dbPTM

FLI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLI1_HUMAN
UniProt AC	Q01543
Protein Name	Friend leukemia integration 1 transcription factor
Gene Name	FLI1
Organism	Homo sapiens (Human).
Sequence Length	452
Subcellular Localization	Nucleus .
Protein Description	Sequence-specific transcriptional activator. [PubMed: 24100448]
Protein Sequence	MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATTLYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNKSPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 3)	Phosphorylation	-	36.45	27642862
9 (in isoform 3)	Phosphorylation	-	4.13	27642862
10	Phosphorylation	GTIKEALSVVSDDQS CCHHHHHHHHCCCHH	27.76	-
11 (in isoform 4)	Phosphorylation	-	5.06	25690035
12 (in isoform 4)	Phosphorylation	-	4.70	25690035
13	Phosphorylation	KEALSVVSDDQSLFD HHHHHHHCCCHHHHH	33.06	24247654
17	Phosphorylation	SVVSDDQSLFDSAYG HHHCCCHHHHHHHHH	37.69	29978859
21	Phosphorylation	DDQSLFDSAYGAAAH CCHHHHHHHHHHHHC	18.96	29978859
23	Phosphorylation	QSLFDSAYGAAAHLP HHHHHHHHHHHHCCC	15.96	29978859
35	Phosphorylation	HLPKADMTASGSPDY CCCHHHCCCCCCCCC	20.44	29255136
37	Phosphorylation	PKADMTASGSPDYGQ CHHHCCCCCCCCCCC	30.55	23401153
39	Phosphorylation	ADMTASGSPDYGQPH HHCCCCCCCCCCCCC	16.47	23401153
42	Phosphorylation	TASGSPDYGQPHKIN CCCCCCCCCCCCCCC	22.50	28787133
47	Ubiquitination	PDYGQPHKINPLPPQ CCCCCCCCCCCCCCC	51.35	-
67	Sumoylation	QPVRVNVKREYDHMN CCCEEEECHHCCCCC	34.02	-
67	Sumoylation	QPVRVNVKREYDHMN CCCEEEECHHCCCCC	34.02	-
70	Phosphorylation	RVNVKREYDHMNGSR EEEECHHCCCCCCCC	18.38	23403867
76	Phosphorylation	EYDHMNGSRESPVDC HCCCCCCCCCCCCCC	28.06	23401153
79	Phosphorylation	HMNGSRESPVDCSVS CCCCCCCCCCCCCHH	29.16	23401153
84	Phosphorylation	RESPVDCSVSKCSKL CCCCCCCCHHHCCCC	25.59	23403867
84	O-linked_Glycosylation	RESPVDCSVSKCSKL CCCCCCCCHHHCCCC	25.59	27655845
86	Phosphorylation	SPVDCSVSKCSKLVG CCCCCCHHHCCCCCC	16.20	23403867
86	O-linked_Glycosylation	SPVDCSVSKCSKLVG CCCCCCHHHCCCCCC	16.20	27655845
87	Acetylation	PVDCSVSKCSKLVGG CCCCCHHHCCCCCCC	40.13	25953088
87	Ubiquitination	PVDCSVSKCSKLVGG CCCCCHHHCCCCCCC	40.13	-
89	Phosphorylation	DCSVSKCSKLVGGGE CCCHHHCCCCCCCCC	32.53	26074081
90	Acetylation	CSVSKCSKLVGGGES CCHHHCCCCCCCCCC	57.57	25953088
106	Ubiquitination	PMNYNSYMDEKNGPP CCCHHHHCCCCCCCC	5.57	21890473
106 (in isoform 2)	Ubiquitination	-	5.57	21890473
117	Sulfoxidation	NGPPPPNMTTNERRV CCCCCCCCCCCCCEE	6.36	21406390
139	Ubiquitination	LWTQEHVRQWLEWAI CCCHHHHHHHHHHHH	24.70	21890473
172	Ubiquitination	KELCKMNKEDFLRAT HHHHHCCHHHHHHHH	55.98	21890473
172 (in isoform 1)	Ubiquitination	-	55.98	21890473
179	Phosphorylation	KEDFLRATTLYNTEV HHHHHHHHHHHCHHH	15.76	19690332
182	Phosphorylation	FLRATTLYNTEVLLS HHHHHHHHCHHHHHH	20.25	19690332
192	Phosphorylation	EVLLSHLSYLRESSL HHHHHHHHHHHHHCC	19.39	19690332
215	Phosphorylation	TDQSSRLSVKEDPSY CCCCCCCCCCCCCCH	29.99	23401153
217	Ubiquitination	QSSRLSVKEDPSYDS CCCCCCCCCCCCHHH	53.69	-
221	Phosphorylation	LSVKEDPSYDSVRRG CCCCCCCCHHHHHCC	54.62	28796482
221	O-linked_Glycosylation	LSVKEDPSYDSVRRG CCCCCCCCHHHHHCC	54.62	27655845
222	Phosphorylation	SVKEDPSYDSVRRGA CCCCCCCHHHHHCCC	20.02	28796482
224	Phosphorylation	KEDPSYDSVRRGAWG CCCCCHHHHHCCCCC	14.86	28796482
224	O-linked_Glycosylation	KEDPSYDSVRRGAWG CCCCCHHHHHCCCCC	14.86	27655845
236	Phosphorylation	AWGNNMNSGLNKSPP CCCCCCCCCCCCCCC	33.61	23927012
240	Acetylation	NMNSGLNKSPPLGGA CCCCCCCCCCCCCCC	70.18	22973553
240	Ubiquitination	NMNSGLNKSPPLGGA CCCCCCCCCCCCCCC	70.18	-
241	Phosphorylation	MNSGLNKSPPLGGAQ CCCCCCCCCCCCCCC	30.58	23401153
249	Phosphorylation	PPLGGAQTISKNTEQ CCCCCCCCCCCCCCC	27.04	23403867
251	Phosphorylation	LGGAQTISKNTEQRP CCCCCCCCCCCCCCC	24.20	23403867
252	Acetylation	GGAQTISKNTEQRPQ CCCCCCCCCCCCCCC	65.13	22973553
254	Phosphorylation	AQTISKNTEQRPQPD CCCCCCCCCCCCCCC	36.91	26074081
263	Phosphorylation	QRPQPDPYQILGPTS CCCCCCCCCCCCCCC	18.63	28796482
312	Phosphorylation	TNGEFKMTDPDEVAR CCCEEEECCHHHHHH	44.99	22591006
325	Ubiquitination	ARRWGERKSKPNMNY HHHHHHCCCCCCCCH	59.54	-
332	Phosphorylation	KSKPNMNYDKLSRAL CCCCCCCHHHHHHHH	12.04	-
334	Ubiquitination	KPNMNYDKLSRALRY CCCCCHHHHHHHHHH	37.69	-
334	Acetylation	KPNMNYDKLSRALRY CCCCCHHHHHHHHHH	37.69	-
345	Acetylation	ALRYYYDKNIMTKVH HHHHHHHCCCEEEEC	32.05	-
350	Acetylation	YDKNIMTKVHGKRYA HHCCCEEEECCEEEE	18.17	-
350	Ubiquitination	YDKNIMTKVHGKRYA HHCCCEEEECCEEEE	18.17	-
380	Acetylation	PTESSMYKYPSDISY CCCCCCCCCCCCCCC	41.88	17884818
380	Ubiquitination	PTESSMYKYPSDISY CCCCCCCCCCCCCCC	41.88	-
383	Phosphorylation	SSMYKYPSDISYMPS CCCCCCCCCCCCCCC	44.48	27080861
386	Phosphorylation	YKYPSDISYMPSYHA CCCCCCCCCCCCCCC	21.99	27080861
387	Phosphorylation	KYPSDISYMPSYHAH CCCCCCCCCCCCCCC	17.24	27080861
390	Phosphorylation	SDISYMPSYHAHQQK CCCCCCCCCCCCCCC	17.02	27080861
391	Phosphorylation	DISYMPSYHAHQQKV CCCCCCCCCCCCCCC	9.35	27080861
397	Acetylation	SYHAHQQKVNFVPPH CCCCCCCCCCCCCCC	32.35	22973553
406	O-linked_Glycosylation	NFVPPHPSSMPVTSS CCCCCCCCCCCCCCC	35.91	27655845
407	O-linked_Glycosylation	FVPPHPSSMPVTSSS CCCCCCCCCCCCCCH	31.40	27655845
411	O-linked_Glycosylation	HPSSMPVTSSSFFGA CCCCCCCCCCHHCCC	19.61	27655845
412	O-linked_Glycosylation	PSSMPVTSSSFFGAA CCCCCCCCCHHCCCC	24.99	27655845
413	O-linked_Glycosylation	SSMPVTSSSFFGAAS CCCCCCCCHHCCCCC	23.07	27655845
414	O-linked_Glycosylation	SMPVTSSSFFGAASQ CCCCCCCHHCCCCCC	25.10	27655845
420	O-linked_Glycosylation	SSFFGAASQYWTSPT CHHCCCCCCCEECCC	24.22	27655845
424	O-linked_Glycosylation	GAASQYWTSPTGGIY CCCCCCEECCCCCCC	21.64	27655845
425	O-linked_Glycosylation	AASQYWTSPTGGIYP CCCCCEECCCCCCCC	13.30	27655845
427	O-linked_Glycosylation	SQYWTSPTGGIYPNP CCCEECCCCCCCCCC	48.05	27655845
438	Methylation	YPNPNVPRHPNTHVP CCCCCCCCCCCCCCC	54.32	-
450	Phosphorylation	HVPSHLGSYY----- CCCCCCCCCC-----	27.84	-
451	Phosphorylation	VPSHLGSYY------ CCCCCCCCC------	16.05	-
452	Phosphorylation	PSHLGSYY------- CCCCCCCC-------	17.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
312	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FLI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GATA1_HUMAN	GATA1	physical	12724402
SRF_HUMAN	SRF	physical	10606656
ETV6_HUMAN	ETV6	physical	9651344
GATA1_HUMAN	GATA1	physical	12556498
SMAD3_HUMAN	SMAD3	physical	20211142
PIAS2_HUMAN	PIAS2	physical	16148010
UBC9_HUMAN	UBE2I	physical	16148010
SIAH1_HUMAN	SIAH1	physical	25416956
SOX30_HUMAN	SOX30	physical	25416956
KAT2B_HUMAN	KAT2B	physical	17884818
KAT2B_HUMAN	KAT2B	physical	19158279
KPCD_HUMAN	PRKCD	physical	19158279

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612219	Ewing sarcoma (ES)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLI1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; SER-86 AND SER-89,AND MASS SPECTROMETRY.	17287340 [Abstract]