473
96UbiquitinationLLIGELAPEEPSQDH
HHHCCCCCCCCCCCC		60.1433845483
96 (in isoform 2)Ubiquitination-60.14-
105UbiquitinationEPSQDHGKNSKITED
CCCCCCCCCCHHHHH		55.4123000965
108UbiquitinationQDHGKNSKITEDFRA
CCCCCCCHHHHHHHH		64.1423000965
118UbiquitinationEDFRALRKTAEDMNL
HHHHHHHHHHHHHCC		53.5933845483
161UbiquitinationFGNGWIPTLITAFVL
CCCCHHHHHHHHHHH		22.97-
161UbiquitinationFGNGWIPTLITAFVL
CCCCHHHHHHHHHHH		22.9729967540
168UbiquitinationTLITAFVLATSQAQA
HHHHHHHHHHCHHHH		3.30-
170UbiquitinationITAFVLATSQAQAGW
HHHHHHHHCHHHHCC		19.7429967540
175UbiquitinationLATSQAQAGWLQHDY
HHHCHHHHCCCCCCC		17.72-
175UbiquitinationLATSQAQAGWLQHDY
HHHCHHHHCCCCCCC		17.7221890473
184UbiquitinationWLQHDYGHLSVYRKP
CCCCCCCCCEEECCC		14.5421890473
184UbiquitinationWLQHDYGHLSVYRKP
CCCCCCCCCEEECCC		14.5421890473
184 (in isoform 2)Ubiquitination-14.5421890473
186PhosphorylationQHDYGHLSVYRKPKW
CCCCCCCEEECCCCH		16.0724719451
192UbiquitinationLSVYRKPKWNHLVHK
CEEECCCCHHHHHHH		64.76-
192UbiquitinationLSVYRKPKWNHLVHK
CEEECCCCHHHHHHH		64.7623000965
198UbiquitinationPKWNHLVHKFVIGHL
CCHHHHHHHHHHHHH		24.9723000965
199UbiquitinationKWNHLVHKFVIGHLK
CHHHHHHHHHHHHHC		33.57-
201UbiquitinationNHLVHKFVIGHLKGA
HHHHHHHHHHHHCCC		6.4623000965
206UbiquitinationKFVIGHLKGASANWW
HHHHHHHCCCCCCCH		46.9121890473
206 (in isoform 1)Ubiquitination-46.9121890473
206 (in isoform 3)Ubiquitination-46.9121890473
207UbiquitinationFVIGHLKGASANWWN
HHHHHHCCCCCCCHH		30.9923000965
220UbiquitinationWNHRHFQHHAKPNIF
HHHHHHHHCCCCCCC		23.17-
220UbiquitinationWNHRHFQHHAKPNIF
HHHHHHHHCCCCCCC		23.1733845483
221UbiquitinationNHRHFQHHAKPNIFH
HHHHHHHCCCCCCCC		25.3523503661
222UbiquitinationHRHFQHHAKPNIFHK
HHHHHHCCCCCCCCC		27.2023503661
223UbiquitinationRHFQHHAKPNIFHKD
HHHHHCCCCCCCCCC		33.9523000965
224UbiquitinationHFQHHAKPNIFHKDP
HHHHCCCCCCCCCCC		39.6823503661
229UbiquitinationAKPNIFHKDPDVNML
CCCCCCCCCCCCCEE		61.2723000965
229 (in isoform 2)Ubiquitination-61.27-
230UbiquitinationKPNIFHKDPDVNMLH
CCCCCCCCCCCCEEE		35.7423503661
231UbiquitinationPNIFHKDPDVNMLHV
CCCCCCCCCCCEEEE		52.8623503661
233UbiquitinationIFHKDPDVNMLHVFV
CCCCCCCCCEEEEEE		5.7323503661
251UbiquitinationWQPIEYGKKKLKYLP
CEEECCCCCCCEECC		45.9233845483
252UbiquitinationQPIEYGKKKLKYLPY
EEECCCCCCCEECCC		60.0023503661
253UbiquitinationPIEYGKKKLKYLPYN
EECCCCCCCEECCCC		54.4123503661
255UbiquitinationEYGKKKLKYLPYNHQ
CCCCCCCEECCCCCC		54.3323503661
367UbiquitinationLTATCNVEQSFFNDW
HHCCCCCCHHHHCCH		26.90-
367UbiquitinationLTATCNVEQSFFNDW
HHCCCCCCHHHHCCH		26.9023000965
373UbiquitinationVEQSFFNDWFSGHLN
CCHHHHCCHHHCCCC		42.51-
373UbiquitinationVEQSFFNDWFSGHLN
CCHHHHCCHHHCCCC		42.5123000965
376UbiquitinationSFFNDWFSGHLNFQI
HHHCCHHHCCCCEEE		22.5021890473
376UbiquitinationSFFNDWFSGHLNFQI
HHHCCHHHCCCCEEE		22.5023000965
376 (in isoform 2)Ubiquitination-22.5021890473
378UbiquitinationFNDWFSGHLNFQIEH
HCCHHHCCCCEEEEE		19.19-
378UbiquitinationFNDWFSGHLNFQIEH
HCCHHHCCCCEEEEE		19.1923000965
382UbiquitinationFSGHLNFQIEHHLFP
HHCCCCEEEEECCCC		38.8021890473
382UbiquitinationFSGHLNFQIEHHLFP
HHCCCCEEEEECCCC		38.8023000965
382 (in isoform 2)Ubiquitination-38.8021890473
386UbiquitinationLNFQIEHHLFPTMPR
CCEEEEECCCCCCCC		19.17-
386UbiquitinationLNFQIEHHLFPTMPR
CCEEEEECCCCCCCC		19.1723000965
387UbiquitinationNFQIEHHLFPTMPRH
CEEEEECCCCCCCCC		6.2423000965
395UbiquitinationFPTMPRHNLHKIAPL
CCCCCCCCHHHHHHH		45.1521890473
395UbiquitinationFPTMPRHNLHKIAPL
CCCCCCCCHHHHHHH		45.1523000965
395 (in isoform 2)Ubiquitination-45.1521890473
398UbiquitinationMPRHNLHKIAPLVKS
CCCCCHHHHHHHHHH		43.6723000965
398 (in isoform 1)Ubiquitination-43.6721890473
400UbiquitinationRHNLHKIAPLVKSLC
CCCHHHHHHHHHHHH		9.0023000965
401UbiquitinationHNLHKIAPLVKSLCA
CCHHHHHHHHHHHHH		40.95-
401UbiquitinationHNLHKIAPLVKSLCA
CCHHHHHHHHHHHHH		40.9523000965
404UbiquitinationHKIAPLVKSLCAKHG
HHHHHHHHHHHHHCC		45.45-
404UbiquitinationHKIAPLVKSLCAKHG
HHHHHHHHHHHHHCC		45.4523000965
404 (in isoform 1)Ubiquitination-45.4521890473
409UbiquitinationLVKSLCAKHGIEYQE
HHHHHHHHCCCCCCC		41.1723000965
410UbiquitinationVKSLCAKHGIEYQEK
HHHHHHHCCCCCCCH		24.7623000965
413UbiquitinationLCAKHGIEYQEKPLL
HHHHCCCCCCCHHHH		45.8421890473
413UbiquitinationLCAKHGIEYQEKPLL
HHHHCCCCCCCHHHH		45.8423000965
413 (in isoform 2)Ubiquitination-45.8421890473
417UbiquitinationHGIEYQEKPLLRALL
CCCCCCCHHHHHHHH		25.9923000965
417 (in isoform 1)Ubiquitination-25.9921890473
422UbiquitinationQEKPLLRALLDIIRS
CCHHHHHHHHHHHHH		16.6723000965
431UbiquitinationLDIIRSLKKSGKLWL
HHHHHHHHHHCCEEH		46.2523000965
432UbiquitinationDIIRSLKKSGKLWLD
HHHHHHHHHCCEEHH		70.5023000965
435UbiquitinationRSLKKSGKLWLDAYL
HHHHHHCCEEHHHHC		43.5123000965
435 (in isoform 1)Ubiquitination-43.5121890473
444UbiquitinationWLDAYLHK-------
EHHHHCCC-------		60.4823000965
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FADS2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FADS2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FADS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FADS2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00132Alpha-Linolenic Acid
Regulatory Network of FADS2_HUMAN

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Related Literatures of Post-Translational Modification

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