TMM25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM25_HUMAN
• UniProt AC: Q86YD3
• Protein Name: Transmembrane protein 25
• Gene Name: TMEM25
• Organism: Homo sapiens (Human).
• Sequence Length: 366
• Subcellular Localization: Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 4: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Secreted .; Isoform 3: Secreted .
• Protein Sequence: MALPPGPAALRHTLLLLPALLSSGWGELEPQIDGQTWAERALRENERHAFTCRVAGGPGTPRLAWYLDGQLQEASTSRLLSVGGEAFSGGTSTFTVTAHRAQHELNCSLQDPRSGRSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTSASLPAPGLLATRVEVPLLGIVVAAGLALGTLVGFSTLVACLVCRKEKKTKGPSRHPSLISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDSRAVKPADRQMAQNNSRPELLDPEPGGLLTSQGFIRLPVLGYIYRVSSVSSDEIWL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	N-linked_Glycosylation	HRAQHELNCSLQDPR CHHHHHHCCCCCCCC	15.45	UniProtKB CARBOHYD
162	N-linked_Glycosylation	VRANPPANVTWIDQD HHCCCCCCEEEECCC	37.21	UniProtKB CARBOHYD
175	N-linked_Glycosylation	QDGPVTVNTSDFLVL CCCCEEEECCCEEEE	25.21	UniProtKB CARBOHYD
192	N-linked_Glycosylation	QNYPWLTNHTVQLQL CCCCCCCCHHHHHHH	27.02	UniProtKB CARBOHYD
205	N-linked_Glycosylation	QLRSLAHNLSVVATN HHHHHHHCCEEEEEC	28.53	UniProtKB CARBOHYD
271	Phosphorylation	EKKTKGPSRHPSLIS CCCCCCCCCCCHHCC	52.47	29449344
275	Phosphorylation	KGPSRHPSLISSDSN CCCCCCCHHCCCCCC	32.01	22985185
278	Phosphorylation	SRHPSLISSDSNNLK CCCCHHCCCCCCCCE	33.13	29514088
279	Phosphorylation	RHPSLISSDSNNLKL CCCHHCCCCCCCCEE	37.76	29514088
281	Phosphorylation	PSLISSDSNNLKLNN CHHCCCCCCCCEECC	29.57	29514088
297	Phosphorylation	RLPRENMSLPSNLQL ECCCCCCCCCCCCCC	49.03	29116813
308	Phosphorylation	NLQLNDLTPDSRAVK CCCCCCCCCCCCCCC	28.10	24076635
311	Phosphorylation	LNDLTPDSRAVKPAD CCCCCCCCCCCCHHH	24.28	29116813
315	Acetylation	TPDSRAVKPADRQMA CCCCCCCCHHHHHHH	33.24	7683155

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB8_HUMAN	TUBB8	physical	26186194
GRP78_HUMAN	HSPA5	physical	26186194
LARG2_HUMAN	GYLTL1B	physical	26186194
CA2D2_HUMAN	CACNA2D2	physical	26186194
EST3_HUMAN	CES3	physical	26186194
WDR60_HUMAN	WDR60	physical	26186194
AL1L2_HUMAN	ALDH1L2	physical	26186194
EHD1_HUMAN	EHD1	physical	26186194
T132A_HUMAN	TMEM132A	physical	26186194
PCSK6_HUMAN	PCSK6	physical	26186194
NOMO3_HUMAN	NOMO3	physical	26186194
LPCT4_HUMAN	LPCAT4	physical	26186194
ENTP6_HUMAN	ENTPD6	physical	26186194
TAZ_HUMAN	TAZ	physical	26186194
LARG1_HUMAN	LARGE	physical	26186194
ARSA_HUMAN	ARSA	physical	26186194
COEA1_HUMAN	COL14A1	physical	26186194
SYIM_HUMAN	IARS2	physical	26186194
LAMB1_HUMAN	LAMB1	physical	26186194
NAMPT_HUMAN	NAMPT	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
AMD_HUMAN	PAM	physical	26186194
RL23_HUMAN	RPL23	physical	26186194
COCH_HUMAN	COCH	physical	26186194
ERFE_HUMAN	FAM132B	physical	26186194
NGLY1_HUMAN	NGLY1	physical	26186194
NID2_HUMAN	NID2	physical	26186194
ADAM9_HUMAN	ADAM9	physical	26186194
PLXA1_HUMAN	PLXNA1	physical	26186194
PCAT2_HUMAN	LPCAT2	physical	26186194
EGFR_HUMAN	EGFR	physical	26186194
MOXD1_HUMAN	MOXD1	physical	26186194
BGLR_HUMAN	GUSB	physical	26186194
EF1A2_HUMAN	EEF1A2	physical	26186194
TECT1_HUMAN	TCTN1	physical	26186194
SPHM_HUMAN	SGSH	physical	26186194
LOXL2_HUMAN	LOXL2	physical	26186194
HTRA3_HUMAN	HTRA3	physical	26186194
SPA5L_HUMAN	SPATA5L1	physical	26186194
CHID1_HUMAN	CHID1	physical	26186194
FUT11_HUMAN	FUT11	physical	26186194
WDR34_HUMAN	WDR34	physical	26186194
TPA_HUMAN	PLAT	physical	26186194
BSCL2_HUMAN	BSCL2	physical	26186194
LAMB2_HUMAN	LAMB2	physical	26186194
HTRA1_HUMAN	HTRA1	physical	26186194
CO4A2_HUMAN	COL4A2	physical	26186194
MGT5A_HUMAN	MGAT5	physical	26186194
GDF11_HUMAN	GDF11	physical	26186194
LMLN_HUMAN	LMLN	physical	26186194
GT253_HUMAN	CERCAM	physical	26186194
ARSK_HUMAN	ARSK	physical	26186194
PEDF_HUMAN	SERPINF1	physical	26186194
COIA1_HUMAN	COL18A1	physical	26186194
DYR2_HUMAN	DHFRL1	physical	26186194
PEX6_HUMAN	PEX6	physical	26186194
SEM4F_HUMAN	SEMA4F	physical	26186194
BANP_HUMAN	BANP	physical	26186194
B3GLT_HUMAN	B3GALTL	physical	26186194
GNPTG_HUMAN	GNPTG	physical	26186194
BTD_HUMAN	BTD	physical	26186194
PGLT1_HUMAN	POGLUT1	physical	26186194
GLT12_HUMAN	GALNT12	physical	26186194
GLT18_HUMAN	GALNT18	physical	26186194
DEFM_HUMAN	PDF	physical	26186194
P3H3_HUMAN	LEPREL2	physical	26186194
LAMA5_HUMAN	LAMA5	physical	26186194
MA2A2_HUMAN	MAN2A2	physical	26186194
SP3_HUMAN	SP3	physical	26186194
FUZZY_HUMAN	FUZ	physical	26186194
TPRKB_HUMAN	TPRKB	physical	26186194
EST3_HUMAN	CES3	physical	28514442
HTRA3_HUMAN	HTRA3	physical	28514442
HTRA1_HUMAN	HTRA1	physical	28514442
PEX6_HUMAN	PEX6	physical	28514442
LARG1_HUMAN	LARGE	physical	28514442
DYR2_HUMAN	DHFRL1	physical	28514442
NID2_HUMAN	NID2	physical	28514442
FUT11_HUMAN	FUT11	physical	28514442
GLT18_HUMAN	GALNT18	physical	28514442
FUZZY_HUMAN	FUZ	physical	28514442
FIGL1_HUMAN	FIGNL1	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
AMD_HUMAN	PAM	physical	28514442
GDF11_HUMAN	GDF11	physical	28514442
LMLN_HUMAN	LMLN	physical	28514442
WDR60_HUMAN	WDR60	physical	28514442
GT253_HUMAN	CERCAM	physical	28514442
BSCL2_HUMAN	BSCL2	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
NAMPT_HUMAN	NAMPT	physical	28514442
LAMB2_HUMAN	LAMB2	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
TECT1_HUMAN	TCTN1	physical	28514442
BANP_HUMAN	BANP	physical	28514442
SPA5L_HUMAN	SPATA5L1	physical	28514442
LARG2_HUMAN	GYLTL1B	physical	28514442
TAZ_HUMAN	TAZ	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
ERFE_HUMAN	FAM132B	physical	28514442
ITA8_HUMAN	ITGA8	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
MA2A2_HUMAN	MAN2A2	physical	28514442
COCH_HUMAN	COCH	physical	28514442
NGLY1_HUMAN	NGLY1	physical	28514442
LAMA5_HUMAN	LAMA5	physical	28514442
SYIM_HUMAN	IARS2	physical	28514442
NDKM_HUMAN	NME4	physical	28514442
CA2D2_HUMAN	CACNA2D2	physical	28514442
PGLT1_HUMAN	POGLUT1	physical	28514442
ARSA_HUMAN	ARSA	physical	28514442
ADAM9_HUMAN	ADAM9	physical	28514442
TPA_HUMAN	PLAT	physical	28514442
P3H3_HUMAN	LEPREL2	physical	28514442
CHSTA_HUMAN	CHST10	physical	28514442
LPCT4_HUMAN	LPCAT4	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
MGT5A_HUMAN	MGAT5	physical	28514442
PLXA1_HUMAN	PLXNA1	physical	28514442
PCSK6_HUMAN	PCSK6	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.