CD20_HUMAN - dbPTM
CD20_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CD20_HUMAN
UniProt AC P11836
Protein Name B-lymphocyte antigen CD20
Gene Name MS4A1
Organism Homo sapiens (Human).
Sequence Length 297
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cell membrane
Lipid-anchor .
Protein Description This protein may be involved in the regulation of B-cell activation and proliferation..
Protein Sequence MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTTPRNSVN
------CCCCCCCCC		45.5730108239
3Phosphorylation-----MTTPRNSVNG
-----CCCCCCCCCC		20.9630108239
7Phosphorylation-MTTPRNSVNGTFPA
-CCCCCCCCCCCCCC		20.4526657352
11PhosphorylationPRNSVNGTFPAEPMK
CCCCCCCCCCCCCCC		22.6530108239
25PhosphorylationKGPIAMQSGPKPLFR
CCCCCCCCCCHHHHH		43.9330108239
35PhosphorylationKPLFRRMSSLVGPTQ
HHHHHHHHHHHCCCH		20.7828674151
36PhosphorylationPLFRRMSSLVGPTQS
HHHHHHHHHHCCCHH		20.1028674151
41PhosphorylationMSSLVGPTQSFFMRE
HHHHHCCCHHHHCCC		30.8026074081
43PhosphorylationSLVGPTQSFFMRESK
HHHCCCHHHHCCCCC		23.9526074081
111S-palmitoylationTEKNSRKCLVKGKMI
CCCCCCCHHHHHHHH		5.2629097667
121PhosphorylationKGKMIMNSLSLFAAI
HHHHHHHHHHHHHHH		11.27-
220S-palmitoylationENEWKRTCSRPKSNI
HCCHHHHCCCCCCCE		3.6429097667
225PhosphorylationRTCSRPKSNIVLLSA
HHCCCCCCCEEEEEH		34.1830108239
231PhosphorylationKSNIVLLSAEEKKEQ
CCCEEEEEHHHHHHH		29.4930108239
235UbiquitinationVLLSAEEKKEQTIEI
EEEEHHHHHHHCEEE		53.79-
236UbiquitinationLLSAEEKKEQTIEIK
EEEHHHHHHHCEEEE		59.33-
239PhosphorylationAEEKKEQTIEIKEEV
HHHHHHHCEEEEHHH		22.9730108239
243UbiquitinationKEQTIEIKEEVVGLT
HHHCEEEEHHHHCCC		34.72-
250PhosphorylationKEEVVGLTETSSQPK
EHHHHCCCCCCCCCC		31.1530108239
252PhosphorylationEVVGLTETSSQPKNE
HHHCCCCCCCCCCCH		28.5730108239
253PhosphorylationVVGLTETSSQPKNEE
HHCCCCCCCCCCCHH		22.2726657352
254PhosphorylationVGLTETSSQPKNEED
HCCCCCCCCCCCHHC		58.9030108239
275PhosphorylationQEEEEEETETNFPEP
CHHHHHHCCCCCCCC		51.9228348404
277PhosphorylationEEEEETETNFPEPPQ
HHHHHCCCCCCCCCC		49.9728348404
288PhosphorylationEPPQDQESSPIENDS
CCCCCCCCCCCCCCC		35.4628348404
289PhosphorylationPPQDQESSPIENDSS
CCCCCCCCCCCCCCC		29.197678037
295PhosphorylationSSPIENDSSP-----
CCCCCCCCCC-----		56.9728348404
296PhosphorylationSPIENDSSP------
CCCCCCCCC------		37.1828348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
231SPhosphorylationKinaseCK2-FAMILY-GPS
231SPhosphorylationKinaseCK2_GROUP-PhosphoELM
250TPhosphorylationKinaseCK2-FAMILY-GPS
250TPhosphorylationKinaseCK2_GROUP-PhosphoELM
289SPhosphorylationKinaseCK2-FAMILY-GPS
289SPhosphorylationKinaseCK2_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CD20_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CD20_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LCK_HUMANLCKphysical
7545683
FYN_HUMANFYNphysical
7545683
PRDM1_HUMANPRDM1physical
22167754
KASH5_HUMANCCDC155physical
25416956
Drug and Disease Associations
Kegg Disease
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
H00011 Lymphoplasmacytic lymphoma
H00088 Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell cos
OMIM Disease
613495Immunodeficiency, common variable, 5 (CVID5)
Kegg Drug
D02994 Rituximab (genetical recombination) (JAN); Rituximab (USAN/INN); Rituxan (TN)
D04489 Ibritumomab tiuxetan (genetical recombination) (JAN); Ibritumomab tiuxetan (USAN/INN); Zevalin (TN)
D05218 Ocrelizumab (genetical recombination) (JAN); Ocrelizumab (USAN)
D08621 Tositumomab (INN)
D08622 Tositumomab 131 iodine; Tositumomab iodine 131I; Bexxar (TN)
D09031 Veltuzumab (USAN)
D09314 Ofatumumab (genetical recombination) (JAN); Ofatumumab (USAN/INN); Arzerra (TN)
D09321 Obinutuzumab (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CD20_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-36, AND MASSSPECTROMETRY.

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