KAD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAD3_HUMAN
• UniProt AC: Q9UIJ7
• Protein Name: GTP:AMP phosphotransferase AK3, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03169}
• Gene Name: AK3 {ECO:0000255|HAMAP-Rule:MF_03169}
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities..
• Protein Sequence: MGASARLLRAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPDDVMTRLALHELKNLTQYSWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTETNKIWPYVYAFLQTKVPQRSQKASVTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGASARLLRAV ----CCHHHHHHHHH	14.27	24719451
18	Phosphorylation	VIMGAPGSGKGTVSS HHHCCCCCCCCCCCC	35.95	28857561
20	Succinylation	MGAPGSGKGTVSSRI HCCCCCCCCCCCCCE	53.78	23954790
20	Succinylation	MGAPGSGKGTVSSRI HCCCCCCCCCCCCCE	53.78	-
20	Acetylation	MGAPGSGKGTVSSRI HCCCCCCCCCCCCCE	53.78	2402139
20	Malonylation	MGAPGSGKGTVSSRI HCCCCCCCCCCCCCE	53.78	26320211
22	Phosphorylation	APGSGKGTVSSRITT CCCCCCCCCCCCEEC	22.24	28857561
24	Phosphorylation	GSGKGTVSSRITTHF CCCCCCCCCCEECCE	17.46	28857561
25	Phosphorylation	SGKGTVSSRITTHFE CCCCCCCCCEECCEE	24.30	24719451
34	Acetylation	ITTHFELKHLSSGDL EECCEEEECCCCCCH	34.99	25825284
34	Malonylation	ITTHFELKHLSSGDL EECCEEEECCCCCCH	34.99	26320211
37	Phosphorylation	HFELKHLSSGDLLRD CEEEECCCCCCHHHH	31.81	28450419
38	Phosphorylation	FELKHLSSGDLLRDN EEEECCCCCCHHHHC	42.56	30108239
48	Methylation	LLRDNMLRGTEIGVL HHHHCCCCCCHHHHH	38.94	-
57	Acetylation	TEIGVLAKAFIDQGK CHHHHHHHHHHHCCC	39.40	25953088
57	Succinylation	TEIGVLAKAFIDQGK CHHHHHHHHHHHCCC	39.40	-
57	Succinylation	TEIGVLAKAFIDQGK CHHHHHHHHHHHCCC	39.40	-
64	Malonylation	KAFIDQGKLIPDDVM HHHHHCCCCCCHHHH	37.30	26320211
64	Succinylation	KAFIDQGKLIPDDVM HHHHHCCCCCCHHHH	37.30	-
64	Acetylation	KAFIDQGKLIPDDVM HHHHHCCCCCCHHHH	37.30	-
64	Succinylation	KAFIDQGKLIPDDVM HHHHHCCCCCCHHHH	37.30	-
72	Phosphorylation	LIPDDVMTRLALHEL CCCHHHHHHHHHHHH	23.52	20068231
80	Succinylation	RLALHELKNLTQYSW HHHHHHHHHHHHHHH	47.10	-
80	Acetylation	RLALHELKNLTQYSW HHHHHHHHHHHHHHH	47.10	-
80	Succinylation	RLALHELKNLTQYSW HHHHHHHHHHHHHHH	47.10	-
85	Phosphorylation	ELKNLTQYSWLLDGF HHHHHHHHHHHHHCC	9.14	20562437
138	Phosphorylation	HPASGRVYNIEFNPP ECCCCCEEEEEECCC	14.73	21406692
147	Phosphorylation	IEFNPPKTVGIDDLT EEECCCCCCCCCCCC	29.73	21406692
154	Phosphorylation	TVGIDDLTGEPLIQR CCCCCCCCCCCCEEC	46.63	21406692
165	Acetylation	LIQREDDKPETVIKR CEECCCCCCHHHHHH	58.01	23954790
174	Malonylation	ETVIKRLKAYEDQTK HHHHHHHHHHCCCCH	53.61	26320211
174	Succinylation	ETVIKRLKAYEDQTK HHHHHHHHHHCCCCH	53.61	-
174	Succinylation	ETVIKRLKAYEDQTK HHHHHHHHHHCCCCH	53.61	-
174	Acetylation	ETVIKRLKAYEDQTK HHHHHHHHHHCCCCH	53.61	-
176	Phosphorylation	VIKRLKAYEDQTKPV HHHHHHHHCCCCHHH	20.60	29496907
181	Ubiquitination	KAYEDQTKPVLEYYQ HHHCCCCHHHHHHHH	27.74	-
181	Acetylation	KAYEDQTKPVLEYYQ HHHCCCCHHHHHHHH	27.74	20167786
181	Succinylation	KAYEDQTKPVLEYYQ HHHCCCCHHHHHHHH	27.74	23954790
181	Malonylation	KAYEDQTKPVLEYYQ HHHCCCCHHHHHHHH	27.74	26320211
186	Phosphorylation	QTKPVLEYYQKKGVL CCHHHHHHHHHHCCE	13.67	119557
189	Succinylation	PVLEYYQKKGVLETF HHHHHHHHHCCEECC	35.06	-
189	Succinylation	PVLEYYQKKGVLETF HHHHHHHHHCCEECC	35.06	23954790
189	Acetylation	PVLEYYQKKGVLETF HHHHHHHHHCCEECC	35.06	23236377
190	Acetylation	VLEYYQKKGVLETFS HHHHHHHHCCEECCC	38.43	6271573
197	Phosphorylation	KGVLETFSGTETNKI HCCEECCCCCCCCCH	52.83	110760127
203	Acetylation	FSGTETNKIWPYVYA CCCCCCCCHHHHHHH	54.27	-
207	Phosphorylation	ETNKIWPYVYAFLQT CCCCHHHHHHHHHHC	7.35	46161143
209	Phosphorylation	NKIWPYVYAFLQTKV CCHHHHHHHHHHCCC	5.94	46161149
220	Phosphorylation	QTKVPQRSQKASVTP HCCCCCHHHCCCCCC	30.68	26437602
224	Phosphorylation	PQRSQKASVTP---- CCHHHCCCCCC----	33.29	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAPK3_HUMAN	DAPK3	physical	21988832
CAF17_HUMAN	IBA57	physical	26186194
HNRL2_HUMAN	HNRNPUL2	physical	26344197
RS14_HUMAN	RPS14	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-34, AND MASS SPECTROMETRY.
PubMed: 19608861