AA1R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AA1R_HUMAN
• UniProt AC: P30542
• Protein Name: Adenosine receptor A1
• Gene Name: ADORA1
• Organism: Homo sapiens (Human).
• Sequence Length: 326
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein.
• Protein Description: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase..
• Protein Sequence: MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	N-linked_Glycosylation	VERAWAANGSMGEPV HHHHHHHCCCCCCCE	35.01	UniProtKB CARBOHYD
214	"N6,N6-dimethyllysine"	IRKQLNKKVSASSGD HHHHHCCCCCCCCCC	40.11	-
214	Methylation	IRKQLNKKVSASSGD HHHHHCCCCCCCCCC	40.11	-
224	"N6,N6-dimethyllysine"	ASSGDPQKYYGKELK CCCCCHHHHHHHHHH	45.91	-
224	Methylation	ASSGDPQKYYGKELK CCCCCHHHHHHHHHH	45.91	-
309	S-palmitoylation	IWNDHFRCQPAPPID HHCCCCCCCCCCCCC	5.78	10455026

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AA1R_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AA1R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AA1R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DRD1_HUMAN	DRD1	physical	10890919
GNAI2_HUMAN	GNAI2	physical	11369591
SNF8_HUMAN	SNF8	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00045: Adenosine (JAN/USP); Adenocard (TN); Adenoscan (TN)
• D00227: Aminophylline (USP/INN); Somophyllin (TN); Theophylline ethylenediamine (TN)
• D00371: Theophylline (JP16); Elixophyllin (TN); Quibron-t (TN); Theo-24 (TN); Theodur G (TN); Theolair (TN);
• D00528: Anhydrous caffeine (JP16); Caffeine (USP); Anhydrous caffeine (TN)
• D01453: Caffeine hydrate (JP16); Caffeine monohydrate; Caffeine (TN)
• D01712: Theophylline sodium acetate (JAN)
• D01771: Proxyphylline (JAN/INN); Monophyllin (TN)
• D02017: Choline theophylline (JAN); Oxtriphylline (USP); Choline theophyllinate (INN); Theophyline - choline
• D02964: Apaxifylline (USAN/INN)
• D03051: Bamifylline hydrochloride (USAN)
• D03898: Doxofylline (USAN/INN); Maxivent (TN)
• D04006: Enprofylline (USAN/INN)
• D05429: Aminophylline hydrate (JP16)
• D05818: Selodenoson (USAN/INN)
• D06019: Tecadenoson (USAN/INN)
• D06103: Theophylline (USP); Theophylline monohydrate; Accurbron (TN)
• D06104: Theophylline sodium glycinate (USP); Asbron (TN)
• D07491: Bamifylline (INN)
• D07603: Caffeine citrate (USP); Cafcit (TN)
• D08989: Rolofylline (USAN)
• D09684: Tonapofylline (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.