GAS7_HUMAN - dbPTM
GAS7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GAS7_HUMAN
UniProt AC O60861
Protein Name Growth arrest-specific protein 7
Gene Name GAS7
Organism Homo sapiens (Human).
Sequence Length 476
Subcellular Localization Cytoplasm.
Protein Description May play a role in promoting maturation and morphological differentiation of cerebellar neurons..
Protein Sequence MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74PhosphorylationPPPPGEESQTVILPP
CCCCCCCCCEEEECC		27.1824043423
76PhosphorylationPPGEESQTVILPPGW
CCCCCCCEEEECCCH		20.8424043423
85PhosphorylationILPPGWQSYLSPQGR
EECCCHHHEECCCCC		22.8724043423
86PhosphorylationLPPGWQSYLSPQGRR
ECCCHHHEECCCCCE		8.9724043423
88PhosphorylationPGWQSYLSPQGRRYY
CCHHHEECCCCCEEE		13.6224043423
94PhosphorylationLSPQGRRYYVNTTTN
ECCCCCEEEEECCCC		15.4827251275
95PhosphorylationSPQGRRYYVNTTTNE
CCCCCEEEEECCCCC		5.8427251275
95UbiquitinationSPQGRRYYVNTTTNE
CCCCCEEEEECCCCC		5.8430230243
98PhosphorylationGRRYYVNTTTNETTW
CCEEEEECCCCCCCC		25.5929116813
99PhosphorylationRRYYVNTTTNETTWE
CEEEEECCCCCCCCC		23.5529116813
100PhosphorylationRYYVNTTTNETTWER
EEEEECCCCCCCCCC		29.0830576142
103PhosphorylationVNTTTNETTWERPSS
EECCCCCCCCCCCCC		39.0030301811
104PhosphorylationNTTTNETTWERPSSS
ECCCCCCCCCCCCCC		21.1026657352
106UbiquitinationTTNETTWERPSSSPG
CCCCCCCCCCCCCCC		53.2530230243
109PhosphorylationETTWERPSSSPGIPA
CCCCCCCCCCCCCCC		50.0629255136
110PhosphorylationTTWERPSSSPGIPAS
CCCCCCCCCCCCCCC		43.1429255136
111PhosphorylationTWERPSSSPGIPASP
CCCCCCCCCCCCCCC		31.3328464451
117PhosphorylationSSPGIPASPGSHRSS
CCCCCCCCCCCCCCC		25.1729255136
117UbiquitinationSSPGIPASPGSHRSS
CCCCCCCCCCCCCCC		25.1729967540
120PhosphorylationGIPASPGSHRSSLPP
CCCCCCCCCCCCCCC		21.0729255136
128PhosphorylationHRSSLPPTVNGYHAS
CCCCCCCCCCCCCCC		25.3523879269
135PhosphorylationTVNGYHASGTPAHPP
CCCCCCCCCCCCCCC		29.8623879269
139UbiquitinationYHASGTPAHPPETAH
CCCCCCCCCCCCCCE		27.8829967540
140UbiquitinationHASGTPAHPPETAHM
CCCCCCCCCCCCCEE		39.3830230243
144PhosphorylationTPAHPPETAHMSVRK
CCCCCCCCCEEEEEC		27.8623879269
148PhosphorylationPPETAHMSVRKSTGD
CCCCCEEEEECCCCC		14.6523879269
152PhosphorylationAHMSVRKSTGDSQNL
CEEEEECCCCCCCCC		27.3623911959
153PhosphorylationHMSVRKSTGDSQNLG
EEEEECCCCCCCCCC		48.3026657352
156PhosphorylationVRKSTGDSQNLGSSS
EECCCCCCCCCCCCC		23.4724702127
161PhosphorylationGDSQNLGSSSPSKKQ
CCCCCCCCCCCCCCC		30.7024702127
162PhosphorylationDSQNLGSSSPSKKQS
CCCCCCCCCCCCCCC		44.4629255136
162UbiquitinationDSQNLGSSSPSKKQS
CCCCCCCCCCCCCCC		44.4630230243
163PhosphorylationSQNLGSSSPSKKQSK
CCCCCCCCCCCCCCC		34.5829255136
165PhosphorylationNLGSSSPSKKQSKEN
CCCCCCCCCCCCCCC		55.2029255136
169PhosphorylationSSPSKKQSKENTITI
CCCCCCCCCCCEEEE		51.3126074081
171UbiquitinationPSKKQSKENTITINC
CCCCCCCCCEEEEEE		65.9230230243
173PhosphorylationKKQSKENTITINCVT
CCCCCCCEEEEEEEE		22.1626074081
175PhosphorylationQSKENTITINCVTFP
CCCCCEEEEEEEEEC		12.2326074081
175UbiquitinationQSKENTITINCVTFP
CCCCCEEEEEEEEEC		12.2330230243
177UbiquitinationKENTITINCVTFPHP
CCCEEEEEEEEECCC		12.9330230243
180PhosphorylationTITINCVTFPHPDTM
EEEEEEEEECCCCCC		33.3826074081
182UbiquitinationTINCVTFPHPDTMPE
EEEEEEECCCCCCCH		28.8330230243
186UbiquitinationVTFPHPDTMPEQQLL
EEECCCCCCCHHHCC		38.7930230243
193UbiquitinationTMPEQQLLKPTEWSY
CCCHHHCCCCCCCCC		5.6229967540
197UbiquitinationQQLLKPTEWSYCDYF
HHCCCCCCCCCCCEE		42.8429967540
213UbiquitinationADKKDPQGNGTVAGF
ECCCCCCCCCCCCHH		39.6630230243
215UbiquitinationKKDPQGNGTVAGFEL
CCCCCCCCCCCHHHH		28.5229967540
216UbiquitinationKDPQGNGTVAGFELL
CCCCCCCCCCHHHHH		15.9330230243
219UbiquitinationQGNGTVAGFELLLQK
CCCCCCCHHHHHHHH		16.5429967540
220UbiquitinationGNGTVAGFELLLQKQ
CCCCCCHHHHHHHHH		4.2730230243
235UbiquitinationLKGKQMQKEMSEFIR
HCCHHHHHHHHHHHH		50.4730230243
238UbiquitinationKQMQKEMSEFIRERI
HHHHHHHHHHHHHHH		30.3730230243
242UbiquitinationKEMSEFIRERIKIEE
HHHHHHHHHHHHCCH		32.2530230243
246UbiquitinationEFIRERIKIEEDYAK
HHHHHHHHCCHHHHH		50.7330230243
253UbiquitinationKIEEDYAKNLAKLSQ
HCCHHHHHHHHHHHH		46.3930230243
257UbiquitinationDYAKNLAKLSQNSLA
HHHHHHHHHHHHHHH		52.4130230243
279UbiquitinationGEAWAQVKKSLADEA
HHHHHHHHHHHCCCC		25.2729967540
280UbiquitinationEAWAQVKKSLADEAE
HHHHHHHHHHCCCCE		52.4230230243
289UbiquitinationLADEAEVHLKFSAKL
HCCCCEEHHHHHHHH		18.1430230243
293UbiquitinationAEVHLKFSAKLHSEV
CEEHHHHHHHHHHHH		23.9430230243
296UbiquitinationHLKFSAKLHSEVEKP
HHHHHHHHHHHHHHH		5.5529967540
300UbiquitinationSAKLHSEVEKPLMNF
HHHHHHHHHHHHHHH		14.8929967540
302UbiquitinationKLHSEVEKPLMNFRE
HHHHHHHHHHHHHHH		48.9430230243
302AcetylationKLHSEVEKPLMNFRE
HHHHHHHHHHHHHHH		48.9425953088
311UbiquitinationLMNFRENFKKDMKKC
HHHHHHHHHHHHHHC		9.9730230243
315UbiquitinationRENFKKDMKKCDHHI
HHHHHHHHHHCHHHH		6.4930230243
317UbiquitinationNFKKDMKKCDHHIAD
HHHHHHHHCHHHHHH		37.9530230243
331PhosphorylationDLRKQLASRYASVEK
HHHHHHHHHHHHHHH		34.12-
333PhosphorylationRKQLASRYASVEKAR
HHHHHHHHHHHHHHH		10.75-
335PhosphorylationQLASRYASVEKARKA
HHHHHHHHHHHHHHH		23.1324719451
353UbiquitinationRQRDLEMKTQQLEIK
HHHHHHHHHHHHHHH		33.5330230243
360UbiquitinationKTQQLEIKLSNKTEE
HHHHHHHHHCCCCHH		36.1729967540
375UbiquitinationDIKKARRKSTQAGDD
HHHHHHHHHHHHCHH		52.9130230243
376PhosphorylationIKKARRKSTQAGDDL
HHHHHHHHHHHCHHH		24.7629255136
377PhosphorylationKKARRKSTQAGDDLM
HHHHHHHHHHCHHHH		26.0229255136
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GAS7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GAS7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GAS7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GAS7_HUMANGAS7physical
12957285
HNRPU_HUMANHNRNPUphysical
16055720
KHDR1_HUMANKHDRBS1physical
16055720
SF01_HUMANSF1physical
16055720
SF3A1_HUMANSF3A1physical
16055720
SFPQ_HUMANSFPQphysical
16055720
RLA0_HUMANRPLP0physical
16055720
ABI1_HUMANABI1physical
16055720
CYFP1_HUMANCYFIP1physical
16055720
CYFP2_HUMANCYFIP2physical
16055720
DIAP1_HUMANDIAPH1physical
16055720
FMNL1_HUMANFMNL1physical
16055720
WASP_HUMANWASphysical
16055720
WASF2_HUMANWASF2physical
16055720
AB1IP_HUMANAPBB1IPphysical
16055720
NCKP1_HUMANNCKAP1physical
16055720
NCKPL_HUMANNCKAP1Lphysical
16055720
G3P_HUMANGAPDHphysical
16055720
GAS7_HUMANGAS7physical
25416956
NTAQ1_HUMANWDYHV1physical
25416956
WASP_HUMANWASphysical
26506240
HNRPU_HUMANHNRNPUphysical
26506240
GAS7_HUMANGAS7physical
26702831
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GAS7_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND MASSSPECTROMETRY.

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