NCKPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCKPL_HUMAN
• UniProt AC: P55160
• Protein Name: Nck-associated protein 1-like {ECO:0000305}
• Gene Name: NCKAP1L {ECO:0000312|HGNC:HGNC:4862}
• Organism: Homo sapiens (Human).
• Sequence Length: 1127
• Subcellular Localization: Cell membrane ; Single-pass membrane protein ; Cytoplasmic side . Cytoplasm . Localizes to the leading edge of polarized neutrophils.
• Protein Description: Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. [PubMed: 16417406]
• Protein Sequence: MSLTSAYQHKLAEKLTILNDRGQGVLIRMYNIKKTCSDPKSKPPFLLEKSMEPSLKYINKKFPNIDVRNSTQHLGPVHREKAEIIRFLTNYYQSFVDVMEFRDHVYELLNTIDACQCHFDINLNFDFTRSYLDLIVTYTSVILLLSRIEDRRILIGMYNCAHEMLHGHGDPSFARLGQMVLEYDHPLKKLTEEFGPHTKAVSGALLSLHFLFVRRNQGAEQWRSAQLLSLISNPPAMINPANSDTMACEYLSVEVMERWIIIGFLLCHGCLNSNSQCQKLWKLCLQGSLYITLIREDVLQVHKVTEDLFSSLKGYGKRVADIKESKEHVIANSGQFHCQRRQFLRMAVKELETVLADEPGLLGPKALFAFMALSFIRDEVTWLVRHTENVTKTKTPEDYADSSIAELLFLLEGIRSLVRRHIKVIQQYHLQYLARFDALVLSDIIQNLSVCPEEESIIMSSFVSILSSLNLKQVDNGEKFEFSGLRLDWFRLQAYTSVAKAPLHLHENPDLAKVMNLIVFHSRMLDSVEKLLVETSDLSTFCFHLRIFEKMFAMTLEESAMLRYAIAFPLICAHFVHCTHEMCPEEYPHLKNHGLHHCNSFLEELAKQTSNCVLEICAEQRNLSEQLLPKHCATTISKAKNKKTRKQRQTPRKGEPERDKPGAESHRKNRSIVTNMDKLHLNLTELALTMNHVYSFSVFEHTIFPSEYLSSHLEARLNRAIVWLAGYNATTQEIVRPSELLAGVKAYIGFIQSLAQFLGADASRVIRNALLQQTQPLDSCGEQTITTLYTNWYLESLLRQASSGTIILSPAMQAFVSLPREGEQNFSAEEFSDISEMRALAELLGPYGMKFLSENLMWHVTSQIVELKKLVVENMDILVQIRSNFSKPDLMASLLPQLTGAENVLKRMTIIGVILSFRAMAQEGLREVFSSHCPFLMGPIECLKEFVTPDTDIKVTLSIFELASAAGVGCDIDPALVAAIANLKADTSSPEEEYKVACLLLIFLAVSLPLLATDPSSFYSIEKDGYNNNIHCLTKAIIQVSAALFTLYNKNIETHLKEFLVVASVSLLQLGQETDKLKTRNRESISLLMRLVVEESSFLTLDMLESCFPYVLLRNAYREVSRAFHLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLTSAYQH ------CCHHHHHHH	52.22	28450419
4	Phosphorylation	----MSLTSAYQHKL ----CCHHHHHHHHH	22.17	21949786
5	Phosphorylation	---MSLTSAYQHKLA ---CCHHHHHHHHHH	30.21	21949786
6	Ubiquitination	--MSLTSAYQHKLAE --CCHHHHHHHHHHH	11.63	22817900
10	Acetylation	LTSAYQHKLAEKLTI HHHHHHHHHHHHHEE	33.59	25953088
10	Ubiquitination	LTSAYQHKLAEKLTI HHHHHHHHHHHHHEE	33.59	22817900
11	Ubiquitination	TSAYQHKLAEKLTIL HHHHHHHHHHHHEEE	7.55	21890473
14	Acetylation	YQHKLAEKLTILNDR HHHHHHHHHEEECCC	45.37	25953088
14	Ubiquitination	YQHKLAEKLTILNDR HHHHHHHHHEEECCC	45.37	29967540
30	Phosphorylation	QGVLIRMYNIKKTCS CEEEEEEEEECCCCC	12.14	30622161
33	Ubiquitination	LIRMYNIKKTCSDPK EEEEEEECCCCCCCC	38.09	-
40	Ubiquitination	KKTCSDPKSKPPFLL CCCCCCCCCCCCCCH	75.90	29967540
42	Ubiquitination	TCSDPKSKPPFLLEK CCCCCCCCCCCCHHC	63.94	29967540
49	Ubiquitination	KPPFLLEKSMEPSLK CCCCCHHCCCCCCHH	55.88	29967540
56	Ubiquitination	KSMEPSLKYINKKFP CCCCCCHHHHCHHCC	48.71	22817900
56	Acetylation	KSMEPSLKYINKKFP CCCCCCHHHHCHHCC	48.71	2402895
60	Ubiquitination	PSLKYINKKFPNIDV CCHHHHCHHCCCCCC	46.35	21906983
60	Ubiquitination	PSLKYINKKFPNIDV CCHHHHCHHCCCCCC	46.35	21890473
61	Ubiquitination	SLKYINKKFPNIDVR CHHHHCHHCCCCCCC	62.66	22817900
61	Ubiquitination	SLKYINKKFPNIDVR CHHHHCHHCCCCCCC	62.66	21890473
81	Ubiquitination	LGPVHREKAEIIRFL CCCCHHHHHHHHHHH	51.80	-
81	Acetylation	LGPVHREKAEIIRFL CCCCHHHHHHHHHHH	51.80	25953088
139	Ubiquitination	LDLIVTYTSVILLLS HHHHHHHHHHHHHHH	13.73	29967540
188	Ubiquitination	LEYDHPLKKLTEEFG HHCCCHHHHHHHHHC	50.62	-
188	Acetylation	LEYDHPLKKLTEEFG HHCCCHHHHHHHHHC	50.62	25953088
189	Ubiquitination	EYDHPLKKLTEEFGP HCCCHHHHHHHHHCC	69.22	29967540
263	Ubiquitination	MERWIIIGFLLCHGC HHHHHHHHHHHHHCC	9.20	29967540
273	Ubiquitination	LCHGCLNSNSQCQKL HHHCCCCCCHHHHHH	25.55	24816145
276	Ubiquitination	GCLNSNSQCQKLWKL CCCCCCHHHHHHHHH	37.60	29967540
299	Ubiquitination	TLIREDVLQVHKVTE EEEHHHHHHHCHHHH	7.33	29967540
311	Phosphorylation	VTEDLFSSLKGYGKR HHHHHHHHHCCCCCC	27.11	23911959
313	Acetylation	EDLFSSLKGYGKRVA HHHHHHHCCCCCCHH	52.62	25953088
313	Ubiquitination	EDLFSSLKGYGKRVA HHHHHHHCCCCCCHH	52.62	29967540
315	Phosphorylation	LFSSLKGYGKRVADI HHHHHCCCCCCHHHH	20.20	23911959
323	Ubiquitination	GKRVADIKESKEHVI CCCHHHHHHHHCCEE	57.38	24816145
323	Acetylation	GKRVADIKESKEHVI CCCHHHHHHHHCCEE	57.38	25953088
326	Ubiquitination	VADIKESKEHVIANS HHHHHHHHCCEECCC	53.59	29967540
349	Ubiquitination	QFLRMAVKELETVLA HHHHHHHHHHHHHHC	47.22	29967540
467	Phosphorylation	SSFVSILSSLNLKQV HHHHHHHHHCCCEEC	30.98	27251275
500	Ubiquitination	QAYTSVAKAPLHLHE HHHHHHHCCCCCCCC	48.67	-
580	Ubiquitination	AHFVHCTHEMCPEEY HHHHHHCHHCCCCCC	26.62	29967540
588	Ubiquitination	EMCPEEYPHLKNHGL HCCCCCCHHHHHCCH	29.61	29967540
600	Phosphorylation	HGLHHCNSFLEELAK CCHHHHHHHHHHHHH	36.28	30108239
610	Ubiquitination	EELAKQTSNCVLEIC HHHHHHHCCHHHHHH	26.24	24816145
624	Phosphorylation	CAEQRNLSEQLLPKH HHHHCCCCHHHCCHH	27.18	21659604
630	Ubiquitination	LSEQLLPKHCATTIS CCHHHCCHHHHHHHH	51.81	29967540
634	Phosphorylation	LLPKHCATTISKAKN HCCHHHHHHHHHHHC	30.01	28060719
635	Phosphorylation	LPKHCATTISKAKNK CCHHHHHHHHHHHCH	12.53	28060719
638	Ubiquitination	HCATTISKAKNKKTR HHHHHHHHHHCHHHH	60.57	29967540
650	Phosphorylation	KTRKQRQTPRKGEPE HHHHHCCCCCCCCCC	27.53	-
660	Ubiquitination	KGEPERDKPGAESHR CCCCCCCCCCCHHHH	52.12	24816145
665	Phosphorylation	RDKPGAESHRKNRSI CCCCCCHHHHCCHHH	28.23	29083192
671	Phosphorylation	ESHRKNRSIVTNMDK HHHHCCHHHCCCHHH	30.70	30108239
674	Phosphorylation	RKNRSIVTNMDKLHL HCCHHHCCCHHHHCC	24.13	30576142
747	Phosphorylation	LLAGVKAYIGFIQSL HHHHHHHHHHHHHHH	8.89	-
802	Phosphorylation	ESLLRQASSGTIILS HHHHHHHCCCCEEEC	22.44	22210691
803	Phosphorylation	SLLRQASSGTIILSP HHHHHHCCCCEEECH	42.86	22210691
817	Phosphorylation	PAMQAFVSLPREGEQ HHHHHHHCCCCCCCC	26.63	24719451
853	Phosphorylation	PYGMKFLSENLMWHV HHHHHHHCHHHHHHH	27.80	30377224
861	Phosphorylation	ENLMWHVTSQIVELK HHHHHHHHHHHHHHH	11.30	30377224
862	Phosphorylation	NLMWHVTSQIVELKK HHHHHHHHHHHHHHH	19.47	30377224
887	Ubiquitination	QIRSNFSKPDLMASL HHHHCCCCHHHHHHH	38.11	-
909	Phosphorylation	ENVLKRMTIIGVILS HHHHHHHHHHHHHHH	17.30	-
1035	Acetylation	NNIHCLTKAIIQVSA CCHHHHHHHHHHHHH	25.33	20167786
1079	Phosphorylation	QETDKLKTRNRESIS CCCHHHCCCCHHHHH	43.54	27174698
1084	Phosphorylation	LKTRNRESISLLMRL HCCCCHHHHHHHHHH	17.78	27174698
1086	Phosphorylation	TRNRESISLLMRLVV CCCHHHHHHHHHHHH	25.40	27174698
1096	Phosphorylation	MRLVVEESSFLTLDM HHHHHCCCCCCHHHH	16.94	27174698
1097	Phosphorylation	RLVVEESSFLTLDML HHHHCCCCCCHHHHH	27.79	27174698
1100	Phosphorylation	VEESSFLTLDMLESC HCCCCCCHHHHHHHH	20.78	27174698
1106	Phosphorylation	LTLDMLESCFPYVLL CHHHHHHHHHHHHHH	19.66	27174698
1110	Phosphorylation	MLESCFPYVLLRNAY HHHHHHHHHHHHHHH	5.40	27174698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCKPL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCKPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCKPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANXA2_HUMAN	ANXA2	physical	26344197
CYFP1_HUMAN	CYFIP1	physical	26344197
CYFP2_HUMAN	CYFIP2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.