| UniProt ID | FMNL1_HUMAN | |
|---|---|---|
| UniProt AC | O95466 | |
| Protein Name | Formin-like protein 1 | |
| Gene Name | FMNL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1100 | |
| Subcellular Localization |
Cytoplasm. Cell membrane Lipid-anchor . Cytoplasmic vesicle, phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).. Isoform 3: Cytoplasm, cell cortex. Cell p |
|
| Protein Description | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.. | |
| Protein Sequence | MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTARTGKRTSRLLCEASLGEEMPL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | N-myristoyl glycine | ------MGNAAGSAE ------CCCCCCCCC | - | ||
| 2 | Myristoylation | ------MGNAAGSAE ------CCCCCCCCC | 19815554 | ||
| 7 | Phosphorylation | -MGNAAGSAEQPAGP -CCCCCCCCCCCCCC | 19690332 | ||
| 29 | Sulfoxidation | PAPPKQPMPAAGELE CCCCCCCCCCCHHHH | 21406390 | ||
| 52 | Ubiquitination | CMNLPPDKVQLLSQY HHCCCHHHHHHHHHC | 29967540 | ||
| 55 | Ubiquitination | LPPDKVQLLSQYDNE CCHHHHHHHHHCCCH | 22817900 | ||
| 57 | Ubiquitination | PDKVQLLSQYDNEKK HHHHHHHHHCCCHHC | 22817900 | ||
| 59 | Phosphorylation | KVQLLSQYDNEKKWE HHHHHHHCCCHHCEE | 28796482 | ||
| 63 | Ubiquitination | LSQYDNEKKWELICD HHHCCCHHCEEEEEC | 29967540 | ||
| 64 | Ubiquitination | SQYDNEKKWELICDQ HHCCCHHCEEEEECH | 29967540 | ||
| 80 | Ubiquitination | RFQVKNPPAAYIQKL HCCCCCCCHHHHHHH | 21890473 | ||
| 86 | Ubiquitination | PPAAYIQKLKSYVDT CCHHHHHHHHHHHHC | 22817900 | ||
| 88 | Methylation | AAYIQKLKSYVDTGG HHHHHHHHHHHHCCC | - | ||
| 88 | Ubiquitination | AAYIQKLKSYVDTGG HHHHHHHHHHHHCCC | 21906983 | ||
| 88 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 88 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 89 | Phosphorylation | AYIQKLKSYVDTGGV HHHHHHHHHHHCCCC | 24247654 | ||
| 90 | Nitration | YIQKLKSYVDTGGVS HHHHHHHHHHCCCCC | - | ||
| 90 | Phosphorylation | YIQKLKSYVDTGGVS HHHHHHHHHHCCCCC | 29759185 | ||
| 99 | Ubiquitination | DTGGVSRKVAADWMS HCCCCCHHHHHHHHH | 29967540 | ||
| 99 (in isoform 3) | Ubiquitination | - | - | ||
| 111 | Ubiquitination | WMSNLGFKRRVQEST HHHHCCHHHHHHHHH | 21890473 | ||
| 111 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 126 | Phosphorylation | QVLRELETSLRTNHI HHHHHHHHHHHHCCH | 22468782 | ||
| 127 | Phosphorylation | VLRELETSLRTNHIG HHHHHHHHHHHCCHH | 22468782 | ||
| 130 | Phosphorylation | ELETSLRTNHIGWVQ HHHHHHHHCCHHHHH | 22468782 | ||
| 184 | Phosphorylation | KNKPLEQSVEDLSKG CCCCHHHHHHHHHCC | 22167270 | ||
| 189 | Phosphorylation | EQSVEDLSKGPPSSV HHHHHHHHCCCCCCC | 30266825 | ||
| 194 | Phosphorylation | DLSKGPPSSVPKSRH HHHCCCCCCCCCCCC | 26074081 | ||
| 195 | Phosphorylation | LSKGPPSSVPKSRHL HHCCCCCCCCCCCCE | 26074081 | ||
| 198 | Ubiquitination | GPPSSVPKSRHLTIK CCCCCCCCCCCEEEE | 29967540 | ||
| 203 | Phosphorylation | VPKSRHLTIKLTPAH CCCCCCEEEECCHHH | 23403867 | ||
| 205 | Ubiquitination | KSRHLTIKLTPAHSR CCCCEEEECCHHHHH | 29967540 | ||
| 207 | Phosphorylation | RHLTIKLTPAHSRKA CCEEEECCHHHHHHH | 30266825 | ||
| 211 | Phosphorylation | IKLTPAHSRKALRNS EECCHHHHHHHHHCC | 30266825 | ||
| 218 | Phosphorylation | SRKALRNSRIVSQKD HHHHHHCCCCCCCCC | 29514088 | ||
| 413 | Ubiquitination | EQVALLTERLRDAEN HHHHHHHHHHHHHCH | 24816145 | ||
| 428 | Ubiquitination | ESMAKIAELEKQLSQ HHHHHHHHHHHHHHH | 24816145 | ||
| 431 | Ubiquitination | AKIAELEKQLSQARK HHHHHHHHHHHHHHH | 29967540 | ||
| 434 | Ubiquitination | AELEKQLSQARKELE HHHHHHHHHHHHHHH | 24816145 | ||
| 438 | Ubiquitination | KQLSQARKELETLRE HHHHHHHHHHHHHHH | 24816145 | ||
| 444 | Ubiquitination | RKELETLRERFSEST HHHHHHHHHHHHHHC | 24816145 | ||
| 479 | Ubiquitination | RPSALELKVEELEEK CCCHHEEEHHHHHHC | 29967540 | ||
| 486 | Ubiquitination | KVEELEEKGLIRILR EHHHHHHCCCEEECC | 29967540 | ||
| 597 | Phosphorylation | PPPPPPGTDGPVPPP CCCCCCCCCCCCCCC | 21082442 | ||
| 609 | Ubiquitination | PPPPPPPPPPPGGPP CCCCCCCCCCCCCCC | 24816145 | ||
| 624 | Phosphorylation | DALGRRDSELGPGVK CCCCCCCCCCCCCCC | 29255136 | ||
| 624 | Ubiquitination | DALGRRDSELGPGVK CCCCCCCCCCCCCCC | 24816145 | ||
| 630 | Ubiquitination | DSELGPGVKAKKPIQ CCCCCCCCCCCCCCC | 24816145 | ||
| 631 | Acetylation | SELGPGVKAKKPIQT CCCCCCCCCCCCCCC | 25953088 | ||
| 631 | Ubiquitination | SELGPGVKAKKPIQT CCCCCCCCCCCCCCC | - | ||
| 631 (in isoform 3) | Ubiquitination | - | - | ||
| 634 | Ubiquitination | GPGVKAKKPIQTKFR CCCCCCCCCCCCCCC | 24816145 | ||
| 640 | Ubiquitination | KKPIQTKFRMPLLNW CCCCCCCCCCCCCCH | 24816145 | ||
| 651 | Ubiquitination | LLNWVALKPSQITGT CCCHHEECHHHCCCE | - | ||
| 671 | Ubiquitination | NDEKVLQELDMSDFE CCHHHHHHCCHHHHH | 22817900 | ||
| 673 | Ubiquitination | EKVLQELDMSDFEEQ HHHHHHCCHHHHHHH | 22817900 | ||
| 675 | Phosphorylation | VLQELDMSDFEEQFK HHHHCCHHHHHHHHC | 21712546 | ||
| 677 | Ubiquitination | QELDMSDFEEQFKTK HHCCHHHHHHHHCHH | 22817900 | ||
| 681 | Ubiquitination | MSDFEEQFKTKSQGP HHHHHHHHCHHCCCC | 22817900 | ||
| 682 | Ubiquitination | SDFEEQFKTKSQGPS HHHHHHHCHHCCCCC | 29967540 | ||
| 683 | Phosphorylation | DFEEQFKTKSQGPSL HHHHHHCHHCCCCCC | 27690223 | ||
| 684 | Ubiquitination | FEEQFKTKSQGPSLD HHHHHCHHCCCCCCC | 29967540 | ||
| 685 | Phosphorylation | EEQFKTKSQGPSLDL HHHHCHHCCCCCCCH | 30266825 | ||
| 686 | Ubiquitination | EQFKTKSQGPSLDLS HHHCHHCCCCCCCHH | 22817900 | ||
| 688 | Ubiquitination | FKTKSQGPSLDLSAL HCHHCCCCCCCHHHH | 22817900 | ||
| 689 | Phosphorylation | KTKSQGPSLDLSALK CHHCCCCCCCHHHHH | 30266825 | ||
| 692 | Ubiquitination | SQGPSLDLSALKSKA CCCCCCCHHHHHHHH | 22817900 | ||
| 693 | Phosphorylation | QGPSLDLSALKSKAA CCCCCCHHHHHHHHH | 30266825 | ||
| 694 | Ubiquitination | GPSLDLSALKSKAAQ CCCCCHHHHHHHHHH | 22817900 | ||
| 696 | Ubiquitination | SLDLSALKSKAAQKA CCCHHHHHHHHHHHC | 21906983 | ||
| 696 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 696 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 696 (in isoform 3) | Ubiquitination | - | - | ||
| 698 | Ubiquitination | DLSALKSKAAQKAPS CHHHHHHHHHHHCCC | 22817900 | ||
| 702 | Ubiquitination | LKSKAAQKAPSKATL HHHHHHHHCCCCCHH | 22817900 | ||
| 704 | Ubiquitination | SKAAQKAPSKATLIE HHHHHHCCCCCHHHH | 22817900 | ||
| 705 | Phosphorylation | KAAQKAPSKATLIEA HHHHHCCCCCHHHHH | 29743597 | ||
| 706 | Ubiquitination | AAQKAPSKATLIEAN HHHHCCCCCHHHHHH | 21906983 | ||
| 706 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 706 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 708 | Phosphorylation | QKAPSKATLIEANRA HHCCCCCHHHHHHHH | 20068231 | ||
| 708 | Ubiquitination | QKAPSKATLIEANRA HHCCCCCHHHHHHHH | 22817900 | ||
| 712 | Ubiquitination | SKATLIEANRAKNLA CCCHHHHHHHHHHHE | 22817900 | ||
| 716 | Ubiquitination | LIEANRAKNLAITLR HHHHHHHHHHEEEEC | - | ||
| 724 | Ubiquitination | NLAITLRKGNLGAER HHEEEECCCCCCHHH | - | ||
| 760 | Phosphorylation | MRFLPTEYERSLITR HHHCCCHHHHHHHHH | - | ||
| 763 | Phosphorylation | LPTEYERSLITRFER CCCHHHHHHHHHHHH | 24719451 | ||
| 779 | Phosphorylation | QRPMEELSEEDRFML CCCHHHCCHHHHHHH | - | ||
| 789 | Phosphorylation | DRFMLCFSRIPRLPE HHHHHHHCCCCCCCC | 24719451 | ||
| 846 | Ubiquitination | EIVLAFGNYMNSSKR HHHHHHHHHHCCCCC | 22817900 | ||
| 847 | Phosphorylation | IVLAFGNYMNSSKRG HHHHHHHHHCCCCCC | 23909892 | ||
| 850 | Phosphorylation | AFGNYMNSSKRGAAY HHHHHHCCCCCCCCH | 23909892 | ||
| 851 | Phosphorylation | FGNYMNSSKRGAAYG HHHHHCCCCCCCCHH | 23909892 | ||
| 851 | Ubiquitination | FGNYMNSSKRGAAYG HHHHHCCCCCCCCHH | 22817900 | ||
| 857 | Phosphorylation | SSKRGAAYGFRLQSL CCCCCCCHHCHHHHH | - | ||
| 861 | Ubiquitination | GAAYGFRLQSLDALL CCCHHCHHHHHHHHH | 22817900 | ||
| 866 | Ubiquitination | FRLQSLDALLEMKST CHHHHHHHHHHCCCC | 22817900 | ||
| 867 | Ubiquitination | RLQSLDALLEMKSTD HHHHHHHHHHCCCCC | 22817900 | ||
| 870 | Sulfoxidation | SLDALLEMKSTDRKQ HHHHHHHCCCCCHHH | 21406390 | ||
| 871 | Ubiquitination | LDALLEMKSTDRKQT HHHHHHCCCCCHHHH | 21906983 | ||
| 871 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 871 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 872 | Ubiquitination | DALLEMKSTDRKQTL HHHHHCCCCCHHHHH | 22817900 | ||
| 876 | Ubiquitination | EMKSTDRKQTLLHYL HCCCCCHHHHHHHHH | 22817900 | ||
| 877 | Ubiquitination | MKSTDRKQTLLHYLV CCCCCHHHHHHHHHH | 22817900 | ||
| 882 | Ubiquitination | RKQTLLHYLVKVIAE HHHHHHHHHHHHHHH | 22817900 | ||
| 909 | Phosphorylation | HFLDKAGSVSLDSVL CCHHCCCCCCHHHHH | 27080861 | ||
| 911 | Phosphorylation | LDKAGSVSLDSVLAD HHCCCCCCHHHHHHH | 27067055 | ||
| 914 | Phosphorylation | AGSVSLDSVLADVRS CCCCCHHHHHHHHHH | 27080861 | ||
| 918 | Ubiquitination | SLDSVLADVRSLQRG CHHHHHHHHHHHHHH | 22817900 | ||
| 921 | Phosphorylation | SVLADVRSLQRGLEL HHHHHHHHHHHHHHH | 27080861 | ||
| 933 | Ubiquitination | LELTQREFVRQDDCM HHHHHHHHHCHHHHH | 22817900 | ||
| 936 | Ubiquitination | TQREFVRQDDCMVLK HHHHHHCHHHHHHHH | 22817900 | ||
| 939 | Ubiquitination | EFVRQDDCMVLKEFL HHHCHHHHHHHHHHH | 22817900 | ||
| 943 | Ubiquitination | QDDCMVLKEFLRANS HHHHHHHHHHHHHCC | 21906983 | ||
| 943 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 943 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 943 (in isoform 3) | Ubiquitination | - | - | ||
| 949 | Ubiquitination | LKEFLRANSPTMDKL HHHHHHHCCCCHHHH | 22817900 | ||
| 950 | Phosphorylation | KEFLRANSPTMDKLL HHHHHHCCCCHHHHH | 27067055 | ||
| 951 | Ubiquitination | EFLRANSPTMDKLLA HHHHHCCCCHHHHHC | 22817900 | ||
| 957 | Ubiquitination | SPTMDKLLADSKTAQ CCCHHHHHCCCHHHH | 22817900 | ||
| 961 | Ubiquitination | DKLLADSKTAQEAFE HHHHCCCHHHHHHHH | 21906983 | ||
| 961 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 961 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 967 | Ubiquitination | SKTAQEAFESVVEYF CHHHHHHHHHHHHHH | 22817900 | ||
| 995 | Ubiquitination | SLFSRFIKAYKKAEQ HHHHHHHHHHHHHHH | - | ||
| 999 | Ubiquitination | RFIKAYKKAEQEVEQ HHHHHHHHHHHHHHH | - | ||
| 999 (in isoform 3) | Ubiquitination | - | - | ||
| 1008 (in isoform 3) | Ubiquitination | - | - | ||
| 1009 (in isoform 3) | Ubiquitination | - | - | ||
| 1019 | Ubiquitination | AAQEAGADTPGKGEP HHHHCCCCCCCCCCC | 22817900 | ||
| 1020 | Phosphorylation | AQEAGADTPGKGEPP HHHCCCCCCCCCCCC | 23401153 | ||
| 1022 | Ubiquitination | EAGADTPGKGEPPAP HCCCCCCCCCCCCCC | 22817900 | ||
| 1024 | Ubiquitination | GADTPGKGEPPAPKS CCCCCCCCCCCCCCC | 22817900 | ||
| 1027 | Ubiquitination | TPGKGEPPAPKSPPK CCCCCCCCCCCCCCC | 22817900 | ||
| 1031 | Phosphorylation | GEPPAPKSPPKARRP CCCCCCCCCCCCCCC | 22167270 | ||
| 1037 | Ubiquitination | KSPPKARRPQMDLIS CCCCCCCCCCCHHHH | 22817900 | ||
| 1040 | Sulfoxidation | PKARRPQMDLISELK CCCCCCCCHHHHHHH | 21406390 | ||
| 1042 | Ubiquitination | ARRPQMDLISELKRR CCCCCCHHHHHHHHH | 22817900 | ||
| 1043 | Ubiquitination | RRPQMDLISELKRRQ CCCCCHHHHHHHHHH | 22817900 | ||
| 1044 | Phosphorylation | RPQMDLISELKRRQQ CCCCHHHHHHHHHHC | 25159151 | ||
| 1047 | Ubiquitination | MDLISELKRRQQKEP CHHHHHHHHHHCCCC | 22817900 | ||
| 1047 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 1047 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 1048 | Ubiquitination | DLISELKRRQQKEPL HHHHHHHHHHCCCCC | 22817900 | ||
| 1052 | Ubiquitination | ELKRRQQKEPLIYES HHHHHHCCCCCEEEC | 22817900 | ||
| 1053 | Ubiquitination | LKRRQQKEPLIYESD HHHHHCCCCCEEECC | 22817900 | ||
| 1057 | Phosphorylation | QQKEPLIYESDRDGA HCCCCCEEECCCCCC | - | ||
| 1058 | Ubiquitination | QKEPLIYESDRDGAI CCCCCEEECCCCCCH | 22817900 | ||
| 1059 (in isoform 2) | Phosphorylation | - | 29978859 | ||
| 1070 (in isoform 2) | Phosphorylation | - | 28122231 | ||
| 1078 | O-linked_Glycosylation | VIKTVPFTARTGKRT HECCCCCCCCCCCCH | 30379171 | ||
| 1099 (in isoform 2) | Phosphorylation | - | 28102081 | ||
| 1100 (in isoform 2) | Phosphorylation | - | 28111955 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FMNL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FMNL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FMNL1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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