C19L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C19L1_HUMAN
• UniProt AC: Q69YN2
• Protein Name: CWF19-like protein 1
• Gene Name: CWF19L1
• Organism: Homo sapiens (Human).
• Sequence Length: 538
• Protein Sequence: MAQKPLRLLACGDVEGKFDILFNRVQAIQKKSGNFDLLLCVGNFFGSTQDAEWEEYKTGIKKAPIQTYVLGANNQETVKYFQDADGCELAENITYLGRKGIFTGSSGLQIVYLSGTESLNEPVPGYSFSPKDVSSLRMMLCTTSQFKGVDILLTSPWPKCVGNFGNSSGEVDTKKCGSALVSSLATGLKPRYHFAALEKTYYERLPYRNHIILQENAQHATRFIALANVGNPEKKKYLYAFSIVPMKLMDAAELVKQPPDVTENPYRKSGQEASIGKQILAPVEESACQFFFDLNEKQGRKRSSTGRDSKSSPHPKQPRKPPQPPGPCWFCLASPEVEKHLVVNIGTHCYLALAKGGLSDDHVLILPIGHYQSVVELSAEVVEEVEKYKATLRRFFKSRGKWCVVFERNYKSHHLQLQVIPVPISCSTTDDIKDAFITQAQEQQIELLEIPEHSDIKQIAQPGAAYFYVELDTGEKLFHRIKKNFPLQFGREVLASEAILNVPDKSDWRQCQISKEDEETLARRFRKDFEPYDFTLDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MAQKPLRLLAC ----CCCCCEEEEEE	36.16	-
7 (in isoform 3)	Phosphorylation	-	35.86	25159151
30	Acetylation	NRVQAIQKKSGNFDL HHHHHHHHHCCCCEE	42.67	25953088
62	Ubiquitination	EYKTGIKKAPIQTYV HHHCCCCCCCEEEEE	58.43	-
129	Phosphorylation	PVPGYSFSPKDVSSL CCCCCCCCHHHHHHH	25.71	24719451
134	Phosphorylation	SFSPKDVSSLRMMLC CCCHHHHHHHHHHHH	33.51	24719451
135	Phosphorylation	FSPKDVSSLRMMLCT CCHHHHHHHHHHHHC	21.60	24719451
142	Phosphorylation	SLRMMLCTTSQFKGV HHHHHHHCCCCCCCC	26.06	23186163
143	Phosphorylation	LRMMLCTTSQFKGVD HHHHHHCCCCCCCCE	21.38	23312004
144	Phosphorylation	RMMLCTTSQFKGVDI HHHHHCCCCCCCCEE	18.57	25159151
159	Ubiquitination	LLTSPWPKCVGNFGN EEECCCCCCCCCCCC	37.37	-
174	Acetylation	SSGEVDTKKCGSALV CCCCCCHHHHHHHHH	41.42	23749302
174	Ubiquitination	SSGEVDTKKCGSALV CCCCCCHHHHHHHHH	41.42	-
175	Acetylation	SGEVDTKKCGSALVS CCCCCHHHHHHHHHH	46.01	24468149
175	Ubiquitination	SGEVDTKKCGSALVS CCCCCHHHHHHHHHH	46.01	-
187 (in isoform 2)	Ubiquitination	-	26.54	21890473
189	Ubiquitination	SSLATGLKPRYHFAA HHHHCCCCCCEEEHH	28.88	-
199	Ubiquitination	YHFAALEKTYYERLP EEEHHHCCHHHHHCC	42.55	-
209 (in isoform 2)	Ubiquitination	-	25.51	21890473
234	Acetylation	ANVGNPEKKKYLYAF EECCCHHHCCEEEEE	56.68	25953088
234	Malonylation	ANVGNPEKKKYLYAF EECCCHHHCCEEEEE	56.68	26320211
237	Phosphorylation	GNPEKKKYLYAFSIV CCHHHCCEEEEEEEE	17.52	20860994
239	Phosphorylation	PEKKKYLYAFSIVPM HHHCCEEEEEEEEEC	11.51	-
242	Phosphorylation	KKYLYAFSIVPMKLM CCEEEEEEEEECHHH	17.95	20860994
268	Ubiquitination	VTENPYRKSGQEASI CCCCCCCCCCCCCCC	53.76	-
297	Ubiquitination	FFFDLNEKQGRKRSS HHEECCCCCCCCCCC	57.91	-
312	Phosphorylation	TGRDSKSSPHPKQPR CCCCCCCCCCCCCCC	30.85	24719451
320	Ubiquitination	PHPKQPRKPPQPPGP CCCCCCCCCCCCCCC	68.67	-
346 (in isoform 3)	Ubiquitination	-	12.28	21890473
368 (in isoform 3)	Ubiquitination	-	4.81	21890473
388	Phosphorylation	VVEEVEKYKATLRRF HHHHHHHHHHHHHHH	7.73	22817900
401	Acetylation	RFFKSRGKWCVVFER HHHHHCCCEEEEEEC	35.99	25953088
433	Ubiquitination	CSTTDDIKDAFITQA CCCCHHHHHHHHHHH	50.42	-
483 (in isoform 1)	Ubiquitination	-	62.54	21890473
483	Ubiquitination	KLFHRIKKNFPLQFG HHHHHHHHCCCCCCC	62.54	21890473
505 (in isoform 1)	Ubiquitination	-	44.22	21890473
505	Ubiquitination	AILNVPDKSDWRQCQ HHHCCCCHHHHCCCC	44.22	2190698
515	Ubiquitination	WRQCQISKEDEETLA HCCCCCCHHHHHHHH	71.46	-
515	Acetylation	WRQCQISKEDEETLA HCCCCCCHHHHHHHH	71.46	26051181
527	Ubiquitination	TLARRFRKDFEPYDF HHHHHHHCCCCCCCC	65.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C19L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C19L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C19L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM1L1_HUMAN	TOM1L1	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616127: Spinocerebellar ataxia, autosomal recessive, 17 (SCAR17)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.