MBD6_HUMAN - dbPTM
MBD6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MBD6_HUMAN
UniProt AC Q96DN6
Protein Name Methyl-CpG-binding domain protein 6
Gene Name MBD6
Organism Homo sapiens (Human).
Sequence Length 1003
Subcellular Localization Nucleus . Chromosome . Associated with pericentric heterochromatin in about 25% of the cells.
Protein Description Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro)..
Protein Sequence MNGGNESSGADRAGGPVATSVPIGWQRCVREGAVLYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGPLLSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGLRGINGEARPARGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTARAAVPLPPRARPGRPAKNKRRKLAP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
116PhosphorylationAMATLYRSMETTCSH
HHHHHHHHHHHHCCC		13.8627080861
119PhosphorylationTLYRSMETTCSHSSP
HHHHHHHHHCCCCCC		25.1827080861
120PhosphorylationLYRSMETTCSHSSPG
HHHHHHHHCCCCCCC		9.9427080861
122PhosphorylationRSMETTCSHSSPGEG
HHHHHHCCCCCCCCC		25.0627080861
124PhosphorylationMETTCSHSSPGEGAS
HHHHCCCCCCCCCCC		23.1827080861
125PhosphorylationETTCSHSSPGEGASP
HHHCCCCCCCCCCCC		31.3427080861
131PhosphorylationSSPGEGASPQMFHTV
CCCCCCCCCCCEEEC		26.9027080861
137PhosphorylationASPQMFHTVSPGPPS
CCCCCEEECCCCCCC		16.0627080861
139PhosphorylationPQMFHTVSPGPPSAR
CCCEEECCCCCCCCC		25.8727080861
144PhosphorylationTVSPGPPSARPPCRV
ECCCCCCCCCCCCCC		39.7927080861
195PhosphorylationRLADPVPSGGSSSPR
CCCCCCCCCCCCCCC		56.8929396449
198PhosphorylationDPVPSGGSSSPRFLP
CCCCCCCCCCCCCCC		31.0329396449
199PhosphorylationPVPSGGSSSPRFLPR
CCCCCCCCCCCCCCC		47.8629396449
200PhosphorylationVPSGGSSSPRFLPRG
CCCCCCCCCCCCCCC		23.0729396449
211PhosphorylationLPRGNAPSPAPPPPP
CCCCCCCCCCCCCCC		31.1424719451
379MethylationVFRLLEGRGPQTPRR
HHHHHCCCCCCCCCC		44.2283108353
387PhosphorylationGPQTPRRSRPRAPAP
CCCCCCCCCCCCCCC		48.1717081983
896MethylationLALKWGTRGGFNGQM
EEECCCCCCCCCCCC		39.0230760355
906PhosphorylationFNGQMERSPRRTHHW
CCCCCCCCCCCCCCC		14.9527251275
956AcetylationSRRGRRRKYNPTRNS
CCCCCCCCCCCCCCC		47.7920167786
963PhosphorylationKYNPTRNSNSSRQDI
CCCCCCCCCCCCCCC		34.4922210691
965PhosphorylationNPTRNSNSSRQDITL
CCCCCCCCCCCCCEE		27.0722210691
971PhosphorylationNSSRQDITLEPSPTA
CCCCCCCEECCCCCC		33.1030266825
975PhosphorylationQDITLEPSPTARAAV
CCCEECCCCCCCCCC		26.0530266825
977PhosphorylationITLEPSPTARAAVPL
CEECCCCCCCCCCCC		32.8730266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MBD6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MBD6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MBD6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MBD6_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MBD6_HUMAN

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Related Literatures of Post-Translational Modification

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