ACON_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACON_HUMAN
• UniProt AC: Q99798
• Protein Name: Aconitate hydratase, mitochondrial
• Gene Name: ACO2
• Organism: Homo sapiens (Human).
• Sequence Length: 780
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate..
• Protein Sequence: MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAPYSLLVTRL ----CCCHHHHHHHH	11.47	24043423
5	Phosphorylation	---MAPYSLLVTRLQ ---CCCHHHHHHHHH	17.73	24043423
9	Phosphorylation	APYSLLVTRLQKALG CCHHHHHHHHHHHHC	26.15	68736429
13	Ubiquitination	LLVTRLQKALGVRQY HHHHHHHHHHCCCHH	50.61	27667366
28	Pyrrolidone_carboxylic_acid	HVASVLCQRAKVAMS HHHHHHHHHHHHHHH	44.18	-
31	Succinylation	SVLCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	-
31	Succinylation	SVLCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	-
35	Ubiquitination	QRAKVAMSHFEPNEY HHHHHHHHCCCCCCC	18.45	23503661
42	Phosphorylation	SHFEPNEYIHYDLLE HCCCCCCCCCHHHHH	10.31	46157845
50	Acetylation	IHYDLLEKNINIVRK CCHHHHHHHHHHHHH	64.20	23954790
50	Succinylation	IHYDLLEKNINIVRK CCHHHHHHHHHHHHH	64.20	-
50	Succinylation	IHYDLLEKNINIVRK CCHHHHHHHHHHHHH	64.20	-
64	Phosphorylation	KRLNRPLTLSEKIVY HHCCCCCCHHCHHHC	30.81	23612710
66	Phosphorylation	LNRPLTLSEKIVYGH CCCCCCHHCHHHCCC	31.44	23612710
68	Ubiquitination	RPLTLSEKIVYGHLD CCCCHHCHHHCCCCC	33.81	23503661
79	Phosphorylation	GHLDDPASQEIERGK CCCCCHHHHHHHHCC	33.46	110757307
87	Phosphorylation	QEIERGKSYLRLRPD HHHHHCCCCEECCCC	32.02	46157821
102	Phosphorylation	RVAMQDATAQMAMLQ HHHHHHHHHHHHHHH	26.22	29978859
105	Ubiquitination	MQDATAQMAMLQFIS HHHHHHHHHHHHHHH	1.88	23503661
111	Ubiquitination	QMAMLQFISSGLSKV HHHHHHHHHCCCCCC	1.75	23503661
112	Phosphorylation	MAMLQFISSGLSKVA HHHHHHHHCCCCCCC	21.46	29978859
113	Phosphorylation	AMLQFISSGLSKVAV HHHHHHHCCCCCCCC	38.65	29978859
116	Phosphorylation	QFISSGLSKVAVPST HHHHCCCCCCCCCCE	28.71	28857561
138	Acetylation	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	25953088
138	Succinylation	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	-
138	Succinylation	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	-
138	Ubiquitination	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	23503661
144	2-Hydroxyisobutyrylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	-
144	Acetylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	23749302
144	Succinylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	-
144	Succinylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	-
144	Ubiquitination	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	23503661
151	Nitration	KDINQEVYNFLATAG HHHCHHHHHHHHHCC	10.23	-
151	Phosphorylation	KDINQEVYNFLATAG HHHCHHHHHHHHHCC	10.23	31136877
156	Phosphorylation	EVYNFLATAGAKYGV HHHHHHHHCCCCCCC	27.98	25003641
160	Acetylation	FLATAGAKYGVGFWK HHHHCCCCCCCCEEC	41.44	25038526
193	O-linked_Glycosylation	VLLIGTDSHTPNGGG EEEEECCCCCCCCCC	29.15	28510447
212	Ubiquitination	CIGVGGADAVDVMAG EEECCCCCHHHHHCC	50.85	23503661
217	Ubiquitination	GADAVDVMAGIPWEL CCCHHHHHCCCCCHH	2.15	23503661
233	Acetylation	CPKVIGVKLTGSLSG CCCEEEEEEEECCCC	34.81	25038526
233	Succinylation	CPKVIGVKLTGSLSG CCCEEEEEEEECCCC	34.81	-
233	Succinylation	CPKVIGVKLTGSLSG CCCEEEEEEEECCCC	34.81	-
237	Phosphorylation	IGVKLTGSLSGWSSP EEEEEEECCCCCCCH	17.71	9543159
239	Phosphorylation	VKLTGSLSGWSSPKD EEEEECCCCCCCHHH	39.66	28857561
242	Phosphorylation	TGSLSGWSSPKDVIL EECCCCCCCHHHHHE	40.04	110757319
243	Phosphorylation	GSLSGWSSPKDVILK ECCCCCCCHHHHHEE	29.47	9543171
245	Ubiquitination	LSGWSSPKDVILKVA CCCCCCHHHHHEEEE	67.58	23503661
250	Ubiquitination	SPKDVILKVAGILTV CHHHHHEEEEEEEEE	20.93	23503661
276	Ubiquitination	GPGVDSISCTGMATI CCCCCCCEECCCHHH	15.02	24816145
309	Ubiquitination	RMKKYLSKTGREDIA HHHHHHHHHCHHHHH	53.02	24816145
310	Phosphorylation	MKKYLSKTGREDIAN HHHHHHHHCHHHHHH	37.79	62150913
333	Ubiquitination	LVPDPGCHYDQLIEI CCCCCCCCHHHEEEE	34.81	22817900
337	Ubiquitination	PGCHYDQLIEINLSE CCCCHHHEEEEEHHH	3.29	21890473
366	Ubiquitination	HPVAEVGKVAEKEGW CCHHHHHHHHHHHCC	43.37	22817900
368	Ubiquitination	VAEVGKVAEKEGWPL HHHHHHHHHHHCCCC	26.15	23503661
370	Acetylation	EVGKVAEKEGWPLDI HHHHHHHHHCCCCEE	52.36	23954790
370	Ubiquitination	EVGKVAEKEGWPLDI HHHHHHHHHCCCCEE	52.36	22817900
385	Glutathionylation	RVGLIGSCTNSSYED EEEEEECCCCCCHHH	3.35	22555962
390	Phosphorylation	GSCTNSSYEDMGRSA ECCCCCCHHHHHHHH	18.77	46157839
401	Acetylation	GRSAAVAKQALAHGL HHHHHHHHHHHHCCC	29.52	25953088
401	Succinylation	GRSAAVAKQALAHGL HHHHHHHHHHHHCCC	29.52	23954790
401	Ubiquitination	GRSAAVAKQALAHGL HHHHHHHHHHHHCCC	29.52	23503661
409	Ubiquitination	QALAHGLKCKSQFTI HHHHCCCCCEEEEEE	44.18	29967540
410	S-nitrosylation	ALAHGLKCKSQFTIT HHHCCCCCEEEEEEC	6.53	24105792
411	Succinylation	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	-
411	Succinylation	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	-
411	Ubiquitination	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	-
432	Phosphorylation	ATIERDGYAQILRDL EEEECCCHHHHHHHC	10.30	46157851
432	Ubiquitination	ATIERDGYAQILRDL EEEECCCHHHHHHHC	10.30	24816145
462	Acetylation	WDRKDIKKGEKNTIV CCHHHHCCCCCCEEE	73.05	25953088
462	Ubiquitination	WDRKDIKKGEKNTIV CCHHHHCCCCCCEEE	73.05	29967540
465	Acetylation	KDIKKGEKNTIVTSY HHHCCCCCCEEEEEE	68.97	25953088
465	Ubiquitination	KDIKKGEKNTIVTSY HHHCCCCCCEEEEEE	68.97	24816145
467	Phosphorylation	IKKGEKNTIVTSYNR HCCCCCCEEEEEEEC	28.08	20860994
470	Phosphorylation	GEKNTIVTSYNRNFT CCCCEEEEEEECCCC	22.95	28152594
471	Phosphorylation	EKNTIVTSYNRNFTG CCCEEEEEEECCCCC	14.98	28152594
472	Nitration	KNTIVTSYNRNFTGR CCEEEEEEECCCCCC	14.58	-
472	Phosphorylation	KNTIVTSYNRNFTGR CCEEEEEEECCCCCC	14.58	28152594
474	Methylation	TIVTSYNRNFTGRND EEEEEEECCCCCCCC	31.26	-
477	Phosphorylation	TSYNRNFTGRNDANP EEEECCCCCCCCCCC	38.49	7687187
487	Ubiquitination	NDANPETHAFVTSPE CCCCCCCEEEECCHH	18.60	23503661
488	Ubiquitination	DANPETHAFVTSPEI CCCCCCEEEECCHHH	14.18	23503661
513	Phosphorylation	KFNPETDYLTGTDGK CCCCCCCEEECCCCC	17.37	119329
515	Phosphorylation	NPETDYLTGTDGKKF CCCCCEEECCCCCEE	31.63	110757331
520	2-Hydroxyisobutyrylation	YLTGTDGKKFRLEAP EEECCCCCEEEEECC	52.10	-
520	Acetylation	YLTGTDGKKFRLEAP EEECCCCCEEEEECC	52.10	23954790
520	Malonylation	YLTGTDGKKFRLEAP EEECCCCCEEEEECC	52.10	26320211
520	Succinylation	YLTGTDGKKFRLEAP EEECCCCCEEEEECC	52.10	27452117
520	Ubiquitination	YLTGTDGKKFRLEAP EEECCCCCEEEEECC	52.10	23503661
521	Acetylation	LTGTDGKKFRLEAPD EECCCCCEEEEECCC	41.04	7624281
521	Ubiquitination	LTGTDGKKFRLEAPD EECCCCCEEEEECCC	41.04	23503661
523	Methylation	GTDGKKFRLEAPDAD CCCCCEEEEECCCHH	40.26	-
534	Acetylation	PDADELPKGEFDPGQ CCHHHCCCCCCCCCC	81.39	23236377
534	Succinylation	PDADELPKGEFDPGQ CCHHHCCCCCCCCCC	81.39	27452117
534	Ubiquitination	PDADELPKGEFDPGQ CCHHHCCCCCCCCCC	81.39	29967540
543	Phosphorylation	EFDPGQDTYQHPPKD CCCCCCCCCCCCCCC	19.73	110757343
544	Phosphorylation	FDPGQDTYQHPPKDS CCCCCCCCCCCCCCC	17.08	2917121
549	Acetylation	DTYQHPPKDSSGQHV CCCCCCCCCCCCCCC	74.76	20167786
549	Malonylation	DTYQHPPKDSSGQHV CCCCCCCCCCCCCCC	74.76	26320211
549	Succinylation	DTYQHPPKDSSGQHV CCCCCCCCCCCCCCC	74.76	-
549	Succinylation	DTYQHPPKDSSGQHV CCCCCCCCCCCCCCC	74.76	-
551	Phosphorylation	YQHPPKDSSGQHVDV CCCCCCCCCCCCCCC	42.36	29396449
552	Phosphorylation	QHPPKDSSGQHVDVS CCCCCCCCCCCCCCC	53.24	29255136
559	Phosphorylation	SGQHVDVSPTSQRLQ CCCCCCCCCHHHHHH	20.28	29255136
561	Phosphorylation	QHVDVSPTSQRLQLL CCCCCCCHHHHHHHC	29.95	29255136
562	Phosphorylation	HVDVSPTSQRLQLLE CCCCCCHHHHHHHCC	19.38	25159151
573	2-Hydroxyisobutyrylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	-
573	Acetylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	19608861
573	Succinylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	-
573	Succinylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	-
573	Ubiquitination	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	19608861
577	Acetylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	25038526
577	Succinylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	-
577	Succinylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	-
591	Malonylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	26320211
591	Succinylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	-
591	Succinylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	-
592	S-nitrosocysteine	LIKVKGKCTTDHISA EEEECCEECCCCHHC	7.26	-
592	Glutathionylation	LIKVKGKCTTDHISA EEEECCEECCCCHHC	7.26	22555962
592	S-nitrosylation	LIKVKGKCTTDHISA EEEECCEECCCCHHC	7.26	22178444
605	Acetylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	19608861
605	Malonylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	26320211
605	Succinylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	-
605	Succinylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	-
605	Ubiquitination	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	19608861
628	Acetylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	25038526
628	Succinylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	-
628	Succinylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	-
646	Phosphorylation	EFGPVPDTARYYKKH HCCCCCCHHHHHHHH	13.63	110757355
656	Ubiquitination	YYKKHGIRWVVIGDE HHHHHCCEEEEECCC	25.40	27667366
665	Phosphorylation	VVIGDENYGEGSSRE EEECCCCCCCCCCCC	17.95	2917113
667	Ubiquitination	IGDENYGEGSSREHA ECCCCCCCCCCCCCC	45.61	23503661
668	Ubiquitination	GDENYGEGSSREHAA CCCCCCCCCCCCCCC	26.93	23503661
669	Phosphorylation	DENYGEGSSREHAAL CCCCCCCCCCCCCCC	23.17	28857561
670	Phosphorylation	ENYGEGSSREHAALE CCCCCCCCCCCCCCC	53.17	28857561
679	Methylation	EHAALEPRHLGGRAI CCCCCCCCHHCCCEE	28.43	-
684	Ubiquitination	EPRHLGGRAIITKSF CCCHHCCCEEEEHHH	22.33	23503661
689	2-Hydroxyisobutyrylation	GGRAIITKSFARIHE CCCEEEEHHHHHHHH	32.92	-
689	Acetylation	GGRAIITKSFARIHE CCCEEEEHHHHHHHH	32.92	25825284
689	Succinylation	GGRAIITKSFARIHE CCCEEEEHHHHHHHH	32.92	-
689	Succinylation	GGRAIITKSFARIHE CCCEEEEHHHHHHHH	32.92	-
689	Ubiquitination	GGRAIITKSFARIHE CCCEEEEHHHHHHHH	32.92	27667366
690	Ubiquitination	GRAIITKSFARIHET CCEEEEHHHHHHHHH	18.58	23503661
697	Ubiquitination	SFARIHETNLKKQGL HHHHHHHHCCHHCCC	31.52	23000965
700	2-Hydroxyisobutyrylation	RIHETNLKKQGLLPL HHHHHCCHHCCCCCC	45.16	-
700	Acetylation	RIHETNLKKQGLLPL HHHHHCCHHCCCCCC	45.16	25953088
700	Ubiquitination	RIHETNLKKQGLLPL HHHHHCCHHCCCCCC	45.16	23503661
701	Ubiquitination	IHETNLKKQGLLPLT HHHHCCHHCCCCCCE	53.41	23503661
703	Ubiquitination	ETNLKKQGLLPLTFA HHCCHHCCCCCCEEC	37.75	23000965
708	Phosphorylation	KQGLLPLTFADPADY HCCCCCCEECCHHHC	18.16	22210691
715	Phosphorylation	TFADPADYNKIHPVD EECCHHHCCCCCCCC	22.06	22210691
717	Ubiquitination	ADPADYNKIHPVDKL CCHHHCCCCCCCCEE	35.84	23503661
723	Acetylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	25038526
723	Succinylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	-
723	Succinylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	-
723	Ubiquitination	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	23503661
730	Acetylation	KLTIQGLKDFTPGKP EEEECCCCCCCCCCC	58.58	25038526
730	Malonylation	KLTIQGLKDFTPGKP EEEECCCCCCCCCCC	58.58	26320211
730	Succinylation	KLTIQGLKDFTPGKP EEEECCCCCCCCCCC	58.58	-
730	Succinylation	KLTIQGLKDFTPGKP EEEECCCCCCCCCCC	58.58	27452117
730	Ubiquitination	KLTIQGLKDFTPGKP EEEECCCCCCCCCCC	58.58	23000965
736	Acetylation	LKDFTPGKPLKCIIK CCCCCCCCCEEEEEE	48.67	25953088
736	Malonylation	LKDFTPGKPLKCIIK CCCCCCCCCEEEEEE	48.67	26320211
736	Succinylation	LKDFTPGKPLKCIIK CCCCCCCCCEEEEEE	48.67	23954790
736	Ubiquitination	LKDFTPGKPLKCIIK CCCCCCCCCEEEEEE	48.67	23000965
739	Acetylation	FTPGKPLKCIIKHPN CCCCCCEEEEEECCC	31.73	25953088
739	Malonylation	FTPGKPLKCIIKHPN CCCCCCEEEEEECCC	31.73	26320211
743	Acetylation	KPLKCIIKHPNGTQE CCEEEEEECCCCCEE	32.85	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACON_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACON_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACON_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KAD3_HUMAN	AK3	physical	22939629
THIL_HUMAN	ACAT1	physical	22939629
SIN3A_HUMAN	SIN3A	physical	22939629
THIM_HUMAN	ACAA2	physical	22939629
SSDH_HUMAN	ALDH5A1	physical	26344197
ALDOA_HUMAN	ALDOA	physical	26344197
ALDOC_HUMAN	ALDOC	physical	26344197
AT1B1_HUMAN	ATP1B1	physical	26344197
AT5F1_HUMAN	ATP5F1	physical	26344197
ATP5J_HUMAN	ATP5J	physical	26344197
ESTD_HUMAN	ESD	physical	26344197
GPDA_HUMAN	GPD1	physical	26344197
GPD1L_HUMAN	GPD1L	physical	26344197
GPDM_HUMAN	GPD2	physical	26344197
PIPNB_HUMAN	PITPNB	physical	26344197
VAPA_HUMAN	VAPA	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614559: Infantile cerebellar-retinal degeneration (ICRD)
• 616289: Optic atrophy 8 (OPA8)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-50; LYS-573 AND LYS-605, ANDMASS SPECTROMETRY.
PubMed: 19608861